Pharmacological and morphological effects of in vitro transluminal balloon angioplasty on normal and vasospastic canine basilar arteries

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  • 1 Department of Surgery, Division of Neurosurgery, Department of Pharmacology, Surgical Medical Research Institute, and Department of Radiology, University of Alberta, Edmonton, Alberta, Canada
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✓ Despite growing clinical use of transluminal balloon angioplasty (TBA) to treat cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH), the precise mechanism of action of balloon dilation on the cerebral arterial wall is unknown. In this experiment the authors examined the pharmacological and morphological changes in 10 normal and 12 vasospastic canine basilar arteries following in vitro silicone microballoon TBA. For the SAH group in which the double-hemorrhage model was used, vasospasm was confirmed by angiography and the animals were killed on Day 7 after the first SAH. In vitro TBA was performed on basilar arteries from normal and SAH dogs immediately after sacrifice and removal of the brain. The procedure was performed while the arteries were maintained in oxygenated Krebs buffer. In the pharmacological studies, potassium chloride, prostaglandin F, serotonin, and noradrenaline were used as vasoconstrictors, and bradykinin and calcium ionophore A23187 were used to produce an endothelium-dependent dilation. In both normal and vasospastic groups, the pharmacological responses of dilated segments of basilar arteries were compared to those of nondilated segments of the same arteries.

Vessels from all groups were examined using scanning electron microscopy (EM) and transmission EM. Scanning EM was used to study the intact vessel wall, the smooth-muscle cell layer obtained after digestion with hydrochloric acid, and the extracellular matrix obtained after digestion with bleach. Cross-sections of the vessel wall were examined using transmission EM.

The most striking finding was that immediately after in vitro TBA of both normal and vasospastic canine basilar arteries, there was a significant reduction (p < 0.05) of responses to both vasoconstrictors and vasorelaxants. As revealed by scanning EM and transmission EM, both normal and vasospastic vessels dilated with TBA showed flattening and patchy denudation of the endothelium, and straightening and occasional rupturing of the internal elastic lamina. In addition, vasospastic vessels dilated with TBA showed decreased surface rippling and mild stretching and straightening of smooth-muscle cells, and mild thinning of the tunica media. There was no gross vascular disruption or obvious change in the extracellular matrix of the vessel walls of either normal or vasospastic arteries after TBA. These results suggest that functional impairment of vasoreactivity in the vessel wall as a result of mechanical stretching of the smooth-muscle layer plays a more important role than structural alteration, at least in the immediate dilation produced in vasospastic arteries byTBA.

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Contributor Notes

Address reprint requests to: J. Max Findlay, M.D., Ph.D., Division of Neurosurgery, Department of Surgery, MacKenzie Health Sciences Center, 2D1.02, 8440 - 112 Street, Edmonton, Alberta, T6G 2B7 Canada.
  • 1.

    Barnwell SL, , Higashida RT, & Halbach VV: Transluminal angioplasty of intracerebral vessels for cerebral arterial spasm: reversal of neurological deficits after delayed treatment. Neurosurgery 25:424429, 1989 Barnwell SL, Higashida RT, Halbach VV: Transluminal angioplasty of intracerebral vessels for cerebral arterial spasm: reversal of neurological deficits after delayed treatment. Neurosurgery 25:424–429, 1989

    • Search Google Scholar
    • Export Citation
  • 2.

    Benashvili GM, , Bernanke DH, & Zubkov YN, et al: Angioplasty rearranges collagen after subarachnoid hemorrhage, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 341344 Benashvili GM, Bernanke DH, Zubkov YN, et al: Angioplasty rearranges collagen after subarachnoid hemorrhage, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 341–344

    • Search Google Scholar
    • Export Citation
  • 3.

    Block PC, , Baughman KL, & Pasternak RC, et al: Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model. Circulation 61:778785, 1980 Block PC, Baughman KL, Pasternak RC, et al: Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model. Circulation 61:778–785, 1980

    • Search Google Scholar
    • Export Citation
  • 4.

    Bracard S, , Picard L, & Marchal JC, et al: Role of angioplasty in the treatment of symptomatic vascular spasm occurring in the post-operative course of intracranial ruptured aneurysms. J Neuroradiol 17:619, 1990 Bracard S, Picard L, Marchal JC, et al: Role of angioplasty in the treatment of symptomatic vascular spasm occurring in the post-operative course of intracranial ruptured aneurysms. J Neuroradiol 17:6–19, 1990

    • Search Google Scholar
    • Export Citation
  • 5.

    Brothers MF, & Holgate RC: Intracranial angioplasty for treatment of vasospasm after subarachnoid hemorrhage: technique and modifications to improve branch access. AJNR 11:239247, 1990 Brothers MF, Holgate RC: Intracranial angioplasty for treatment of vasospasm after subarachnoid hemorrhage: technique and modifications to improve branch access. AJNR 11:239–247, 1990

    • Search Google Scholar
    • Export Citation
  • 6.

    Castaneda-Zuniga WR, , Laerum F, & Rysavy J, et al: Paralysis of arteries by intraluminal balloon dilatation. An experimental study. Radiology 14:7576, 1982 Castaneda-Zuniga WR, Laerum F, Rysavy J, et al: Paralysis of arteries by intraluminal balloon dilatation. An experimental study. Radiology 14:75–76, 1982

    • Search Google Scholar
    • Export Citation
  • 7.

    Chavez L, , Takahashi A, & Yoshimoto T, et al: Morphological changes in normal canine basilar arteries after transluminal angioplasty. Neurol Res 12:1216, 1990 Chavez L, Takahashi A, Yoshimoto T, et al: Morphological changes in normal canine basilar arteries after transluminal angioplasty. Neurol Res 12:12–16, 1990

    • Search Google Scholar
    • Export Citation
  • 8.

    Chesebro JH, , Lam JYT, & Badimon L, et al: Restenosis after arterial angioplasty: a hemorrheologic response to injury. Am J Cardiol 60:10B16B, 1987 Chesebro JH, Lam JYT, Badimon L, et al: Restenosis after arterial angioplasty: a hemorrheologic response to injury. Am J Cardiol 60:10B–16B, 1987

    • Search Google Scholar
    • Export Citation
  • 9.

    Clower BR, , Smith RR, & Haining JL, et al: Constrictive endarteropathy following experimental subarachnoid hemorrhage. Stroke 12:501508, 1981 Clower BR, Smith RR, Haining JL, et al: Constrictive endarteropathy following experimental subarachnoid hemorrhage. Stroke 12:501–508, 1981

    • Search Google Scholar
    • Export Citation
  • 10.

    Consigny PM, & LeVeen RF: Effects of angioplasty balloon inflation time on arterial contractions and mechanics. Invest Radiol 23:271276, 1988 Consigny PM, LeVeen RF: Effects of angioplasty balloon inflation time on arterial contractions and mechanics. Invest Radiol 23:271–276, 1988

    • Search Google Scholar
    • Export Citation
  • 11.

    Cox RH: Arterial wall mechanics and composition and the effects of smooth muscle activation. Am J Physiol 229:807812, 1975 Cox RH: Arterial wall mechanics and composition and the effects of smooth muscle activation. Am J Physiol 229:807–812, 1975

    • Search Google Scholar
    • Export Citation
  • 12.

    Coyne TJ, , Montanera WJ, & Macdonald RL: Transluminal angioplasty for cerebral vasospasm—The Toronto Hospital experience, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 333336 Coyne TJ, Montanera WJ, Macdonald RL: Transluminal angioplasty for cerebral vasospasm—The Toronto Hospital experience, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 333–336

    • Search Google Scholar
    • Export Citation
  • 13.

