We recently introduced a new method in which we use 5-ALA for intraoperative visualization of malignant glioma tissue, which is now being routinely used in our department.33–35 A metabolic precursor, 5-ALA leads to accumulation of fluorescent porphyrins in malignant glioma tissue, a phenomenon exploitable for improving tumor resection.35 We analyze the data obtained in a series of 52 consecutive patients with GBM who were treated according to a prospective protocol to determine whether the procedure, besides improving the completeness of resection, may afford a survival benefit for patients.
We gratefully acknowledge the ongoing support of Dr. Reinhold Baumgartner and Susanne Stocker, Ph.D., Laser Research Laboratory, Ludwig-Maximilians-University. We thank the Carl Zeiss (Oberkochen, Germany) and Karl Storz (Tuttlingen, Germany) companies for their generous support with donations, including microscope filter and illumination equipment, throughout the course of this investigation.
Simpson JRHorton JScott Cet al: Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26:239–2441993Int J Radiat Oncol Biol Phys 26:
Vecht CJAvezaat CJJvan Putten WLJet al: The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients. J Neurol Neurosurg Psychiatry 53:466–4711990J Neurol Neurosurg Psychiatry 53:
Yoshida JKajita YWakabayashi Tet al: Long-term follow-up results of 175 patients with malignant glioma: importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation. Acta Neurochir 127:55–591994Acta Neurochir 127: