Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973–1991

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Object. The authors present population-based survival rate estimates for patients with malignant primary brain tumors based on an analysis of 18 years of data obtained from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute.

Methods. Estimates of survival rates at 2 and 5 years after diagnosis for patients with specific histological tumor types were categorized by patient's age at diagnosis (≤ 20 years, 21–64 years, and 65 years or older) and by the time period in which the patients were diagnosed (1973–1980, 1981–1985, 1986–1991). Where appropriate, survival estimates were adjusted for changing patterns in the mean age at diagnosis.

Conclusions. The authors observed a pattern of declining survival rates in patients with increasing age of the patient at diagnosis for most histological groups and overall improvements in survival rates of patients across these time periods adjusting for age at diagnosis. There were improvements in 2- and 5-year survival rates over the three time periods for children and adults with medulloblastoma and for adults with astrocytoma and oligodendroglioma. Improvements in survival rates for pediatric patients with medulloblastoma have leveled off in the most recent time period, and gender differences in survival rates for patients with this tumor, which were present in the 1970s, have disappeared. Clinically significant improvements in survival rates were not apparent in patients aged 65 years and older.

Changes in diagnostic and treatment procedures since the mid-1970s have resulted in improved survival rates for patients diagnosed as having medulloblastoma, oligodendroglioma, and astrocytoma, controlling for age at diagnosis. Glioblastoma multiforme continues to be the most intractable brain tumor.

Article Information

Address reprint requests to: Faith G. Davis, Ph.D., Division of Epidemiology and Biostatistics (MC 922), School of Public Health, 2121 West Taylor Street, Room 505, University of Illinois at Chicago, Chicago, Illinois 60612–7260.

© AANS, except where prohibited by US copyright law."

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Figures

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    Bar graph displaying 5-year survival rates for patients with primary brain cancers according to patient age and tumor type. Raw data were obtained from the SEER program and cover the time period 1973 to 1991.

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    Bar graphs showing survival rates for pediatric (0–20 years of age) and adult (21–64 years of age) patients with medulloblastoma. Raw data were obtained from the SEER program and cover the time period 1973 to 1991. **Rates are adjusted for mean age at diagnosis.

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    Bar graphs depicting survival rates for adult patients (21–64 years of age) with brain cancers. Raw data were obtained from the SEER program and cover the time period 1973 to 1991. **Rates are adjusted for mean age at diagnosis.

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    Graph showing survival curves for patients with cancers diagnosed from 1981 to 1991. Raw data were obtained from the SEER program.

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