Noncommunicating syringomyelia following occlusion of central canal in rats

Experimental model and histological findings

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  • 1 Departments of Neurosurgery and Pathology, State University of New York, Health Science Center at Brooklyn, and the Kings County Hospital Center, Brooklyn, New York
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✓ This report describes a new and reliable technique for producing experimental noncommunicating syringomyelia. In 30 rats, 1.2 to 1.6 µl of kaolin was microinjected into the dorsal columns and central gray matter of the spinal cord at C-6. The inoculations caused transient neurological deficits in four animals and no deficits in 26 animals. Within 24 hours, kaolin and polymorphonuclear leukocytes entered the central canal and drained rostrally. The clearance of inflammatory products induced a proliferation of ependymal cells and periependymal fibrous astrocytes, which formed synechiae and obstructed the canal at the level of injection and at one or more levels up to C-1. In 22 animals followed for 48 hours or longer, the upper end of the central canal became acutely dilated and formed an ependyma-lined syrinx that enlarged to massive dimensions within 6 weeks. The rostral syrinxes did not communicate with the fourth ventricle and were not associated with hydrocephalus.

The histological findings in acute noncommunicating syringomyelia were characterized by progressive stretching and thinning of the ependyma, elongation of intracanalicular septae, and the formation of periependymal edema. After 3 weeks, there was progressive compression of the periependymal tissues associated with stretching of axons, fragmentation of myelin sheaths, and the formation of myelin droplets. These findings and the sequence in which they evolved were identical in most respects to those occurring in acute and subacute noncommunicating hydrocephalus.

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  • 1.

    Aboulker J: La syringomyélic et les liquides intra-rachidiens. Neurochirurgie 25 (Suppl 1):1144, 1979 Aboulker J: La syringomyélic et les liquides intra-rachidiens. Neurochirurgie 25 (Suppl 1):1–144, 1979

    • Search Google Scholar
    • Export Citation
  • 2.

    Ball MJ, & Dayan AD: Pathogenesis of syringomyelia. Lancet 2:799801, 1972 Ball MJ, Dayan AD: Pathogenesis of syringomyelia. Lancet 2:799–801, 1972

    • Search Google Scholar
    • Export Citation
  • 3.

    Barnett HJM, , Botterell EH, & Jousse AT, et al: Progressive myelopathy as a sequel to traumatic paraplegia. Brain 89:159174, 1966 Barnett HJM, Botterell EH, Jousse AT, et al: Progressive myelopathy as a sequel to traumatic paraplegia. Brain 89:159–174, 1966

    • Search Google Scholar
    • Export Citation
  • 4.

    Barnett HJM, , Foster JB, & Hudgson D: Syringomyelia. London: WB Saunders, 1973, 318 pp Barnett HJM, Foster JB, Hudgson D: Syringomyelia. London: WB Saunders, 1973, 318 pp

    • Search Google Scholar
    • Export Citation
  • 5.

    Becker DP, , Wilson JA, & Watson GW: The spinal cord central canal: response to experimental hydrocephalus and canal occlusion. J Neurosurg 36:416424, 1972 Becker DP, Wilson JA, Watson GW: The spinal cord central canal: response to experimental hydrocephalus and canal occlusion. J Neurosurg 36:416–424, 1972

    • Search Google Scholar
    • Export Citation
  • 6.

    Clark RG, , McGrath PP, & Milhorat TH, et al: Ultrastructural white matter changes in acute experimental hydrocephalus in the rhesus monkey. Proc Electron Micro Soc Am 27:344345, 1969 Clark RG, McGrath PP, Milhorat TH, et al: Ultrastructural white matter changes in acute experimental hydrocephalus in the rhesus monkey. Proc Electron Micro Soc Am 27:344–345, 1969

    • Search Google Scholar
    • Export Citation
  • 7.

    Clark RG, & Milhorat TH: Experimental hydrocephalus. Part 3: Light microscopic findings in acute and subacute obstructive hydrocephalus in the monkey. J Neurosurg 32:400413, 1970 Clark RG, Milhorat TH: Experimental hydrocephalus. Part 3: Light microscopic findings in acute and subacute obstructive hydrocephalus in the monkey. J Neurosurg 32:400–413, 1970

    • Search Google Scholar
    • Export Citation
  • 8.

    Eisenberg HM, , McLennan JE, & Welch K: Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41:2028, 1974 Eisenberg HM, McLennan JE, Welch K: Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41:20–28, 1974

    • Search Google Scholar
    • Export Citation
  • 9.

    Enzmann DR: Imaging of syringomyelia, in Batzdorf U (ed): Syringomyelia: Current Concepts in Diagnosis and Treatment. Baltimore: Williams & Wilkins, 1991, pp 116139 Enzmann DR: Imaging of syringomyelia, in Batzdorf U (ed): Syringomyelia: Current Concepts in Diagnosis and Treatment. Baltimore: Williams & Wilkins, 1991, pp 116–139

    • Search Google Scholar
    • Export Citation
  • 10.

    Enzmann DR, , O'Donohue J, & Rubin JB, et al: CSF perfusions within nonneoplastic spinal cord cysts. AJR 149:149157, 1987 Enzmann DR, O'Donohue J, Rubin JB, et al: CSF perfusions within nonneoplastic spinal cord cysts. AJR 149:149–157, 1987

    • Search Google Scholar
    • Export Citation
  • 11.

