Comparative genomic hybridization analysis of craniopharyngiomas

View More View Less
  • 1 Danek Gertner Institute of Genetics, Susanne Levy Gertner Oncogenetics Unit, and Chaim Sheba Medical Center, Tel-Hashomer; Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel; and Pharmaceutical Sciences Research Institute, Aston University, Birmingham, United Kingdom
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00
Print or Print + Online

Object. Craniopharyngioma is the most common childhood brain tumor and is thought to arise from embryonic remnants of the Rathke pouch. Some craniopharyngiomas are monoclonal in origin and hence presumably harbor somatic genetic alterations, although the precise molecular mechanisms involved in craniopharyngioma development are unknown. The goal of this study was to identify genetic alterations in craniopharyngiomas.

Methods. To gain insight into the molecular mechanisms involved in development of these tumors, the authors analyzed nine adamantinomatous craniopharyngiomas by using comparative genomic hybridization. Six tumors (67%) displayed at least one genomic alteration, and three had six or more alterations. Only two tumors displayed a decrease in DNA copy number, and in all others an increase in DNA copy number was noted.

Conclusions. The authors conclude that a subset of craniopharyngiomas consists of monoclonal tumors arising from activation of oncogenes located at specific chromosomal loci.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00

Contributor Notes

Address reprint requests to: Eitan Friedman, M.D., Ph.D., Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel 52621. email: eitan211@ sheba.health.gov.il.
  • 1.

    Banna M: Craniopharyngiomas: based on 160 cases. Br J Radiol 49:206223, 1976 Banna M: Craniopharyngiomas: based on 160 cases. Br J Radiol 49:206–223, 1976

    • Search Google Scholar
    • Export Citation
  • 2.

    Bryndorf T, , Kirchhoff M, & Rose H, et al: Comparative genomic hybridization in clinical cytogenetics. Am J Hum Genet 57:12111220, 1995 Bryndorf T, Kirchhoff M, Rose H, et al: Comparative genomic hybridization in clinical cytogenetics. Am J Hum Genet 57:1211–1220, 1995

    • Search Google Scholar
    • Export Citation
  • 3.

    Bunin GR, , Surawicz TS, & Witman PA, et al: The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547551, 1998 Bunin GR, Surawicz TS, Witman PA, et al: The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551, 1998

    • Search Google Scholar
    • Export Citation
  • 4.

    Daniely M, , Aviram A, & Adams EF, et al: Comparative genomic hybridization analysis of nonfunctioning pituitary tumors. J Clin Endocrinol Metab 83:18011805, 1998 Daniely M, Aviram A, Adams EF, et al: Comparative genomic hybridization analysis of nonfunctioning pituitary tumors. J Clin Endocrinol Metab 83:1801–1805, 1998

    • Search Google Scholar
    • Export Citation
  • 5.

    Davis LG, , Dibner MD, & Battey JF: Methods in Molecular Biology. New York: Elsevier, 1986, pp 4243 Davis LG, Dibner MD, Battey JF: Methods in Molecular Biology. New York: Elsevier, 1986, pp 42–43

    • Search Google Scholar
    • Export Citation
  • 6.

    Gorski GK, , McMorrow LE, & Donaldson MH, et al: Multiple chromosomal abnormalities in a case of craniopharyngioma. Cancer Genet Cytogenet 60:212213, 1992 (Letter) Gorski GK, McMorrow LE, Donaldson MH, et al: Multiple chromosomal abnormalities in a case of craniopharyngioma. Cancer Genet Cytogenet 60:212–213, 1992 (Letter)

    • Search Google Scholar
    • Export Citation
  • 7.

    Infobiogen: Atlas of Genetics and Cytogenetics in Oncology and Haematology. (http://www.infobiogen.fr/services/chromcancer/) [Accessed 24 October 2002] Infobiogen: Atlas of Genetics and Cytogenetics in Oncology and Haematology. (http://www.infobiogen.fr/services/chromcancer/) [Accessed 24 October 2002]

    • Search Google Scholar
    • Export Citation
  • 8.

    Karnes PS, , Tran TN, & Cui MY, et al: Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 59:1219, 1992 Karnes PS, Tran TN, Cui MY, et al: Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 59:12–19, 1992

    • Search Google Scholar
    • Export Citation
  • 9.

    Kleihues P, , Burger PC, & Scheithauer BW: Histological Typing of Tumours of the Central Nervous System, ed 2. Berlin: Springer-Verlag, 1993 Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumours of the Central Nervous System, ed 2. Berlin: Springer-Verlag, 1993

    • Search Google Scholar
    • Export Citation
  • 10.

    Ramaswamy S, & Golub TR: DNA microarrays in clinical oncology. J Clin Oncol 20:19321941, 2002 Ramaswamy S, Golub TR: DNA microarrays in clinical oncology. J Clin Oncol 20:1932–1941, 2002

    • Search Google Scholar
    • Export Citation
  • 11.

    Sarubi JC, , Bei H, & Adams EF, et al: Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsα and Gi2α genes. Neurosci Lett 310:58, 2001 Sarubi JC, Bei H, Adams EF, et al: Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsα and Gi2α genes. Neurosci Lett 310:5–8, 2001

    • Search Google Scholar
    • Export Citation
  • 12.

    Shin JL, , Asa AL, & Woodhouse LJ, et al: Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst. J Clin Endocrinol Metab 84:39723982, 1999 Shin JL, Asa AL, Woodhouse LJ, et al: Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst. J Clin Endocrinol Metab 84:3972–3982, 1999

    • Search Google Scholar
    • Export Citation
  • 13.

    Vagner-Capodano AM, , Gentet JC, & Gambarelli D, et al: Cytogenetic studies in 45 pediatric brain tumors. Pediatr Hematol Oncol 9:223235, 1992 Vagner-Capodano AM, Gentet JC, Gambarelli D, et al: Cytogenetic studies in 45 pediatric brain tumors. Pediatr Hematol Oncol 9:223–235, 1992

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 176 111 6
Full Text Views 145 6 0
PDF Downloads 92 3 0
EPUB Downloads 0 0 0