    Dinerman JL, , Lowenstein CJ, & Snyder SH: Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease. Circ Res 73:217222, 1993 Dinerman JL, Lowenstein CJ, Snyder SH: Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease. Circ Res 73:217–222, 1993

    • Search Google Scholar
    • Export Citation
  • 14.

    Dion JE, , Duckwiler GR, & Viñuela F, et al: Pre-operative microangioplasty of refractory vasospasm secondary to subarachnoid hemorrhage. Neuroradiology 32:232236, 1990 Dion JE, Duckwiler GR, Viñuela F, et al: Pre-operative microangioplasty of refractory vasospasm secondary to subarachnoid hemorrhage. Neuroradiology 32:232–236, 1990

    • Search Google Scholar
    • Export Citation
  • 15.

    Eskridge JM, , Newell DW, & Mayberg MR, et al: Update on transluminal angioplasty of vasospasm. Perspect Neurol Surg 1:120126, 1990 Eskridge JM, Newell DW, Mayberg MR, et al: Update on transluminal angioplasty of vasospasm. Perspect Neurol Surg 1:120–126, 1990

    • Search Google Scholar
    • Export Citation
  • 16.

    Findlay JM, , Macdonald RL, & Weir BK: Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovasc Brain Metab Rev 3:336361, 1991 Findlay JM, Macdonald RL, Weir BK: Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovasc Brain Metab Rev 3:336–361, 1991

    • Search Google Scholar
    • Export Citation
  • 17.

    Findlay JM, , Weir BKA, & Kanamaru K, et al: Arterial wall changes in cerebral vasospasm. Neurosurgery 25:736746, 1989 Findlay JM, Weir BKA, Kanamaru K, et al: Arterial wall changes in cerebral vasospasm. Neurosurgery 25:736–746, 1989

    • Search Google Scholar
    • Export Citation
  • 18.

    Gordon AM, , Huxley AF, & Julian JF: The variation in isometric tension with sarcomere length in vertebrate muscle fibres. J Physiol (Lond) 184:170192, 1966 Gordon AM, Huxley AF, Julian JF: The variation in isometric tension with sarcomere length in vertebrate muscle fibres. J Physiol (Lond) 184:170–192, 1966

    • Search Google Scholar
    • Export Citation
  • 19.

    Haley EC Jr, , Kassell NF, & Torner JC, et al: A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results. A report of the Cooperative Aneurysm Study. J Neurosurg 78:548553, 1993 Haley EC Jr, Kassell NF, Torner JC, et al: A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results. A report of the Cooperative Aneurysm Study. J Neurosurg 78:548–553, 1993

    • Search Google Scholar
    • Export Citation
  • 20.

    Herlihy JT, & Murphy RA: Length-tension relationship of smooth muscle of the hog carotid artery. Circ Res 33:275283, 1973 Herlihy JT, Murphy RA: Length-tension relationship of smooth muscle of the hog carotid artery. Circ Res 33:275–283, 1973

    • Search Google Scholar
    • Export Citation
  • 21.

    Higashida RT, , Halbach VV, & Cahan LD, et al: Transluminal angioplasty for treatment of intracranial arterial vasospasm. J Neurosurg 71:648653, 1989 Higashida RT, Halbach VV, Cahan LD, et al: Transluminal angioplasty for treatment of intracranial arterial vasospasm. J Neurosurg 71:648–653, 1989

    • Search Google Scholar
    • Export Citation
  • 22.

    Higashida RT, , Halbach VV, & Cahan LD, et al: Transluminal angioplasty for treatment of intracranial arterial vasospasm, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 421428 Higashida RT, Halbach VV, Cahan LD, et al: Transluminal angioplasty for treatment of intracranial arterial vasospasm, in Sano K, Takakura K, Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 421–428

    • Search Google Scholar
    • Export Citation
  • 23.

