Although previous work has demonstrated the feasibility of convective delivery in the CNS and shown that the Vi and target location (gray as opposed to white matter) influence distribution, other parameters that affect this method of substance delivery have not been determined. Critical variables that could potentially affect convective delivery include rate of infusate delivery, delivery cannula size, concentration of infusate, and preinfusion sealing time around the cannula. To determine how and whether these variables affect convective delivery, we systematically examined their effect on the Vd, percentage of recovery, and infusate leakback.
Neuwelt EALawrence MSBlank NK: Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation. Neurosurgery 15:475–4831984Escherichia coli brain abscess model with histopathological correlation. Neurosurgery 15: