Preoperative and postoperative cognitive functioning in patients with frontal meningiomas

Restricted access

Object. There is presently no specific information available concerning the nature and course of cognitive deficits caused by intracranial meningiomas. In this prospective study the authors examined the cognitive functioning of patients with frontal meningiomas.

Methods. Fifty-four patients with frontal meningiomas were examined neuropsychologically before and after neurosurgery. The test battery consisted of standardized instruments including those assessing memory, attention, visuoconstructive abilities, and executive functions. The time period between pre-and postoperative assessment ranged from 4 to 9 months. The patients' performance was compared with the results in 54 healthy adults who were also assessed twice by using the same test battery in a period ranging from 4 to 9 months. In addition, the effect on cognition of meningioma lateralization, localization, lesion size, edema, brain compression, time course, and the occurrence of preoperative seizures was analyzed.

Conclusions. Except in the case of working memory, comparisons of pre- and postoperative assessments of cognition revealed no differences in memory, visuoconstructive abilities, or executive functions, although a postoperative improvement in attentional functions was observed. The results of this study indicate that the surgical removal of frontal meningiomas does not impair patients' cognitive functioning. Furthermore, improvements in attentional functions may occur in these patients.

Article Information

Address reprint requests to: Klaus W. Lange, M.D., Ph.D., Institute of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany. email: klaus.lange@psychologie.uni-regensburg.de.

© AANS, except where prohibited by US copyright law.

Headings

References

1.

Andy OJWebster JSCarranza J: Frontal lobe lesions and behavior. South Med J 74:9689721981Andy OJ Webster JS Carranza J: Frontal lobe lesions and behavior. South Med J 74:968–972 1981

2.

Archibald YMLunn DRuttan LAet al: Cognitive functioning in long-term survivors of high-grade glioma. J Neurosurg 80:2472531994Archibald YM Lunn D Ruttan LA et al: Cognitive functioning in long-term survivors of high-grade glioma. J Neurosurg 80:247–253 1994

3.

Armstrong CMollman JCorn BWet al: Effects of radiation therapy on adult brain behavior: evidence for a rebound phenomenon in a phase 1 trial. Neurology 43:196119651993Armstrong C Mollman J Corn BW et al: Effects of radiation therapy on adult brain behavior: evidence for a rebound phenomenon in a phase 1 trial. Neurology 43:1961–1965 1993

4.

Avery TL: Seven cases of frontal tumour with psychiatric presentation. Br J Psychiatry 119:19231971Avery TL: Seven cases of frontal tumour with psychiatric presentation. Br J Psychiatry 119:19–23 1971

5.

Belyi BI: Mental impairment in unilateral frontal tumours: role of the laterality of the lesion. Int J Neurosci 32:7998101987Belyi BI: Mental impairment in unilateral frontal tumours: role of the laterality of the lesion. Int J Neurosci 32:799–810 1987

6.

Benton ALde Hamsher K: ultilingual Aphasia Examination. Iowa City: University of Iowa1976Benton AL de Hamsher K: ultilingual Aphasia Examination. Iowa City: University of Iowa 1976

7.

Butler RWRorsman IHill JMet al: The effects of frontal brain impairment on fluency. Simple and complex paradigms. Neuropsychology 7:5195291993Butler RW Rorsman I Hill JM et al: The effects of frontal brain impairment on fluency. Simple and complex paradigms. Neuropsychology 7:519–529 1993

8.

Cattaino GPomes AQuerin Fet al: Ethmoidal meningioma revealed by transient global amnesia. Ital J Neurol Sci 10:1871911989Cattaino G Pomes A Querin F et al: Ethmoidal meningioma revealed by transient global amnesia. Ital J Neurol Sci 10:187–191 1989

9.

Chan RCThompson GB: Morbidity, mortality, and quality of life following surgery for intracranial meningiomas. A retrospective study in 257 cases. J Neurosurg 60:52601984Chan RC Thompson GB: Morbidity mortality and quality of life following surgery for intracranial meningiomas. A retrospective study in 257 cases. J Neurosurg 60:52–60 1984

10.

Chapman LJChapman JP: The measurement of handedness. Brain Cogn 6:1751831987Chapman LJ Chapman JP: The measurement of handedness. Brain Cogn 6:175–183 1987

11.

Chee CPDavis AGalbraith Set al: Dementia due to meningioma: outcome after surgical removal. Surg Neurol 23:4144161985Chee CP Davis A Galbraith S et al: Dementia due to meningioma: outcome after surgical removal. Surg Neurol 23:414–416 1985

12.

Cicerone KDLazar RMShapiro WR: Effects of frontal lobe lesions on hypothesis sampling during concept formation. Neuropsychologia 21:5135241983Cicerone KD Lazar RM Shapiro WR: Effects of frontal lobe lesions on hypothesis sampling during concept formation. Neuropsychologia 21:513–524 1983

13.

Cohen J: Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: Lawrence Erlbaum1988Cohen J: Statistical Power Analysis for the Behavioral Sciences. Hillsdale NJ: Lawrence Erlbaum 1988

14.

Cohen RA: The Neuropsychology of Attention. New York: Plenum Press1993Cohen RA: The Neuropsychology of Attention. New York: Plenum Press 1993

15.

Corbetta MMiezin FMDobmeyer Set al: Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography. J Neurosci 11:238324021991Corbetta M Miezin FM Dobmeyer S et al: Selective and divided attention during visual discriminations of shape color and speed: functional anatomy by positron emission tomography. J Neurosci 11:2383–2402 1991

16.

Dahl G: WIP: Reduzierter Wechsler-Intelligenztest. Anwendung-Auswertung-Statistische Analysen-Normwerte. Hain: Meisenheim1972Dahl G: WIP: Reduzierter Wechsler-Intelligenztest. Anwendung-Auswertung-Statistische Analysen-Normwerte. Hain: Meisenheim 1972

17.

Dee HLVan Allen MW: Speed of decision-making processes in patients with unilateral cerebral disease. Arch Neurol 28:1631661973Dee HL Van Allen MW: Speed of decision-making processes in patients with unilateral cerebral disease. Arch Neurol 28:163–166 1973

18.

Eslinger PJDamasio AR: Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 35:173117411985Eslinger PJ Damasio AR: Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 35:1731–1741 1985

19.

Fahy STCarey TGOwens JMet al: Psychiatric presentation of frontal meningiomas. Ir J Psychol Med 12:61631995Fahy ST Carey TG Owens JM et al: Psychiatric presentation of frontal meningiomas. Ir J Psychol Med 12:61–63 1995

20.

Feder MRing HSolzi Pet al: Rehabilitation outcomes following craniotomy for intracranial meningiomas. J Neuro Rehab 3:15171989Feder M Ring H Solzi P et al: Rehabilitation outcomes following craniotomy for intracranial meningiomas. J Neuro Rehab 3:15–17 1989

21.

Fischer PASchmidt GWanke Ket al: Neuropsychiatrische und testpsychologische Untersuchungen nach Meningeomoperationen. Fortschr Neurol Psychiatr Grenzgeb 36:1491968Fischer PA Schmidt G Wanke K et al: Neuropsychiatrische und testpsychologische Untersuchungen nach Meningeomoperationen. Fortschr Neurol Psychiatr Grenzgeb 36:1–49 1968

22.

Gomez-Tortosa Edel Barrio ABarroso Tet al: Visual processing disorders in patients with Huntington's disease and asymptomatic carriers. J Neurol 243:2862921996Gomez-Tortosa E del Barrio A Barroso T et al: Visual processing disorders in patients with Huntington's disease and asymptomatic carriers. J Neurol 243:286–292 1996

23.

Goodman AJKumar A: Case report: frontal lobe tumor presenting as late onset depression. Int J Geriatr Psychiatry 7:3773801992Goodman AJ Kumar A: Case report: frontal lobe tumor presenting as late onset depression. Int J Geriatr Psychiatry 7:377–380 1992

24.

Haas JVogt GSchiemann Met al: Aphasia and non-verbal intelligence in brain tumor patients. J Neurol 227:2092181982Haas J Vogt G Schiemann M et al: Aphasia and non-verbal intelligence in brain tumor patients. J Neurol 227:209–218 1982

25.

Hochberg FHSlotnick B: Neuropsychologic impairment in astrocytoma survivors. Neurology 30:1721771980Hochberg FH Slotnick B: Neuropsychologic impairment in astrocytoma survivors. Neurology 30:172–177 1980

26.

Hom JReitan RM: Neuropsychological correlates of rapidly vs. slowly growing intrinsic cerebral neoplasms. J Clin Neuropsychol 6:3093241984Hom J Reitan RM: Neuropsychological correlates of rapidly vs. slowly growing intrinsic cerebral neoplasms. J Clin Neuropsychol 6:309–324 1984

27.

Howell PR: Meningioma misdiagnosed as senile dementia. Lancet 1:6571988 (Letter)Howell PR: Meningioma misdiagnosed as senile dementia. Lancet 1:657 1988 (Letter)

28.

Huber WPoeck KWeniger Det al: Aachener Aphasie Test (AAT). Göttingen: Hogrefe Verlag1983Huber W Poeck K Weniger D et al: Aachener Aphasie Test (AAT). Göttingen: Hogrefe Verlag 1983

29.

Hunter RBlackwood WBull J: Three cases of frontal meningiomas presenting psychiatrically. Br Med J 3:9161968Hunter R Blackwood W Bull J: Three cases of frontal meningiomas presenting psychiatrically. Br Med J 3:9–16 1968

30.

Imperato JPPaleologos NAVick NA: Effects of treatment on long-term survivors with malignant astrocytomas. Ann Neurol 28:8188221990Imperato JP Paleologos NA Vick NA: Effects of treatment on long-term survivors with malignant astrocytomas. Ann Neurol 28:818–822 1990

31.

Keschner MBender MBStrauss I: Mental symptoms associated with brain tumor. A study of 530 verified cases. J Am Med Assoc 110:7147181938Keschner M Bender MB Strauss I: Mental symptoms associated with brain tumor. A study of 530 verified cases. J Am Med Assoc 110:714–718 1938

32.

Lampl YBarak YAchiron Aet al: Intracranial meningiomas: correlation of peritumoral edema and psychiatric disturbances. Psychiatry Res 58:1771801995Lampl Y Barak Y Achiron A et al: Intracranial meningiomas: correlation of peritumoral edema and psychiatric disturbances. Psychiatry Res 58:177–180 1995

33.

Leimkuhler MEMesulam MM: Reversible go-no go deficits in a case of frontal lobe tumor. Ann Neurol 18:6176191985Leimkuhler ME Mesulam MM: Reversible go-no go deficits in a case of frontal lobe tumor. Ann Neurol 18:617–619 1985

34.

Lishman WA: Organic Psychiatry: The Psychological Consequences of Cerebral Disorder. New York: Oxford University Press1978Lishman WA: Organic Psychiatry: The Psychological Consequences of Cerebral Disorder. New York: Oxford University Press 1978

35.

Maeshima SFunahashi KOgura Met al: Unilateral spatial neglect due to right frontal lobe haematoma. J Neurol Neurosurg Psychiatry 57:89931994Maeshima S Funahashi K Ogura M et al: Unilateral spatial neglect due to right frontal lobe haematoma. J Neurol Neurosurg Psychiatry 57:89–93 1994

36.

Maire JPCoudin BGuerin Jet al: Neuropsychologic impairment in adults with brain tumors. Am J Clin Oncol 10:1561621987Maire JP Coudin B Guerin J et al: Neuropsychologic impairment in adults with brain tumors. Am J Clin Oncol 10:156–162 1987

37.

Maurice-Williams RSDunwoody G: Late diagnosis of frontal meningiomas presenting with psychiatric symptoms. Br Med J 296:178517861988Maurice-Williams RS Dunwoody G: Late diagnosis of frontal meningiomas presenting with psychiatric symptoms. Br Med J 296:1785–1786 1988

38.

Meyers CABerman SAScheibel RSet al: Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage. J Psychiatry Neurosci 17:1211251992Meyers CA Berman SA Scheibel RS et al: Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage. J Psychiatry Neurosci 17:121–125 1992

39.

Mirsky AF: The neuropsychology of attention: elements of a complex behavior in Perecman E (ed): Integrating Theory and Practice in Clinical Neuropsychology. Hillsdale: Erlbaum1989Mirsky AF: The neuropsychology of attention: elements of a complex behavior in Perecman E (ed): Integrating Theory and Practice in Clinical Neuropsychology. Hillsdale: Erlbaum 1989

40.

Moses JA JrVinogradov SBerger PA: Serial neuropsychological evaluation of a case of bilateral frontal lobe brain tumor. Int J Clin Neuropsychology 9:1061101987Moses JA Jr Vinogradov S Berger PA: Serial neuropsychological evaluation of a case of bilateral frontal lobe brain tumor. Int J Clin Neuropsychology 9:106–110 1987

41.

Osterrieth PA: Le test de copie d'une figure complexe. Arch Psychologie 30:2063561944Osterrieth PA: Le test de copie d'une figure complexe. Arch Psychologie 30:206–356 1944

42.

Panzer MJDeQuardo JRAbelson JL: Delayed diagnosis of a frontal meningioma. Ann Clin Psychiatry 3:2592621991Panzer MJ DeQuardo JR Abelson JL: Delayed diagnosis of a frontal meningioma. Ann Clin Psychiatry 3:259–262 1991

43.

Price TRPGoetz KLLovell MR: Neuropsychiatric aspects of brain tumors in Yudofsky SCHales RE (eds): Synopsis of Neuropsychiatry. Washington, DC: American Psychiatric Press1994 pp 361379Price TRP Goetz KL Lovell MR: Neuropsychiatric aspects of brain tumors in Yudofsky SC Hales RE (eds): Synopsis of Neuropsychiatry. Washington DC: American Psychiatric Press 1994 pp 361–379

44.

