Paradoxical effects of acute ethanolism in experimental brain injury

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  • 1 Division of Neurosurgery, Brain Injury Research Center, Brain Research Institute, and Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, California
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✓ Acute ethanol intoxication is a frequent complicating factor in human head injury, yet its impact on neurological outcome remains poorly defined. This study was undertaken to assess the effect of varying levels of preinjury ethanol on early postinjury mortality, recovery of motor function, and degree of neural degeneration after cortical contusion injury in the rat. Adult rats were pretrained on a beam-walking task, then randomized to one of five groups: low-dose ethanol and injury (1 g/kg, 16 animals); moderate-dose ethanol and injury (2.5 g/kg, 11 animals); high-dose ethanol and injury (3 g/kg, 17 animals); no ethanol and injury (nine animals); or ethanol and sham injury (seven animals). Forty minutes after intraperitoneal injection of ethanol or saline, the rats received a pneumatic piston—induced contusion injury of the left primary motor cortex. Their beam-walking ability was assessed daily for the next 7 days. At 4 weeks postinjury, the brains were sectioned and the dimensions of the cortical lesions were determined.

Preinjury ethanol administration was associated with an acute postinjury mortality rate of 29.5% (p < 0.05); the highest mortality rate (47.1%) occurred in the high-dose ethanol group, whereas no deaths occurred in the animals in the no ethanol or sham-injured groups (p < 0.01). However, injured animals receiving low- and moderate-dose ethanol had significantly less severe beam-walking impairment initially, and a more rapid return to normal beam-walking ability, compared to the no and high-dose ethanol groups (p < 0.05). Additionally, the mean lesion volumes were significantly smaller in the low- and moderate-dose ethanol treatment groups compared to the no and high-dose ethanol groups (23.2 ± 8 mm3 and 29 ± 6.7 mm3 vs. 52 ± 8.8 mm3 and 53.7 ± 10.9 mm3, respectively, p < 0.01). In this cortical contusion model, the presence of ethanol before injury appears to exert a potent neuroprotective effect when administered in low or moderate doses. This action is postulated to result from ethanol-induced inhibition of N-methyl-d-aspartate receptor-mediated excitotoxicity. The loss of neuroprotection and increased mortality rates observed with high-dose ethanol may be related to ethanol-induced hemodynamic and respiratory depression.

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Contributor Notes

Address reprint requests to: Daniel F. Kelly, M.D., Division of Neurosurgery, University of California at Los Angeles, Room 18–218A NPI, Box 957039, Los Angeles, California 90095–7039.
  • 1.

    Abel EL, & York JL: Age-related differences in response to ethanol in the rat. Physiol Psychol 7:391395, 1979 Abel EL, York JL: Age-related differences in response to ethanol in the rat. Physiol Psychol 7:391–395, 1979

    • Search Google Scholar
    • Export Citation
  • 2.

    Albin MS, & Bunegin L: An experimental study of craniocerebral trauma during ethanol intoxication. Crit Care Med 14:841846, 1986 Albin MS, Bunegin L: An experimental study of craniocerebral trauma during ethanol intoxication. Crit Care Med 14:841–846, 1986

    • Search Google Scholar
    • Export Citation
  • 3.

    Bengmark S, , Göransson G, & Idvall J, et al: Increased bleeding during liver resection in ethanol-intoxicated rats. Thromb Hemostas 43:203207, 1980 Bengmark S, Göransson G, Idvall J, et al: Increased bleeding during liver resection in ethanol-intoxicated rats. Thromb Hemostas 43:203–207, 1980

    • Search Google Scholar
    • Export Citation
  • 4.

    Bloom F, , Lad P, & Pittman Q, et al: Blood alcohol levels in rats: non-uniform yields from intraperitoneal doses based on body weight. Br J Pharmacol 75:251254, 1982 Bloom F, Lad P, Pittman Q, et al: Blood alcohol levels in rats: non-uniform yields from intraperitoneal doses based on body weight. Br J Pharmacol 75:251–254, 1982

    • Search Google Scholar
    • Export Citation
  • 5.

