Journal of Neurosurgery
Volume 133: Pages 947-1284

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Authors: Douglas Kondziolka, William T. Couldwell and James T. Rutka
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Authors: Alain Bouthillier, Alexander G. Weil, Laurence Martineau, Laurent Létourneau-Guillon and Dang Khoa Nguyen

In Brief

This comprehensive study of the effectiveness of operculoinsular cortectomy for refractory epilepsy is, to the authors’ knowledge, the first series of consecutive cases large enough to allow significant conclusions about the effectiveness of this procedure and multivariate analysis of factors associated with success and failure. The authors report the results of 20 years of experience and detailed observations, added to a mean follow-up duration after surgery of 5.8 years, providing information that will be useful to epilepsy centers contemplating this controversial treatment option for highly selected patients with refractory epilepsy.

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Authors: Alain Bouthillier, Alexander G. Weil, Laurence Martineau, Laurent Létourneau-Guillon and Dang Khoa Nguyen

In Brief

This comprehensive study of the safety of operculoinsular cortectomy for refractory epilepsy is, to the authors’ knowledge, the first series of consecutive cases large enough to allow significant conclusions about the rate and types of complications associated with this procedure and multivariate analysis of factors associated with these complications. The reported results and analysis, based on 20 years of experience and detailed observations, will be useful to epilepsy centers contemplating this controversial treatment option for highly selected patients with refractory epilepsy.

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Authors: Qi Yan, Nicolas Gaspard, Hitten P. Zaveri, Hal Blumenfeld, Lawrence J. Hirsch, Dennis D. Spencer and Rafeed Alkawadri

In Brief

In this retrospective study, the authors tested the performance of an interictal metric, which they labeled the connectivity index, for localization, classification, and grading of epileptic brain regions. The results show that this new metric has the potential, if validated prospectively, of supplementing and perhaps replacing the current standard of recording seizures—which present challenges for patients and providers alike—and hence, can enhance quality of care for patients with drug-resistant epilepsy.

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Authors: Christian Dorfer, Arthur Hosmann, Julia Vendl, Irene Steiner, Irene Slavc, Johannes Gojo, Gregor Kasprian and Thomas Czech

In Brief

The authors reviewed clinical and imaging data of patients after transcallosal surgery. Their results may guide physicians in the management of this patient population.

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Authors: Martin Jakobs and Andres M. Lozano
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Authors: Steven W. Cheung, Caroline A. Racine, Jennifer Henderson-Sabes, Carly Demopoulos, Annette M. Molinaro, Susan Heath, Srikantan S. Nagarajan, Andrea L. Bourne, John E. Rietcheck, Sarah S. Wang and Paul S. Larson

In Brief

This study investigated the efficacy and safety outcomes of experimental caudate nucleus deep brain stimulation to treat tinnitus (ringing of the ears) that had been unresponsive or inadequately responsive to standard therapies. The results from this early trial showed clinically significant improvement in 3 of 5 study participants and no safety concerns, providing new hope for tinnitus sufferers.

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Authors: Manish Ranjan, Gavin J. B. Elias, Alexandre Boutet, Jidan Zhong, Powell Chu, Jurgen Germann, Gabriel A. Devenyi, M. Mallar Chakravarty, Alfonso Fasano, Kullervo Hynynen, Nir Lipsman, Clement Hamani, Walter Kucharczyk, Michael L. Schwartz, Andres M. Lozano and Mojgan Hodaie

In Brief

The authors studied a novel tractography method to target the ventral intermediate nucleus (T-VIM) for MRI-guided focused ultrasound (MRgFUS) thalamotomy and compared it with the conventional targeting method to assess its clinical utility and accuracy. The T-VIM coordinates were statistically different from coordinates obtained with the conventional indirect method. The spatial location of the MRgFUS thalamotomy lesion moves away favorably from the adverse effect zone, with T-VIM predicting a favorable clinical profile.

