Rat models have confirmed that venous hypertension64 and sagittal sinus thrombosis24 elicit the formation of dural AVMs. Such animal models enable the study of events leading to the formation of dural AVMs before gross histological changes are apparent—a window of observation lacking in the clinical setting. No laboratory investigation has thus far demonstrated angiogenic activity in the development of dural AVMs: the notion has been purely speculative. This study, however, provides the first experimental evidence supporting angiogenesis as a mechanism of dural AVM formation.
We gratefully acknowledge Adrienne C. Scheck, Ph.D., for reviewing the manuscript, John Pemberton and Conrad Ballecer for their technical support, Robert Amos for filming angiograms, Stacy Ruzicka for photographic assistance, Shelley A. Kick, Ph.D., Senior Editor, for her editorial expertise, and the Neuroscience Publications Office for editorial assistance.
Folkman J: How is blood vessel growth regulated in normal and neoplastic tissue?—G.H.A. Clowes Memorial Award Lecture. Cancer Res 46:467–4731986Folkman J: How is blood vessel growth regulated in normal and neoplastic tissue?—G.H.A. Clowes Memorial Award Lecture. Cancer Res 46:
Dr. Lawton is recipient of the 1997 World Federation of Neurosurgical Societies Young Neurosurgeon Award, presented at the 11th International Congress of Neurological Surgeons, July 6–11, 1997, Amsterdam, The Netherlands.