Regard MStrauss EKnapp P: Children's production on verbal and non-verbal fluency tasks. Percept Mot Skills 55:8398441982Regard M Strauss E Knapp P: Children's production on verbal and non-verbal fluency tasks. Percept Mot Skills 55:839–844 1982

45.

Reitan RM: Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 8:2712761958Reitan RM: Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 8:271–276 1958

46.

Rey A: L'examen psychologique dans les cas d'encéphalopahie traumatique. Arch Psychologie 28:2863401941Rey A: L'examen psychologique dans les cas d'encéphalopahie traumatique. Arch Psychologie 28:286–340 1941

47.

Sachsenheimer WPiotrowski WBimmler T: Quality of life in patients with intracranial tumors on the basis of Karnofsky's performance status. J Neurooncol 13:1771811992Sachsenheimer W Piotrowski W Bimmler T: Quality of life in patients with intracranial tumors on the basis of Karnofsky's performance status. J Neurooncol 13:177–181 1992

48.

Salander PKarlsson TBergenheim Tet al: Long-term memory deficits in patients with malignant gliomas. J Neurooncol 25:272381995Salander P Karlsson T Bergenheim T et al: Long-term memory deficits in patients with malignant gliomas. J Neurooncol 25:27–238 1995

49.

Schlesinger B: Mental changes in intracranial tumors and related problems. Confin Neurol 10:2252631950Schlesinger B: Mental changes in intracranial tumors and related problems. Confin Neurol 10:225–263 1950

50.

Selecki BR: Intracranial space-occupying lesions among patients admitted to mental hospitals. Med J Aust 1:3833901965Selecki BR: Intracranial space-occupying lesions among patients admitted to mental hospitals. Med J Aust 1:383–390 1965

51.

Simoca IOlarescu AAJipescu Iet al: Postoperative outcome of intracranial meningiomas; long-term prognosis. Rom J Neurol Psychiatry 32:2372511994Simoca I Olarescu AA Jipescu I et al: Postoperative outcome of intracranial meningiomas; long-term prognosis. Rom J Neurol Psychiatry 32:237–251 1994

52.

Stuss DTBenson DF: The Frontal Lobes. New York: Raven Press1986Stuss DT Benson DF: The Frontal Lobes. New York: Raven Press 1986

53.

Taphoorn MJSchiphorst AKSnoek FJet al: Cognitive functions and quality of life in patients with low-grade gliomas: the impact of radiotherapy. Ann Neurol 36:48541994Taphoorn MJ Schiphorst AK Snoek FJ et al: Cognitive functions and quality of life in patients with low-grade gliomas: the impact of radiotherapy. Ann Neurol 36:48–54 1994

54.

Trittmacher STraupe HSchmid A: Pre- and postoperative changes in brain tissue surrounding a meningioma. Neurosurgery 22:8828851988Trittmacher S Traupe H Schmid A: Pre- and postoperative changes in brain tissue surrounding a meningioma. Neurosurgery 22:882–885 1988

55.

Tucha OSmely CPreier Met al: Cognitive deficits before treatment among patients with brain tumors. Neurosurgery 47:3243342000Tucha O Smely C Preier M et al: Cognitive deficits before treatment among patients with brain tumors. Neurosurgery 47:324–334 2000

56.

Tucha OWSmely CWLange KW: Verbal and figural fluency in patients with mass lesions of the left or right frontal lobes. J Clin Exp Neuropsychol 21:2292361999Tucha OW Smely CW Lange KW: Verbal and figural fluency in patients with mass lesions of the left or right frontal lobes. J Clin Exp Neuropsychol 21:229–236 1999

57.

van Zomeren AHBrouwer WH: Clinical Neuropsychology of Attention. New York: Oxford University Press1994van Zomeren AH Brouwer WH: Clinical Neuropsychology of Attention. New York: Oxford University Press 1994

58.

Wechsler D: Wechsler Adult Intelligence Scale-Revised. San Antonio: Psychological Corporation1981Wechsler D: Wechsler Adult Intelligence Scale-Revised. San Antonio: Psychological Corporation 1981

59.

Zimmermann PFimm B: Testbatterie zur Aufmerksamkeitsprüfung (TAP) Version 1.02c. Herzogenrath: Psychologische Testsysteme1989Zimmermann P Fimm B: Testbatterie zur Aufmerksamkeitsprüfung (TAP) Version 1.02c. Herzogenrath: Psychologische Testsysteme 1989

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 50 50 16
Full Text Views 205 205 26
PDF Downloads 107 107 9
EPUB Downloads 0 0 0

PubMed

Google Scholar