Letter to the Editor: Anticoagulation

Rebecca Gryka Pharm.D., Ph.D. and Douglas C. Anderson Jr. Pharm.D., D.Ph., C.A.C.P.
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  • Cedarville University School of Pharmacy, Cedarville, Ohio
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  • 1

    Ageno W, , Gallus AS, , Wittkowsky A, , Crowther M, , Hylek EM, & Palareti G: Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141:2 Suppl e44Se88S, 2012

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  • 2

    Connolly SJ, , Ezekowitz MD, , Yusuf S, , Eikelboom J, , Oldgren J, & Parekh A, et al.: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:11391151, 2009. (Erratum in N Engl J Med 363:1877, 2010)

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  • 3

    Garber ST, , Sivakumar W, & Schmidt RH: Neurosurgical complications of direct thrombin inhibitors—catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran. Case report. J Neurosurg 116:10931096, 2012

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  • 4

    Granger CB, , Alexander JH, , McMurray JJV, , Lopes RD, , Hylek EM, & Hanna M, et al.: Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365:981992, 2011

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  • 5

    Huhtakangas J, , Tetri S, , Juvela S, , Saloheimo P, , Bode MK, & Hillbom M: Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study. Stroke 42:24312435, 2011

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  • 6

    Patel MR, , Mahaffey KW, , Garg J, , Pan G, , Singer DE, & Hacke W, et al.: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365:883891, 2011

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  • 7

    Sattari M, & Lowenthal DT: Novel oral anticoagulants in development: Dabigatran, Rivaroxaban, and Apixaban. Am J Ther 18:332338, 2011

  • 1

    Cano EL, & Miyares MA: Clinical challenges in a patient with dabigatran-induced fatal hemorrhage. Am J Geriatr Pharmacother 10:160163, 2012

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  • 2

    Connolly SJ, , Ezekowitz MD, , Yusuf S, , Eikelboom J, , Oldgren J, & Parekh A, et al.: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:11391151, 2009. (Erratum in N Engl J Med 363:1877, 2010)

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  • 3

    Cotton BA, , McCarthy JJ, & Holcomb JB: Acutely injured patients on dabigatran. N Engl J Med 365:20392040, 2011. (Letter)

  • 4

    Harper P, , Young L, & Merriman E: Bleeding risk with dabigatran in the frail elderly. N Engl J Med 366:864866, 2012. (Letter)

  • 5

    Stangier J, , Rathgen K, , Stähle H, & Mazur D: Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 49:259268, 2010

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  • 6

    US Food Drug Administration: FDA Drug Safety Communication: Safety review of post-market reports of serious bleeding events with the anticoagulant Pradaxa (dabigatran etexilate mesylate) US Department of Health and Human Services, 2011. (http://www.fda.gov/drugs/drugsafety/ucm282724.htm) [Accessed October 30, 2012]

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