    Brooks N, , Symington C, & Beattie A, et al: Alcohol and other predictors of cognitive recovery after severe head injury. Brain Inj 3:235246, 1989 Brooks N, Symington C, Beattie A, et al: Alcohol and other predictors of cognitive recovery after severe head injury. Brain Inj 3:235–246, 1989

    • Search Google Scholar
    • Export Citation
  • 6.

    Bullock R, , Hannemann CO, & Murray L, et al: Recurrent hematomas following craniotomy for traumatic intracranial mass. J Neurosurg 72:914, 1990 Bullock R, Hannemann CO, Murray L, et al: Recurrent hematomas following craniotomy for traumatic intracranial mass. J Neurosurg 72:9–14, 1990

    • Search Google Scholar
    • Export Citation
  • 7.

    Chandler LJ, , Sumners C, & Crews FT: Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcohol Clin Exp Res 17:5460, 1993 Chandler LJ, Sumners C, Crews FT: Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcohol Clin Exp Res 17:54–60, 1993

    • Search Google Scholar
    • Export Citation
  • 8.

    DeCrescito V, , Demopoulos HB, & Flamm ES, et al: Ethanol potentiation of traumatic cerebral edema. Surg Forum 25:438440, 1974 DeCrescito V, Demopoulos HB, Flamm ES, et al: Ethanol potentiation of traumatic cerebral edema. Surg Forum 25:438–440, 1974

    • Search Google Scholar
    • Export Citation
  • 9.

    Deykin D, , Janson P, & McMahon L: Ethanol potentiation of aspirin-induced prolongation of the bleeding time. N Engl J Med 306:852854, 1982 Deykin D, Janson P, McMahon L: Ethanol potentiation of aspirin-induced prolongation of the bleeding time. N Engl J Med 306:852–854, 1982

    • Search Google Scholar
    • Export Citation
  • 10.

    Dildy-Mayfield JE, & Leslie SW: Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol. J Neurochem 56:15361543, 1991 Dildy-Mayfield JE, Leslie SW: Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol. J Neurochem 56:1536–1543, 1991

    • Search Google Scholar
    • Export Citation
  • 11.

    Dixon CE, , Clifton GL, & Lighthall JW, et al: A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Meth 39:253262, 1991 Dixon CE, Clifton GL, Lighthall JW, et al: A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Meth 39:253–262, 1991

    • Search Google Scholar
    • Export Citation
  • 12.

    Elmér O, , Göransson G, & Zoucas E: Impairment of primary hemostasis and platelet function after alcohol ingestion in man. Haemostasis 14:223228, 1984 Elmér O, Göransson G, Zoucas E: Impairment of primary hemostasis and platelet function after alcohol ingestion in man. Haemostasis 14:223–228, 1984

    • Search Google Scholar
    • Export Citation
  • 13.

    Feeney DM, , Gonzalez A, & Law WA: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 217:855857, 1982 Feeney DM, Gonzalez A, Law WA: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science 217:855–857, 1982

    • Search Google Scholar
    • Export Citation
  • 14.

    Ferraro TN, , Weyers P, & Carrozza DP, et al: Continuous monitoring of brain ethanol levels by intracerebral microdialysis. Alcohol 7:129132, 1990 Ferraro TN, Weyers P, Carrozza DP, et al: Continuous monitoring of brain ethanol levels by intracerebral microdialysis. Alcohol 7:129–132, 1990

    • Search Google Scholar
    • Export Citation
  • 15.

    Fineman I, , Hovda DA, & Smith M, et al: Concussive brain injury is associated with a prolonged accumulation of calcium: a 45calcium autoradiographic study. Brain Res 624:94102, 1993 Fineman I, Hovda DA, Smith M, et al: Concussive brain injury is associated with a prolonged accumulation of calcium: a 45calcium autoradiographic study. Brain Res 624:94–102, 1993

    • Search Google Scholar
    • Export Citation
  • 16.

    Flamm ES, , Demopoulos HB, & Seligman ML, et al: Ethanol potentiation of central nervous system trauma. J Neurosurg 46:328335, 1977 Flamm ES, Demopoulos HB, Seligman ML, et al: Ethanol potentiation of central nervous system trauma. J Neurosurg 46:328–335, 1977

    • Search Google Scholar
    • Export Citation
  • 17.

    Franco CD, , Spillert CR, & Spillert KR, et al: Alcohol increases mortality in murine head injury. J Natl Med Assoc 80:6364, 1988 Franco CD, Spillert CR, Spillert KR, et al: Alcohol increases mortality in murine head injury. J Natl Med Assoc 80:63–64, 1988

    • Search Google Scholar
    • Export Citation
  • 18.

    Haut MJ, & Cowan DH: The effect of ethanol on hemostatic properties of human blood platelets. Am J Med 56:2233, 1974 Haut MJ, Cowan DH: The effect of ethanol on hemostatic properties of human blood platelets. Am J Med 56:22–33, 1974

    • Search Google Scholar
    • Export Citation
  • 19.

    Hoffman PL, , Rabe CS, & Moses F, et al: N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem 52:19371940, 1989 Hoffman PL, Rabe CS, Moses F, et al: N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem 52:1937–1940, 1989

    • Search Google Scholar
    • Export Citation
  • 20.

    Hofstede DJ, , Bullock R, & Povlishock JT: Ultrastructural analyses of pericontusional tissue harvested from foci of known glutamate and cerebral blood flow levels. J Neurotrauma 12:974, 1995 (Abstract) Hofstede DJ, Bullock R, Povlishock JT: Ultrastructural analyses of pericontusional tissue harvested from foci of known glutamate and cerebral blood flow levels. J Neurotrauma 12:974, 1995 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 21.

    Hovda DA, , Lee SM, & Smith ML, et al: The neurochemical and metabolic cascade following brain injury: moving from animal models to man. J Neurotrauma 12:903906, 1995 Hovda DA, Lee SM, Smith ML, et al: The neurochemical and metabolic cascade following brain injury: moving from animal models to man. J Neurotrauma 12:903–906, 1995

    • Search Google Scholar
    • Export Citation
  • 22.

    Inglis FM, , Bullock R, & Chen MH, et al: Ischaemic brain damage associated with tissue hypermetabolism in acute subdural hematoma: reduction by a glutamate antagonist. Acta Neurochir Suppl 51:277279, 1990 Inglis FM, Bullock R, Chen MH, et al: Ischaemic brain damage associated with tissue hypermetabolism in acute subdural hematoma: reduction by a glutamate antagonist. Acta Neurochir Suppl 51:277–279, 1990

    • Search Google Scholar
    • Export Citation
  • 23.

    Katayama Y, , Becker DP, & Tamura T, et al: Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 73:889900, 1990 Katayama Y, Becker DP, Tamura T, et al: Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 73:889–900, 1990

    • Search Google Scholar
    • Export Citation
  • 24.

    Kawamata T, , Katayama Y, & Hovda DA, et al: Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury. J Cereb Blood Flow Metab 12:1224, 1992 Kawamata T, Katayama Y, Hovda DA, et al: Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury. J Cereb Blood Flow Metab 12:12–24, 1992

    • Search Google Scholar
    • Export Citation
  • 25.

    Kawamata T, , Katayama Y, & Hovda DA, et al: Lactate accumulation following concussive brain injury: the role of ionic fluxes induced by excitatory amino acids. Brain Res 674:196204, 1995 Kawamata T, Katayama Y, Hovda DA, et al: Lactate accumulation following concussive brain injury: the role of ionic fluxes induced by excitatory amino acids. Brain Res 674:196–204, 1995

    • Search Google Scholar
    • Export Citation
  • 26.

    Kelly DF: Alcohol and head injury: an issue revisited. J Neurotrauma 12:883890, 1995 Kelly DF: Alcohol and head injury: an issue revisited. J Neurotrauma 12:883–890, 1995

    • Search Google Scholar
    • Export Citation
  • 27.

    Kelly DF, , Herr DL, & Kemmerle-Pierre C, et al: Effects of acute alcohol intoxication on outcome of head injury. Crit Care Med 23 (Suppl):A245, 1995 (Abstract) Kelly DF, Herr DL, Kemmerle-Pierre C, et al: Effects of acute alcohol intoxication on outcome of head injury. Crit Care Med 23 (Suppl):A245, 1995 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 28.

