Precocious puberty following head injury

Case report

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  • 1 Neurosurgical Service, Massachusetts General Hospital, Brigham and Women's Hospital and The Children's Hospital; Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology; and Department of Surgery, Harvard Medical School, Boston, Massachusetts
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✓ A 6-year-old girl developed secondary sexual characteristics 5 months after severe closed head injury. Endocrinological tests confirmed a pubertal sexual condition; there was also diminution of serum melatonin and disruption of the diurnal pattern. Magnetic resonance imaging demonstrated focal hypothalamic injury; this is believed to be the first time such a posttraumatic lesion has been demonstrated by imaging techniques. The pathophysiology of this condition is discussed.

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