This report describes a case of gigantism in a young child with an extensive optic pathway glioma. To our knowledge, this is the first case report to document tumor infiltration of somatostatinergic pathways using immunocytochemical methods. Additional immunocytochemical studies support the argument that gigantism in this patient resulted from disordered regulation of GH secretion, rather than a functionally active GRH-secreting tumor. Moreover, it was demonstrated that areas showing hyperintense signal abnormalities on T2-weighted magnetic resonance (MR) imaging do not necessarily indicate the presence of tumor invasion in diffuse optic pathway glioma.
The authors thank Kalman T. Kovacs, M.D., Ph.D., and E. Horvath, Ph.D., for performing the immunocytochemical studies and for their helpful discussions.