    Kraus JF: Epidemiology of head injury, in Cooper PR (ed): Head Injury, ed 3. Baltimore: Williams & Wilkins, 1993, pp 125 Kraus JF: Epidemiology of head injury, in Cooper PR (ed): Head Injury, ed 3. Baltimore: Williams & Wilkins, 1993, pp 1–25

    • Search Google Scholar
    • Export Citation
  • 29.

    Kraus JF, , Morgenstern H, & Fife D, et al: Blood alcohol tests, prevalence of involvement, and outcomes following brain injury. Am J Public Health 79:294299, 1989 Kraus JF, Morgenstern H, Fife D, et al: Blood alcohol tests, prevalence of involvement, and outcomes following brain injury. Am J Public Health 79:294–299, 1989

    • Search Google Scholar
    • Export Citation
  • 30.

    Kuroda Y, , Inglis FM, & Miller JD, et al: Transient glucose hypermetabolism after acute subdural hematoma in the rat. J Neurosurg 76:471477, 1992 Kuroda Y, Inglis FM, Miller JD, et al: Transient glucose hypermetabolism after acute subdural hematoma in the rat. J Neurosurg 76:471–477, 1992

    • Search Google Scholar
    • Export Citation
  • 31.

    Lee SM, , Lifshitz J, & Hovda DA, et al: Focal cortical impact injury produces immediate and persistent deficits in metabolic autoregulation. J Cereb Blood Flow Metab 15 (Suppl 1):S722, 1995 (Abstract) Lee SM, Lifshitz J, Hovda DA, et al: Focal cortical impact injury produces immediate and persistent deficits in metabolic autoregulation. J Cereb Blood Flow Metab 15 (Suppl 1):S722, 1995 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 32.

    Lovinger DM: Excitotoxicity and alcohol-related brain damage. Alcohol Clin Exp Res 17:1927, 1993 Lovinger DM: Excitotoxicity and alcohol-related brain damage. Alcohol Clin Exp Res 17:19–27, 1993

    • Search Google Scholar
    • Export Citation
  • 33.

    Lovinger DM, , White G, & Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:17211724, 1989 Lovinger DM, White G, Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721–1724, 1989

    • Search Google Scholar
    • Export Citation
  • 34.

    Luna GK, , Maier RV, & Sowder L, et al: The influence of ethanol intoxication on outcome of injured motorcyclists. J Trauma 24:695700, 1984 Luna GK, Maier RV, Sowder L, et al: The influence of ethanol intoxication on outcome of injured motorcyclists. J Trauma 24:695–700, 1984

    • Search Google Scholar
    • Export Citation
  • 35.

    McQueen JD, & Posey JB: Changes in intracranial pressure and brain hydration during acute ethanolism. Surg Neurol 4:375379, 1975 McQueen JD, Posey JB: Changes in intracranial pressure and brain hydration during acute ethanolism. Surg Neurol 4:375–379, 1975

    • Search Google Scholar
    • Export Citation
  • 36.

    Modell JG, & Mountz JM.: Drinking and flying—the problem of alcohol use by pilots. N Engl J Med 323:455461, 1990 Modell JG, Mountz JM.: Drinking and flying—the problem of alcohol use by pilots. N Engl J Med 323:455–461, 1990

    • Search Google Scholar
    • Export Citation
  • 37.

    Nilsson P, , Hillered L, & Olsson Y, et al: Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats. J Cereb Blood Flow Metab 13:183192, 1993 Nilsson P, Hillered L, Olsson Y, et al: Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats. J Cereb Blood Flow Metab 13:183–192, 1993

    • Search Google Scholar
    • Export Citation
  • 38.

    Okiyami K, , Smith DH, & Thomas MJ, et al: Evaluation of a novel calcium channel blocker, (s)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury. J Neurosurg 77:607615, 1992 Okiyami K, Smith DH, Thomas MJ, et al: Evaluation of a novel calcium channel blocker, (s)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury. J Neurosurg 77:607–615, 1992

    • Search Google Scholar
    • Export Citation
  • 39.