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Authors: Hiroaki Takei, Jun Shinoda, Soko Ikuta, Takashi Maruyama, Yoshihiro Muragaki, Tomohiro Kawasaki, Yuka Ikegame, Makoto Okada, Takeshi Ito, Yoshitaka Asano, Kazutoshi Yokoyama, Noriyuki Nakayama, Hirohito Yano and Toru Iwama

In Brief

The authors used PET imaging to examine the uptake of 3 different tracers to determine the mutation status of gliomas. If preoperative imaging can predict both the genotype and phenotype without the need of a biopsy sample, it will greatly contribute to the determination of subsequent treatment plans for these patients.

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Authors: Nagore I. Marín-Ramos, Marta Pérez-Hernández, Anson Tam, Stephen D. Swenson, Hee-Yeon Cho, Thu Zan Thein, Florence M. Hofman and Thomas C. Chen

In Brief

Current chemotherapy in glioblastoma (GBM) fails to eradicate the glioma stem cells (GSCs), leading to tumor recurrence. The authors have demonstrated that the novel drug NEO100 induces endoplasmic reticulum stress and apoptosis in GSCs, and inhibits their invasiveness via calpain-1/RhoA signaling. In vivo, NEO100 decreases tumor progression and increases patient survival. The data presented here suggest that NEO100 could exhibit significant value targeting GSC and could be used for GBM therapy either as monotherapy or as a coadjuvant therapy in combination with TMZ.

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Authors: Franz Marhold, Petra A. Mercea, Florian Scheichel, Anna S. Berghoff, Patricia Heicappell, Barbara Kiesel, Mario Mischkulnig, Martin Borkovec, Stefan Wolfsberger, Adelheid Woehrer, Matthias Preusser, Engelbert Knosp, Karl Ungersboeck and Georg Widhalm

In Brief

The authors performed an investigation of the fluorescence behavior in cerebral metastases. This study is important because it is the largest series to date of cerebral metastases that were investigated to better clarify the different fluorescence patterns in brain metastases.

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Authors: Satoshi Kiyofuji, Amanda M. Casabella, Christopher S. Graffeo, Avital Perry, James A. Garrity and Michael J. Link

In Brief

The authors report a retrospective, single-institution surgical outcome study of a rare skull base tumor, sphenoorbital meningioma (SOM). Many prior studies have included similar, but different meningiomas, and a study of a pure SOM cohort as in this manuscript is very limited. The authors report excellent improvement of visual impairment and eye protrusion after surgery. They describe the surgical technical details and tumor control, including a strategy for recurrence. This study provides valuable information to neurosurgeons when they encounter this rare tumor.

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Authors: Hirofumi Nakatomi, Jeffrey T. Jacob, Matthew L. Carlson, Shota Tanaka, Minoru Tanaka, Nobuhito Saito, Christine M. Lohse, Colin L. W. Driscoll and Michael J. Link
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Authors: Margaret Y. Mahan and Uzma Samadani
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Authors: Sumit N. Niogi, Neal Luther, Kenneth Kutner, Teena Shetty, Heather J. McCrea, Ronnie Barnes, Leigh Weiss, Russell F. Warren, Scott A. Rodeo, Robert D. Zimmerman, Apostolos John Tsiouris and Roger Härtl

In Brief

The authors conducted an examination of football players using MRI to investigate whether comparing a concussed player’s scan to their own baseline was superior to comparing it to a population of normal healthy adults. This study is important because this data can suggest a better method for assessing concussion.

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Authors: Yanlu Zhang, Michael Chopp, Yi Zhang, Zheng Gang Zhang, Mei Lu, Talan Zhang, Kuan-Han H. Wu, Li Zhang, Asim Mahmood and Ye Xiong

In Brief

There is no clinically effective therapy to enhance brain repair and brain function after traumatic brain injury. The authors designed a prospective, blinded, randomized, and placebo–controlled study to investigate the effects of Cerebrolysin, a neuropeptide preparation, on rats with moderate closed head injury (CHI). The data indicate that Cerebrolysin significantly improves long-term histological and functional outcomes in rats after moderate CHI, with functional outcomes significantly correlated with histological indices of neuroplasticity and neuroprotection.

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Authors: Ho Jun Yi, Jung Eun Lee, Dong Hoon Lee, Young Il Kim, Chul Bum Cho, Il Sup Kim, Jae Hoon Sung and Seung Ho Yang

In Brief

The authors investigated the role of the pyrin domain–containing protein NLRP3 and the pharmacological effects of pioglitazone in mouse models of traumatic brain injury (TBI). The results show that NLRP3 plays a pivotal role in regulating cerebral edema and secondary inflammation and that pioglitazone reduced cerebral edema and the immune response after TBI by downregulating the effects of NLRP3.

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Authors: Andrew Ajisebutu, Marc R. Del Bigio, Colin J. Kazina, Michael West and Demitre Serletis

In Brief

The authors present an overview of the life and times of Dr. Dwight Parkinson, who played a monumental role in developing one of the earliest neurosurgical training programs in mid-Western Canada, and also served as the first president of the Canadian Neurosurgical Society. His contributions to the emerging field of skull base neurosurgery are remarkable, and the authors have been able to gather reliable information from colleagues and trainees who worked with him and knew him best.

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Authors: Bob S. Carter and Fred G. Barker II
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Authors: Michael Karsy, Jian Guan, Ilyas Eli, Andrea A. Brock, Sarah T. Menacho and Min S. Park

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This single-center, double-blinded, placebo-controlled, randomized (1:1) clinical trial was designed to assess the effects on patient outcome of vitamin D supplementation in neurocritical care patients with hypovitaminosis D. Previous research has shown that hypovitaminosis D may predict worse outcomes in neurocritical care patients. The authors’ results suggest vitamin D3 supplementation in neurocritical care patients offers no benefit in hospital or ICU length of stay, as well as no difference in patient complications or disposition.

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Authors: Kristin Sjåvik, Jiri Bartek Jr., Lisa Millgård Sagberg, Marte Lødemel Henriksen, Sasha Gulati, Fredrik L. Ståhl, Helena Kristiansson, Ole Solheim, Petter Förander and Asgeir Store Jakola
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Authors: Tyler Scullen, Mansour Mathkour, John D. Nerva, Aaron S. Dumont and Peter S. Amenta
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Authors: David Hassanein Berro, Vincent L’Allinec, Anne Pasco-Papon, Evelyne Emery, Mada Berro, Charlotte Barbier, Henri-Dominique Fournier and Thomas Gaberel

In Brief

This study compares the results of the two techniques used in the treatment of middle cerebral artery aneurysms, that is, clipping and coiling. Both techniques provide the same clinical outcomes; however, clipping provides more durable and complete exclusion of aneurysms, with fewer recurrences.

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Authors: Simone A. Dijkland, Blessing N. R. Jaja, Mathieu van der Jagt, Bob Roozenbeek, Mervyn D. I. Vergouwen, Jose I. Suarez, James C. Torner, Michael M. Todd, Walter M. van den Bergh, Gustavo Saposnik, Daniel W. Zumofen, Michael D. Cusimano, Stephan A. Mayer, Benjamin W. Y. Lo, Ewout W. Steyerberg, Diederik W. J. Dippel, Tom A. Schweizer, R. Loch Macdonald and Hester F. Lingsma

In Brief

This study was aimed at evaluating the presence and magnitude of between-center and between-country differences in clinical outcomes after aneurysmal subarachnoid hemorrhage in an international cohort and showed significant outcome differences between centers. Gaining insight into differences in patient outcomes between centers and countries is an important first step in evaluating practice variation and eventually improving clinical outcomes after aneurysmal subarachnoid hemorrhage by identifying best practices and informing guidelines.

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Authors: Christopher R. Pasarikovski, Joel Ramjist, Leodante da Costa, Sandra E. Black and Victor Yang
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Authors: Levin Häni, Sonja Vulcu, Mattia Branca, Christian Fung, Werner Josef Z’Graggen, Michael Murek, Andreas Raabe, Jürgen Beck and Philippe Schucht

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The authors compared the outcomes of patients with different locations of drain placement after surgery for chronic subdural hematoma. Chronic subdural hematoma and recurrence are common; thus, the optimal surgical strategy is important.

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Authors: Yi-Chieh Hung, Nasser Mohammed, Thomas Jose Eluvathingal Muttikkal, Kathryn N. Kearns, Chelsea Eileen Li, Aditya Narayan, David Schlesinger, Zhiyuan Xu and Jason P. Sheehan

In Brief

The authors present a retrospective, single-center, case-control study in which de novo arteriovenous malformation (AVM) volume-matched cohorts were used to compare the long-term favorable outcome, obliteration rate, and adverse effects of AVMs treated by embolization plus stereotactic radiosurgery (SRS) and SRS alone. Both embolization plus SRS and SRS alone were effective therapies for moderately large (8–39 ml) AVMs. Even with a significantly higher prescription dose at the time of initial SRS, the embolized group still required more procedures to reach final obliteration.

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Authors: Hiroyuki Kurihara, Koji Yamaguchi, Tatsuya Ishikawa, Takayuki Funatsu, Go Matsuoka, Yoshihiro Omura, Yoshikazu Okada and Takakazu Kawamata

In Brief

Patients with moyamoya disease (MMD) are frequently treated with direct revascularization using superficial temporal artery (STA) to middle cerebral artery (MCA) bypass; however, some patients have poor STA development. The authors report the successful use of direct posterior auricular artery (PAA)–MCA bypass in a series of 4 MMD patients with failed STA development. These results demonstrate that the PAA can be used instead of the STA as a donor artery in direct bypass surgery for MMD.

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Authors: Qing Sun, Xiaochun Zhao, Sirin Gandhi, Ali Tayebi Meybodi, Evgenii Belykh, Daniel Valli, Claudio Cavallo, Leandro Borba Moreira, Peter Nakaji, Michael T. Lawton and Mark C. Preul

In Brief

The authors compared 4 approaches to access the cisternal pulvinar and found the contralateral supracerebellar infratentorial approach to be best for accessing this structure.

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Authors: Visish M. Srinivasan, Joy Gumin, Kevin M. Camstra, Stephen R. Chen, Jeremiah N. Johnson, Yuzaburo Shimizu, Brittany C. Parker Kerrigan, Elizabeth J. Shpall, Frederick F. Lang and Peter Kan

In Brief

The authors present one of the first studies assessing the microcatheter delivery of stem cells. The data presented support further study in this new area of microcatheter neurotherapeutic delivery, including animal and human clinical trials.

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Authors: Franck-Emmanuel Roux, Imène Djidjeli, Romain Quéhan, Emilie Réhault, Carlo Giussani and Jean-Baptiste Durand
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Authors: Ezequiel Goldschmidt, Amir H. Faraji, Brian T. Jankowitz, Paul Gardner and Robert M. Friedlander

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The authors used a commercially available and widely used near-infrared vein finder to localize underlying cortical veins prior to dural opening, which may reduce the likelihood of vascular injury. This simple, inexpensive technique is readily compatible with operative room workflow, necessitates no head fixation or dye, and offers a real-time image independent of brain shift.

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Authors: Cameron A. Elliott, Hayden Danyluk, Keith E. Aronyk, Karolyn Au, B. Matt Wheatley, Donald W. Gross, Tejas Sankar and Christian Beaulieu

In Brief

To improve tracking of the position of important structures during cranial neurosurgery, the authors aimed to correct the geometric distortion and image distortion that accompanies diffusion tensor imaging (DTI). The study is important because the authors demonstrated that a new type of DTI sequence, readout-segmented DTI, decreases these distortions and should be used for intraoperative white matter imaging.

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Authors: Sergio Brasil, Edson Bor-Seng-Shu, Marcelo de-Lima-Oliveira, Fabio Silvio Taccone, Gabriel Gattás, Douglas Mendes Nunes, Raphael A. Gomes de Oliveira, Bruno Martins Tomazini, Paulo Fernando Tierno, Rafael Akira Becker, Estevão Bassi, Luiz Marcelo Sá Malbouisson, Wellingson da Silva Paiva, Manoel Jacobsen Teixeira and Ricardo de Carvalho Nogueira

In Brief

The authors assessed the effectiveness of computed tomography angiography (CTA) for the diagnosis of brain death (BD) and sought to define the optimal tomographic criteria for intracranial circulatory arrest. The results confirm that CTA can reliably support a diagnosis of BD and that the criterion of absence of deep venous opacification can confirm the occurrence of cerebral circulatory arrest, important findings particularly for countries where an ancillary BD test is mandatory and CTA provides an opportunity to improve intensive care strategies and the processes of organ donation and transplantation.

