Many patients with an intracerebral hematoma deteriorate progressively after the hemorrhage because of the accumulation of edema fluid around the mass.13 The reason an intracerebral hematoma causes brain edema is unknown. The hematoma and its associated edema may combine to cause intracranial hypertension from progressive mass effect, producing brain shifts and secondary ischemia.
Better understanding of the pathophysiology of edema formation due to intracerebral hemorrhage might lead to improved clinical management of these patients. Our study sought to determine whether or not individual blood components cause edema formation or contribute to it through the coagulation cascade. If a substance in blood or a mechanism induced by blood clotting could be identified, blockade of the process might be possible.
This work was supported by Grants NS-17760 and NS-23870 from the National Institutes of Health.