    Olson JD, , Kaufman HH, & Moake J, et al: The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery 24:825832, 1989 Olson JD, Kaufman HH, Moake J, et al: The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery 24:825–832, 1989

    • Search Google Scholar
    • Export Citation
  • 40.

    Ott JF, , Hunter BE, & Walker DW: The effect of age on ethanol metabolism and on the hypothermic and hypnotic responses to ethanol in the Fischer 344 rat. Alcohol Clin Exp Res 9:5965, 1985 Ott JF, Hunter BE, Walker DW: The effect of age on ethanol metabolism and on the hypothermic and hypnotic responses to ethanol in the Fischer 344 rat. Alcohol Clin Exp Res 9:59–65, 1985

    • Search Google Scholar
    • Export Citation
  • 41.

    Palmer AM, , Marion DW, & Botscheller ML, et al: Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J Neurochem 61:20152024, 1993 Palmer AM, Marion DW, Botscheller ML, et al: Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J Neurochem 61:2015–2024, 1993

    • Search Google Scholar
    • Export Citation
  • 42.

    Persson L, & Rosengren L: Increased blood-brain barrier permeability around cerebral stab wounds, aggravated by acute ethanol intoxication. Acta Neurol Scand 56:716, 1977 Persson L, Rosengren L: Increased blood-brain barrier permeability around cerebral stab wounds, aggravated by acute ethanol intoxication. Acta Neurol Scand 56:7–16, 1977

    • Search Google Scholar
    • Export Citation
  • 43.

    Rimel RW, , Giordani B, & Barth JT: Moderate head injury: completing the clinical spectrum of brain trauma. Neurosurgery 11:344351, 1982 Rimel RW, Giordani B, Barth JT: Moderate head injury: completing the clinical spectrum of brain trauma. Neurosurgery 11:344–351, 1982

    • Search Google Scholar
    • Export Citation
  • 44.

    Rimel RW, , Giordani B, & Barth JT, et al: Disability caused by minor head injury. Neurosurgery 9:221228, 1981 Rimel RW, Giordani B, Barth JT, et al: Disability caused by minor head injury. Neurosurgery 9:221–228, 1981

    • Search Google Scholar
    • Export Citation
  • 45.

    Roine RP, , Gentry RT, & Lim RT Jr, et al: Effect of concentration of ingested ethanol on blood alcohol levels. Alcohol Clin Exp Res 15:734738, 1991 Roine RP, Gentry RT, Lim RT Jr, et al: Effect of concentration of ingested ethanol on blood alcohol levels. Alcohol Clin Exp Res 15:734–738, 1991

    • Search Google Scholar
    • Export Citation
  • 46.

    Ruff RM, , Marshall LF, & Klauber MR, et al: Alcohol abuse and neurological outcome of the severely head injured. J Head Trauma Rehab 5:2131, 1990 Ruff RM, Marshall LF, Klauber MR, et al: Alcohol abuse and neurological outcome of the severely head injured. J Head Trauma Rehab 5:21–31, 1990

    • Search Google Scholar
    • Export Citation
  • 47.

    Shapira Y, , Yadid G, & Cotev A, et al: Protective effect of MK801 in experimental brain injury. J Neurotrauma 7:131139, 1991 Shapira Y, Yadid G, Cotev A, et al: Protective effect of MK801 in experimental brain injury. J Neurotrauma 7:131–139, 1991

    • Search Google Scholar
    • Export Citation
  • 48.

    Smith DH, , Casey K, & McIntosh TK: Pharmacologic therapy for traumatic brain injury: experimental approaches. New Hor 3:562572, 1995 Smith DH, Casey K, McIntosh TK: Pharmacologic therapy for traumatic brain injury: experimental approaches. New Hor 3:562–572, 1995

    • Search Google Scholar
    • Export Citation
  • 49.

    Stein SC, , Young GS, & Talucci RC, et al: Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery 30:160165, 1992 Stein SC, Young GS, Talucci RC, et al: Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery 30:160–165, 1992

    • Search Google Scholar
    • Export Citation
  • 50.

