Contralesional homotopic functional plasticity in patients with temporal glioma

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OBJECTIVE

This study aimed to explore the contralesional homotopic functional plasticity in the brain of patients with unilateral temporal glioma.

METHODS

Demographic, neurocognitive, and resting-state functional MRI data were collected from 17 patients with temporal glioma (10 in the right lobe and 7 in the left lobe), along with 14 age- and sex-matched healthy controls. The amplitude of low-frequency fluctuation (ALFF) of the contralesional homotopic region and 2 control regions was examined. The region-of-interest–based analysis was used to determine the altered functional connectivity (FC) of the contralesional homotopic region, showing significantly different intrinsic regional brain activity between patients and controls. Partial correlation analysis was conducted to determine the association between the altered neural activity and behavioral characteristics.

RESULTS

Compared with controls, patients with right temporal glioma exhibited significantly increased ALFF in the contralesional homotopic hippocampus and parahippocampal region. In addition, the intrinsic regional activity in these regions was negatively correlated with the visuospatial score (r = −0.718, p = 0.045). Whole-brain FC analysis revealed significantly increased FC between the left hippocampus and parahippocampal regions and the left inferior temporal gyrus, and decreased FC between the left hippocampus and parahippocampal regions and the left inferior frontal gyrus. No significant changes were found in the 2 control regions.

CONCLUSIONS

Contralesional homotopic regions are instrumental in the process of neural plasticity and functional compensation observed in patients with unilateral temporal glioma. The observed findings might be used to help preoperative evaluation or rehabilitation of postsurgical patients.

ABBREVIATIONS ALFF = amplitude of low-frequency fluctuation; DSST = Digital Symbol Substitution Test; FC = functional connectivity; fMRI = functional MRI; GRF = gaussian random field; HGG = high-grade glioma; LGG = low-grade glioma; MNI = Montreal Neurological Institute; ROI = region of interest; TFCE-FWE = threshold-free cluster enhancement family-wise error.

Supplementary Materials

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Article Information

Contributor Notes

Correspondence Hongyi Liu: The Affiliated Brain Hospital of Nanjing Medical University, Jiangsu, China. njnkyylhy@163.com.INCLUDE WHEN CITING Published online January 10, 2020; DOI: 10.3171/2019.11.JNS191982.

D.L., J.C., and X.H. contributed equally to this work and share first authorship.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
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