    Higashida RT, , Halbach VV, & Dowd CF, et al: Intravascular balloon dilatation therapy for intracranial arterial vasospasm: patient selection, technique, and clinical results. Neurosurg Rev 15:8995, 1992 Higashida RT, Halbach VV, Dowd CF, et al: Intravascular balloon dilatation therapy for intracranial arterial vasospasm: patient selection, technique, and clinical results. Neurosurg Rev 15:89–95, 1992

    • Search Google Scholar
    • Export Citation
  • 24.

    Higashida RT, , Hieshima GB, & Tsai FY, et al: Transluminal angioplasty of the cerebral and basilar artery. AJNR 8:745749, 1987 Higashida RT, Hieshima GB, Tsai FY, et al: Transluminal angioplasty of the cerebral and basilar artery. AJNR 8:745–749, 1987

    • Search Google Scholar
    • Export Citation
  • 25.

    Iwasa K, , Bernanke DH, & Smith RR, et al: Nonmuscle arterial constriction after subarachnoid hemorrhage: role of growth factors derived from platelets. Neurosurgery 32:619624, 1993 Iwasa K, Bernanke DH, Smith RR, et al: Nonmuscle arterial constriction after subarachnoid hemorrhage: role of growth factors derived from platelets. Neurosurgery 32:619–624, 1993

    • Search Google Scholar
    • Export Citation
  • 26.

    Kassell NF, , Helm G, & Simmons N, et al: Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg 77:848852, 1992 Kassell NF, Helm G, Simmons N, et al: Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg 77:848–852, 1992

    • Search Google Scholar
    • Export Citation
  • 27.

    Kataoka T, , Hyogo T, & Sasaki T, et al: Balloon angioplasty in the management of symptomatic vasospasm in patients with unclipped cerebral aneurysm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 337340 Kataoka T, Hyogo T, Sasaki T, et al: Balloon angioplasty in the management of symptomatic vasospasm in patients with unclipped cerebral aneurysm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 337–340

    • Search Google Scholar
    • Export Citation
  • 28.

    Knowles RG, & Moncada S: Nitric oxide as a signal in blood vessels. Trends Biochem Sci 17:399402, 1992 Knowles RG, Moncada S: Nitric oxide as a signal in blood vessels. Trends Biochem Sci 17:399–402, 1992

    • Search Google Scholar
    • Export Citation
  • 29.

    Kobayashi H, , Ide H, & Aradachi H, et al: Histological studies of intracranial vessels in primates following transluminal angioplasty for vasospasm. J Neurosurg 78:481486, 1993 Kobayashi H, Ide H, Aradachi H, et al: Histological studies of intracranial vessels in primates following transluminal angioplasty for vasospasm. J Neurosurg 78:481–486, 1993

    • Search Google Scholar
    • Export Citation
  • 30.

    Konishi Y, , Maemura E, & Shiota M, et al: Treatment of vasospasm by balloon angioplasty: experimental studies and clinical experiences. Neurol Res 14:273281, 1992 Konishi Y, Maemura E, Shiota M, et al: Treatment of vasospasm by balloon angioplasty: experimental studies and clinical experiences. Neurol Res 14:273–281, 1992

    • Search Google Scholar
    • Export Citation
  • 31.

    Konishi Y, , Maemura R, & Yokota H, et al: Treatment of cerebral vasospasm with dilatation balloon catheter: basic study of percutaneous transluminal angioplasty, in Wilkins RH (ed): Cerebral Vasospasm. New York: Raven Press, 1988, pp 509511 Konishi Y, Maemura R, Yokota H, et al: Treatment of cerebral vasospasm with dilatation balloon catheter: basic study of percutaneous transluminal angioplasty, in Wilkins RH (ed): Cerebral Vasospasm. New York: Raven Press, 1988, pp 509–511

    • Search Google Scholar
    • Export Citation
  • 32.

    Konishi Y, , Tokitsu M, & Sato E, et al: Percutaneous transluminal angioplasty (PTA) for vasospasm after subarachnoid hemorrhage, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 440442 Konishi Y, Tokitsu M, Sato E, et al: Percutaneous transluminal angioplasty (PTA) for vasospasm after Tokyo: University of Tokyo Press, 1990, pp 440–442

    • Search Google Scholar
    • Export Citation
  • 33.

    Le Roux PD, & Mayberg MR: Management of vasospasm: angioplasty, in Ratcheson RA, & Wirth FP (eds): Concepts in Neurosurgery. Ruptured Cerebral Aneurysms: Perioperative Management. Baltimore: Williams & Wilkins, 1994, Vol 6, pp 155167 Le Roux PD, Mayberg MR: Management of vasospasm: angioplasty, in Ratcheson RA, Wirth FP (eds): Concepts in Neurosurgery. Ruptured Cerebral Aneurysms: Perioperative Management. Baltimore: Williams & Wilkins, 1994, Vol 6, pp 155–167

    • Search Google Scholar
    • Export Citation
  • 34.

    Le Roux PD, , Newell DW, & Eskridge J, et al: Severe symptomatic vasospasm: the role of immediate postoperative angioplasty. J Neurosurg 80:224229, 1994 Le Roux PD, Newell DW, Eskridge J, et al: Severe symptomatic vasospasm: the role of immediate postoperative angioplasty. J Neurosurg 80:224–229, 1994

    • Search Google Scholar
    • Export Citation
  • 35.

    Linskey ME, , Horton JA, & Rao GR, et al: Fatal rupture of the intracranial carotid artery during transluminal angioplasty for vasospasm induced by subarachnoid hemorrhage. Case report. J Neurosurg 74:985990, 1991 Linskey ME, Horton JA, Rao GR, et al: Fatal rupture of the intracranial carotid artery during transluminal angioplasty for vasospasm induced by subarachnoid hemorrhage. Case report. J Neurosurg 74:985–990, 1991

    • Search Google Scholar
    • Export Citation
  • 36.

    Macdonald RL, , Weir BKA, & Chen MH, et al: Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Neurosurgery 29:544550, 1991 Macdonald RL, Weir BKA, Chen MH, et al: Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Neurosurgery 29:544–550, 1991

    • Search Google Scholar
    • Export Citation
  • 37.

    Macdonald RL, , Weir BKA, & Grace MGA, et al: Morphometric analysis of monkey cerebral arteries exposed in vivo to whole blood, oxyhemoglobin, methemoglobin, and bilirubin. Blood Vessels 28:498510, 1991 Macdonald RL, Weir BKA, Grace MGA, et al: Morphometric analysis of monkey cerebral arteries exposed in vivo to whole blood, oxyhemoglobin, methemoglobin, and bilirubin. Blood Vessels 28:498–510, 1991

    • Search Google Scholar
    • Export Citation
  • 38.

    Macdonald RL, , Weir BKA, & Young JD, et al: Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg 76:8190, 1992 Macdonald RL, Weir BKA, Young JD, et al: Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg 76:81–90, 1992

    • Search Google Scholar
    • Export Citation
  • 39.

    Mayberg M, , Eskridge J, & Newell D, et al: Angioplasty for symptomatic vasospasm, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 433436 Mayberg M, Eskridge J, Newell D, et al: Angioplasty for symptomatic vasospasm, in Sano K, Takakura K, Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 433–436

    • Search Google Scholar
    • Export Citation
  • 40.

    Mayberg M, , le Roux P, & Elliot P, et al: Treatment of cerebral vasospasm with transluminal angioplasty, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 329332 Mayberg M, le Roux P, Elliot P, et al: Treatment of cerebral vasospasm with transluminal angioplasty, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 329–332

    • Search Google Scholar
    • Export Citation
  • 41.

    Mayberg MR, , Okada T, & Bark DH: The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage. J Neurosurg 72:626633, 1990 Mayberg MR, Okada T, Bark DH: The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage. J Neurosurg 72:626–633, 1990

    • Search Google Scholar
    • Export Citation
  • 42.

    McBride W, , Lange RA, & Hillis LD: Restenosis after successful coronary angioplasty. Pathophysiology and prevention. N Engl J Med 318:17341737, 1988 McBride W, Lange RA, Hillis LD: Restenosis after successful coronary angioplasty. Pathophysiology and prevention. N Engl J Med 318:1734–1737, 1988

    • Search Google Scholar
    • Export Citation
  • 43.

    Miller RJ: Voltage-sensitive Ca2+ channels. J Biol Chem 267:14031406, 1992 Miller RJ: Voltage-sensitive Ca2+ channels. J Biol Chem 267:1403–1406, 1992

    • Search Google Scholar
    • Export Citation
  • 44.

    Moncada S, , Palmer RMJ, & Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109142, 1991 Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109–142, 1991

    • Search Google Scholar
    • Export Citation
  • 45.

    Nagasawa S, , Handa H, & Naruo Y, et al: Experimental cerebral vasospasm. Arterial wall mechanics and connective tissue composition. Stroke 13:595600, 1982 Nagasawa S, Handa H, Naruo Y, et al: Experimental cerebral vasospasm. Arterial wall mechanics and connective tissue composition. Stroke 13:595–600, 1982

    • Search Google Scholar
    • Export Citation
  • 46.

    Nemoto S, , Abe T, & Tanaka H: Percutaneous transluminal angioplasty for cerebral vasospasm following subarachnoid hemorrhage, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 437439 Nemoto S, Abe T, Tanaka H: Percutaneous transluminal angioplasty for cerebral vasospasm following subarachnoid hemorrhage, in Sano K, Takakura K, Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 437–439

    • Search Google Scholar
    • Export Citation
  • 47.

    Newell DW, , Eskridge JM, & Mayberg MR, et al: Angioplasty for the treatment of symptomatic vasospasm following subarachnoid hemorrhage. J Neurosurg 71:654660, 1989 Newell DW, Eskridge JM, Mayberg MR, et al: Angioplasty for the treatment of symptomatic vasospasm following subarachnoid hemorrhage. J Neurosurg 71:654–660, 1989

    • Search Google Scholar
    • Export Citation
  • 48.

    Newell DW, , Eskridge J, & Mayberg MR, et al: Endovascular treatment of intracranial aneurysms and cerebral vasospasm. Clin Neurosurg 39:348360, 1992 Newell DW, Eskridge J, Mayberg MR, et al: Endovascular treatment of intracranial aneurysms and cerebral vasospasm. Clin Neurosurg 39:348–360, 1992

    • Search Google Scholar
    • Export Citation
  • 49.

    Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607614, 1992 Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607–614, 1992

    • Search Google Scholar
    • Export Citation
  • 50.

    Pile-Spellman J, , Berenstein A, & Bun T, et al: Angioplasty of canine cerebral vessels. AJNR 8:938, 1987 (Abstract) Pile-Spellman J, Berenstein A, Bun T, et al: Angioplasty of canine cerebral vessels. AJNR 8:938, 1987 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 51.

    Price JM, , Davis DL, & Knauss EB: Length-dependent sensitivity in vascular smooth muscle. Am J Physiol 241:H557H563, 1981 Price JM, Davis DL, Knauss EB: Length-dependent sensitivity in vascular smooth muscle. Am J Physiol 241:H557–H563, 1981

    • Search Google Scholar
    • Export Citation
  • 52.

    Schweitzer DH, , Koek GH, & van der Laarse A: Spontaneous and pharmacologically-induced vasoconstrictive responses of rat aortic rings are attenuated by balloon angioplasty. Res Commun Chem Pathol Pharmacol 72:285294, 1991 Schweitzer DH, Koek GH, van der Laarse A: Spontaneous and pharmacologically-induced vasoconstrictive responses of rat aortic rings are attenuated by balloon angioplasty. Res Commun Chem Pathol Pharmacol 72:285–294, 1991

    • Search Google Scholar
    • Export Citation
  • 53.

    Smith RR: Nonsmooth muscle vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 297298 Smith RR: Nonsmooth muscle vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 297–298

    • Search Google Scholar
    • Export Citation
  • 54.

    Smith RR, , Connors JJI, & Yamamoto Y, et al: Balloon angioplasty for vasospasm: theoretical and practical considerations, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 415420 Smith RR, Connors JJI, Yamamoto Y, et al: Balloon angioplasty for vasospasm: theoretical and practical considerations, in Sano K, Takakura K, Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 415–420

    • Search Google Scholar
    • Export Citation
  • 55.

    Takahashi A, , Takahashi Y, & Mizoi K, et al: Transluminal balloon angioplasty for vasospasm after subarachnoid hemorrhage, in Sano K, , Takakura K, & Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 429432 Takahashi A, Takahashi Y, Mizoi K, et al: Transluminal balloon angioplasty for vasospasm after subarachnoid hemorrhage, in Sano K, Takakura K, Kassell NF, et al (eds): Cerebral Vasospasm. Tokyo: University of Tokyo Press, 1990, pp 429–432

    • Search Google Scholar
    • Export Citation
  • 56.

    Terada T, , Nakamura Y, & Yoshida N, et al: Percutaneous transluminal angioplasty for the M2 portion vasospasm following SAH: development of the new microballoon and report of cases. Surg Neurol 39:1317, 1993 Terada T, Nakamura Y, Yoshida N, et al: Percutaneous transluminal angioplasty for the M2 portion vasospasm following SAH: development of the new microballoon and report of cases. Surg Neurol 39:13–17, 1993

    • Search Google Scholar
    • Export Citation
  • 57.

    Terai Y, , Smith RR, & Bernanke DH, et al: Immunohistochemical identification of non-muscle components in human cerebral vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 289292 Terai Y, Smith RR, Bernanke DH, et al: Immunohistochemical identification of non-muscle components in human cerebral vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 289–292

    • Search Google Scholar
    • Export Citation
  • 58.

    Varsos VG, , Liszczak TM, & Han KH, et al: Delayed cerebral vasopasm is not reversible by aminophylline, nifedipine, or papaverine in a “two-hemorrhage” canine model. J Neurosurg 58:1117, 1983 Varsos VG, Liszczak TM, Han KH, et al: Delayed cerebral vasopasm is not reversible by aminophylline, nifedipine, or papaverine in a “two-hemorrhage” canine model. J Neurosurg 58:11–17, 1983

    • Search Google Scholar
    • Export Citation
  • 59.

    Vollrath B, , Weir BKA, & Macdonald RL, et al: Intracellular mechanisms involved in the responses of cerebrovascular smooth-muscle cells to hemoglobin. J Neurosurg 80:261268, 1994 Vollrath B, Weir BKA, Macdonald RL, et al: Intracellular mechanisms involved in the responses of cerebrovascular smooth-muscle cells to hemoglobin. J Neurosurg 80:261–268, 1994

    • Search Google Scholar
    • Export Citation
  • 60.

    Walker-Caprioglio HM, , Trotter JA, & Mercure J, et al: Organization of rat mesenteric artery after removal of cells or extracellular matrix components. Cell Tissue Res 264:6377, 1991 Walker-Caprioglio HM, Trotter JA, Mercure J, et al: Organization of rat mesenteric artery after removal of cells or extracellular matrix components. Cell Tissue Res 264:63–77, 1991

    • Search Google Scholar
    • Export Citation
  • 61.

    Walsh MP: Calcium-dependent mechanisms of regulation of smooth muscle contraction. Biochem Cell Biol 69:771799, 1991 Walsh MP: Calcium-dependent mechanisms of regulation of smooth muscle contraction. Biochem Cell Biol 69:771–799, 1991

    • Search Google Scholar
    • Export Citation
  • 62.

    Wolf GL, & Lentini EA: The influence of short-duration stretch on vasoconstrictor response in rabbit aortas. Invest Radiol 19:269272, 1984 Wolf GL, Lentini EA: The influence of short-duration stretch on vasoconstrictor response in rabbit aortas. Invest Radiol 19:269–272, 1984

    • Search Google Scholar
    • Export Citation
  • 63.

    Wolf GL, , Lentini EA, & Le Veen RF: Reduced vasoconstrictor response after angioplasty in normal rabbit aortas. AJR 142:10231025, 1984 Wolf GL, Lentini EA, Le Veen RF: Reduced vasoconstrictor response after angioplasty in normal rabbit aortas. AJR 142:1023–1025, 1984

    • Search Google Scholar
    • Export Citation
  • 64.

    Yamamoto Y, , Bernanke DH, & Smith RR: Accelerated non-muscle contraction after subarachnoid hemorrhage: cerebrospinal fluid testing in a culture model. Neurosurgery 27:921928, 1990 Yamamoto Y, Bernanke DH, Smith RR: Accelerated non-muscle contraction after subarachnoid hemorrhage: cerebrospinal fluid testing in a culture model. Neurosurgery 27:921–928, 1990

    • Search Google Scholar
    • Export Citation
  • 65.

    Yamamoto Y, , Smith RR, & Bernanke DH: Accelerated nonmuscle contraction after subarachnoid hemorrhage: culture and characterization of myofibroblasts from human cerebral arteries in vasospasm. Neurosurgery 30:337345, 1992 Yamamoto Y, Smith RR, Bernanke DH: Accelerated nonmuscle contraction after subarachnoid hemorrhage: culture and characterization of myofibroblasts from human cerebral arteries in vasospasm. Neurosurgery 30:337–345, 1992

    • Search Google Scholar
    • Export Citation
  • 66.

    Yamamoto Y, , Smith RR, & Bernanke DH: Mechanism of action of balloon angioplasty in cerebral vasospasm. Neurosurgery 30:16, 1992 Yamamoto Y, Smith RR, Bernanke DH: Mechanism of action of balloon angioplasty in cerebral vasospasm. Neurosurgery 30:1–6, 1992

    • Search Google Scholar
    • Export Citation
  • 67.

    Zollikofer CL, , Chain J, & Salomonowitz E, et al: Percutaneous transluminal angioplasty of the aorta. Light and electron microscopic observations in normal and atherosclerotic rabbits. Radiology 151:355363, 1984 Zollikofer CL, Chain J, Salomonowitz E, et al: Percutaneous transluminal angioplasty of the aorta. Light and electron microscopic observations in normal and atherosclerotic rabbits. Radiology 151:355–363, 1984

    • Search Google Scholar
    • Export Citation
  • 68.

    Zubkov YN, , Semenutin V, & Benashvili G: Cerebral blood flow following angioplasty for vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 325327 Zubkov YN, Semenutin V, Benashvili G: Cerebral blood flow following angioplasty for vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 325–327

    • Search Google Scholar
    • Export Citation
  • 69.

    Zubkov Y, , Alexander LF, & Benashvili GM, et al: Cerebral angioplasty for vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 321324 Zubkov Y, Alexander LF, Benashvili GM, et al: Cerebral angioplasty for vasospasm, in Findlay JM (ed): Cerebral Vasospasm. Proceedings of the Vth International Conference on Cerebral Vasospasm. Amsterdam: Elsevier, 1993, pp 321–324

    • Search Google Scholar
    • Export Citation
  • 70.

    Zubkov YN, , Nikiforov BM, & Shustin VA: Balloon catheter technique of dilatation of constricted cerebral arteries after aneurysmal SAH. Acta Neurochir 70:6579, 1984 Zubkov YN, Nikiforov BM, Shustin VA: Balloon catheter technique of dilatation of constricted cerebral arteries after aneurysmal SAH. Acta Neurochir 70:65–79, 1984

    • Search Google Scholar
    • Export Citation

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