Attenuation of cerebellar tremor with implantation of an intrathecal baclofen pump: the role of γ-aminobutyric acidergic pathways in cerebellar tremor

Case report

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✓ The authors present the case of a 49-year-old woman with disabling bilateral upper-extremity cerebellar tremor that resolved unexpectedly after placement of an intrathecal baclofen pump for lower-extremity spasticity. The tremor amplitude decreased nearly linearly with increasing intrathecal baclofen dosage, and disappeared completely at a dose of 250 µg/day. In this report the authors demonstrate the role of the γ-aminobutyric acidergic system in the pathogenesis of cerebellar tremor, and these findings may lead to a new treatment modality for patients disabled by this manifestation of their disease.

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Address reprint requests to: Frederick A. Lenz, M.D., Ph.D., Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8–181, Baltimore, Maryland 21287. email: flenz1@jhmi.edu.
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