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Authors: Philippe De Vloo, Luka Milosevic, Robert M. Gramer, David Hernán Aguirre-Padilla, Robert F. Dallapiazza, Darrin J. Lee, William D. Hutchison, Alfonso Fasano and Andres M. Lozano
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Authors: Stephen Johnson, Hideyuki Kano, Andrew Faramand, Ajay Niranjan, John C. Flickinger and L. Dade Lunsford

In Brief

The authors retrospectively analyzed data prospectively collected during 30 years of experience to assess the use of the Pittsburgh Hearing Prediction Score (PHPS) to predict long-term hearing outcomes based on age, tumor volume, and hearing status in patients undergoing stereotactic radiosurgery (SRS) for vestibular schwannoma (VS). Serviceable hearing preservation in the setting of VS has become an appropriate management goal, and clinical assessment tools such as the PHPS can better predict hearing preservation rates after SRS.

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Authors: Iyan Younus, Mina M. Gerges, Georgiana A. Dobri, Rohan Ramakrishna and Theodore H. Schwartz

In Brief

The authors assessed risk factors associated with readmission after endoscopic pituitary surgery in a large consecutive series of patients. Important findings were that delayed hyponatremia was the primary cause, accounting for 59% of readmissions, and that a shorter postoperative length of stay and lower BMI were associated with 30-day readmission. Strategies for prevention of delayed hyponatremia may help reduce the frequency of readmissions associated with this complication.

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Authors: Masahiro Shin, Hirotaka Hasegawa, Satoru Miyawaki, Akinobu Kakigi, Tsuguto Takizawa, Kenji Kondo, Taketo Shiode, Taichi Kin and Nobuhito Saito

In Brief

Using the endoscope, the authors could safely remove tumors that invaded deep into the skull base region and that involved the cranial nerves by making a small incision just behind the ear. The surgery could be performed without posing a serious burden to the patients, who would have otherwise required an extensive craniotomy with a large skin incision with a conventional neurosurgical microscope.

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Author: Gillian Shasby
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Authors: Luis Rafael Moscote-Salazar, Alexis Rafael Narvaez-Rojas and Amit Agrawal
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Authors: Tomasz Szmuda, Shan Ali and Paweł Słoniewski
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Authors: Christopher S. Graffeo and Michael T. Lawton
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Authors: Ignazio G. Vetrano and Vittoria Nazzi
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Author: Alex Mamourian
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Authors: Tim E. Darsaut and Jean Raymond
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Authors: Marco Schiariti, Francesco Restelli, Morgan Broggi, Francesco Acerbi, Ignazio Gaspare Vetrano, Andrea Ciuffi, Gabriella Raccuia and Paolo Ferroli
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Authors: Tyler S. Cole and Robert F. Spetzler
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In Brief

This comprehensive study of the effectiveness of operculoinsular cortectomy for refractory epilepsy is, to the authors’ knowledge, the first series of consecutive cases large enough to allow significant conclusions about the effectiveness of this procedure and multivariate analysis of factors associated with success and failure. The authors report the results of 20 years of experience and detailed observations, added to a mean follow-up duration after surgery of 5.8 years, providing information that will be useful to epilepsy centers contemplating this controversial treatment option for highly selected patients with refractory epilepsy.

Restricted access

In Brief

This comprehensive study of the safety of operculoinsular cortectomy for refractory epilepsy is, to the authors’ knowledge, the first series of consecutive cases large enough to allow significant conclusions about the rate and types of complications associated with this procedure and multivariate analysis of factors associated with these complications. The reported results and analysis, based on 20 years of experience and detailed observations, will be useful to epilepsy centers contemplating this controversial treatment option for highly selected patients with refractory epilepsy.

Restricted access

In Brief

In this retrospective study, the authors tested the performance of an interictal metric, which they labeled the connectivity index, for localization, classification, and grading of epileptic brain regions. The results show that this new metric has the potential, if validated prospectively, of supplementing and perhaps replacing the current standard of recording seizures—which present challenges for patients and providers alike—and hence, can enhance quality of care for patients with drug-resistant epilepsy.

Restricted access

In Brief

The authors reviewed clinical and imaging data of patients after transcallosal surgery. Their results may guide physicians in the management of this patient population.

Free access

In Brief

This study investigated the efficacy and safety outcomes of experimental caudate nucleus deep brain stimulation to treat tinnitus (ringing of the ears) that had been unresponsive or inadequately responsive to standard therapies. The results from this early trial showed clinically significant improvement in 3 of 5 study participants and no safety concerns, providing new hope for tinnitus sufferers.

Restricted access

In Brief

The authors studied a novel tractography method to target the ventral intermediate nucleus (T-VIM) for MRI-guided focused ultrasound (MRgFUS) thalamotomy and compared it with the conventional targeting method to assess its clinical utility and accuracy. The T-VIM coordinates were statistically different from coordinates obtained with the conventional indirect method. The spatial location of the MRgFUS thalamotomy lesion moves away favorably from the adverse effect zone, with T-VIM predicting a favorable clinical profile.

Restricted access

In Brief

The authors used PET imaging to examine the uptake of 3 different tracers to determine the mutation status of gliomas. If preoperative imaging can predict both the genotype and phenotype without the need of a biopsy sample, it will greatly contribute to the determination of subsequent treatment plans for these patients.

Restricted access

In Brief

Current chemotherapy in glioblastoma (GBM) fails to eradicate the glioma stem cells (GSCs), leading to tumor recurrence. The authors have demonstrated that the novel drug NEO100 induces endoplasmic reticulum stress and apoptosis in GSCs, and inhibits their invasiveness via calpain-1/RhoA signaling. In vivo, NEO100 decreases tumor progression and increases patient survival. The data presented here suggest that NEO100 could exhibit significant value targeting GSC and could be used for GBM therapy either as monotherapy or as a coadjuvant therapy in combination with TMZ.

Restricted access

In Brief

The authors performed an investigation of the fluorescence behavior in cerebral metastases. This study is important because it is the largest series to date of cerebral metastases that were investigated to better clarify the different fluorescence patterns in brain metastases.

Restricted access

In Brief

The authors report a retrospective, single-institution surgical outcome study of a rare skull base tumor, sphenoorbital meningioma (SOM). Many prior studies have included similar, but different meningiomas, and a study of a pure SOM cohort as in this manuscript is very limited. The authors report excellent improvement of visual impairment and eye protrusion after surgery. They describe the surgical technical details and tumor control, including a strategy for recurrence. This study provides valuable information to neurosurgeons when they encounter this rare tumor.

Restricted access

In Brief

The authors conducted an examination of football players using MRI to investigate whether comparing a concussed player’s scan to their own baseline was superior to comparing it to a population of normal healthy adults. This study is important because this data can suggest a better method for assessing concussion.

Restricted access

In Brief

There is no clinically effective therapy to enhance brain repair and brain function after traumatic brain injury. The authors designed a prospective, blinded, randomized, and placebo–controlled study to investigate the effects of Cerebrolysin, a neuropeptide preparation, on rats with moderate closed head injury (CHI). The data indicate that Cerebrolysin significantly improves long-term histological and functional outcomes in rats after moderate CHI, with functional outcomes significantly correlated with histological indices of neuroplasticity and neuroprotection.

Restricted access

In Brief

The authors investigated the role of the pyrin domain–containing protein NLRP3 and the pharmacological effects of pioglitazone in mouse models of traumatic brain injury (TBI). The results show that NLRP3 plays a pivotal role in regulating cerebral edema and secondary inflammation and that pioglitazone reduced cerebral edema and the immune response after TBI by downregulating the effects of NLRP3.

Restricted access

In Brief

The authors present an overview of the life and times of Dr. Dwight Parkinson, who played a monumental role in developing one of the earliest neurosurgical training programs in mid-Western Canada, and also served as the first president of the Canadian Neurosurgical Society. His contributions to the emerging field of skull base neurosurgery are remarkable, and the authors have been able to gather reliable information from colleagues and trainees who worked with him and knew him best.

Restricted access