    Sutton RL, , Lescaudron L, & Stein DG: Unilateral cortical contusion injury in the rat: vascular disruption and temporal development of cortical necrosis. J Neurotrauma 10:135149, 1993 Sutton RL, Lescaudron L, Stein DG: Unilateral cortical contusion injury in the rat: vascular disruption and temporal development of cortical necrosis. J Neurotrauma 10:135–149, 1993

    • Search Google Scholar
    • Export Citation
  • 51.

    Takadera T, , Suzuki R, & Mohri T: Protection by ethanol of cortical neurons from N-methyl-D-aspartate-induced neurotoxicity is associated with blocking calcium influx. Brain Res 537:109114, 1990 Takadera T, Suzuki R, Mohri T: Protection by ethanol of cortical neurons from N-methyl-D-aspartate-induced neurotoxicity is associated with blocking calcium influx. Brain Res 537:109–114, 1990

    • Search Google Scholar
    • Export Citation
  • 52.

    Touho H, , Hirakawa K, & Hino A, et al: Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury. Neurosurgery 19:523531, 1986 Touho H, Hirakawa K, Hino A, et al: Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury. Neurosurgery 19:523–531, 1986

    • Search Google Scholar
    • Export Citation
  • 53.

    U.S. Department of Transportation, National Highway Traffic Safety Administration: Traffic Safety Facts 1993. Alcohol. Washington, D.C.: National Center for Statistics and Analysis, 1994 U.S. Department of Transportation, National Highway Traffic Safety Administration: Traffic Safety Facts 1993. Alcohol. Washington, D.C.: National Center for Statistics and Analysis, 1994

    • Search Google Scholar
    • Export Citation
  • 54.

    Vogel WH, , DeTurck K, & Miller JM: Differential effects of ethanol on plasma catecholamine levels in rats. Biochem Pharmacol 35:39833987, 1986 Vogel WH, DeTurck K, Miller JM: Differential effects of ethanol on plasma catecholamine levels in rats. Biochem Pharmacol 35:3983–3987, 1986

    • Search Google Scholar
    • Export Citation
  • 55.

    Waller PF, , Stewart JR, & Hansen AR, et al: The potentiating effects of alcohol on driver injury. JAMA 256:14611466, 1986 Waller PF, Stewart JR, Hansen AR, et al: The potentiating effects of alcohol on driver injury. JAMA 256:1461–1466, 1986

    • Search Google Scholar
    • Export Citation
  • 56.

    Ward RE, , Flynn TC, & Miller PW, et al: Effects of ethanol ingestion on the severity and outcome of trauma. Am J Surg 144:153157, 1982 Ward RE, Flynn TC, Miller PW, et al: Effects of ethanol ingestion on the severity and outcome of trauma. Am J Surg 144:153–157, 1982

    • Search Google Scholar
    • Export Citation
  • 57.

    Yamakami I, , Vink R, & Faden AI, et al: Effects of acute ethanol intoxication on experimental brain injury in the rat: neurobehavioral and phosphorus-31 nuclear magnetic resonance spectroscopy studies. J Neurosurg 82:813821, 1995 Yamakami I, Vink R, Faden AI, et al: Effects of acute ethanol intoxication on experimental brain injury in the rat: neurobehavioral and phosphorus-31 nuclear magnetic resonance spectroscopy studies. J Neurosurg 82:813–821, 1995

    • Search Google Scholar
    • Export Citation
  • 58.

    Zink BJ, & Feustel PJ: Effects of ethanol on respiratory function in traumatic brain injury. J Neurosurg 82:822828, 1995 Zink BJ, Feustel PJ: Effects of ethanol on respiratory function in traumatic brain injury. J Neurosurg 82:822–828, 1995

    • Search Google Scholar
    • Export Citation
  • 59.

    Zink BJ, , Walsh RF, & Feustel PJ: Effects of ethanol in traumatic brain injury. J Neurotrauma 10:275286, 1993 Zink BJ, Walsh RF, Feustel PJ: Effects of ethanol in traumatic brain injury. J Neurotrauma 10:275–286, 1993

    • Search Google Scholar
    • Export Citation

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