    Freeman LW: Ascending spinal paralysis. Case presentation. J Neurosurg 16:120122, 1959 Freeman LW: Ascending spinal paralysis. Case presentation. J Neurosurg 16:120–122, 1959

    • Search Google Scholar
    • Export Citation
  • 12.

    Gardner WJ, & Goodall RJ: The surgical treatment of Arnold-Chiari malformation in adults. An explanation of its mechanism and importance of encephalography in diagnosis. J Neurosurg 7:199206, 1950 Gardner WJ, Goodall RJ: The surgical treatment of Arnold-Chiari malformation in adults. An explanation of its mechanism and importance of encephalography in diagnosis. J Neurosurg 7:199–206, 1950

    • Search Google Scholar
    • Export Citation
  • 13.

    Hochwald GM, , Boal RD, & Marlin AE, et al: Changes in regional blood-flow and water content of brain and spinal cord in acute and chronic experimental hydrocephalus. Dev Med Child Neurol Suppl 35:4250, 1975 Hochwald GM, Boal RD, Marlin AE, et al: Changes in regional blood-flow and water content of brain and spinal cord in acute and chronic experimental hydrocephalus. Dev Med Child Neurol Suppl 35:42–50, 1975

    • Search Google Scholar
    • Export Citation
  • 14.

    Lee BC, , Zimmerman RD, & Manning JJ, et al: MR imaging of syringomyelia and hydromyelia. AJR 144:11491156, 1985 Lee BC, Zimmerman RD, Manning JJ, et al: MR imaging of syringomyelia and hydromyelia. AJR 144:1149–1156, 1985

    • Search Google Scholar
    • Export Citation
  • 15.

    McGrath PP, , Clark RG, & Milhorat TH, et al: Ultrastructural changes in the ependyma of the septum pellucidum in acute experimental hydrocephalus in the rhesus monkey. Proc Electron Micro Soc Am 27:346347, 1969 McGrath PP, Clark RG, Milhorat TH, et al: Ultrastructural changes in the ependyma of the septum pellucidum in acute experimental hydrocephalus in the rhesus monkey. Proc Electron Micro Soc Am 27:346–347, 1969

    • Search Google Scholar
    • Export Citation
  • 16.

    Milhorat TH: Experimental hydrocephalus. Part I: A technique for producing obstructive hydrocephalus in the monkey. J Neurosurg 32:385389, 1970 Milhorat TH: Experimental hydrocephalus. Part I: A technique for producing obstructive hydrocephalus in the monkey. J Neurosurg 32:385–389, 1970

    • Search Google Scholar
    • Export Citation
  • 17.

    Milhorat TH: Hydrocephalus and the Cerebrospinal Fluid. Baltimore: Williams & Wilkins, 1972, pp 66128 Milhorat TH: Hydrocephalus and the Cerebrospinal Fluid. Baltimore: Williams & Wilkins, 1972, pp 66–128

    • Search Google Scholar
    • Export Citation
  • 18.

    Milhorat TH, , Adler DE, & Heger IM, et al: Histopathology of experimental hematomyelia. J Neurosurg 75:911915, 1991 Milhorat TH, Adler DE, Heger IM, et al: Histopathology of experimental hematomyelia. J Neurosurg 75:911–915, 1991

    • Search Google Scholar
    • Export Citation
  • 19.

    Milhorat TH, , Clark RG, & Hammock MK, et al: Structural, ultrastructural, and permeability changes in the ependyma and surrounding brain favoring equilibration in progressive hydrocephalus. Arch Neurol 22:397407, 1970 Milhorat TH, Clark RG, Hammock MK, et al: Structural, ultrastructural, and permeability changes in the ependyma and surrounding brain favoring equilibration in progressive hydrocephalus. Arch Neurol 22:397–407, 1970

    • Search Google Scholar
    • Export Citation
  • 20.

    Milhorat TH, , Johnson RW, & Johnson WD: Evidence of CSF flow in rostral direction through the central canal in rats, in Matsumoto S, & Tamaki N (eds): Hydrocephalus. Pathogenesis and Treatment. Tokyo: Springer-Verlag, 1992, pp 207217 Milhorat TH, Johnson RW, Johnson WD: Evidence of CSF flow in rostral direction through the central canal in rats, in Matsumoto S, Tamaki N (eds): Hydrocephalus. Pathogenesis and Treatment. Tokyo: Springer-Verlag, 1992, pp 207–217

    • Search Google Scholar
    • Export Citation
  • 21.

    Milhorat TH, , Johnson WD, & Miller JI, et al: Surgical treatment of syringomyelia based on magnetic resonance imaging criteria. Neurosurgery 31:231245, 1992 Milhorat TH, Johnson WD, Miller JI, et al: Surgical treatment of syringomyelia based on magnetic resonance imaging criteria. Neurosurgery 31:231–245, 1992

    • Search Google Scholar
    • Export Citation
  • 22.

    Milhorat TH, , Nakamura S, & Heger I, et al: Ultrastructural evidence of sink function of central canal of spinal cord as demonstrated by clearance of horseradish peroxidase. Proc Electron Micro Soc Am 50:700701, 1992 Milhorat TH, Nakamura S, Heger I, et al: Ultrastructural evidence of sink function of central canal of spinal cord as demonstrated by clearance of horseradish peroxidase. Proc Electron Micro Soc Am 50:700–701, 1992

    • Search Google Scholar
    • Export Citation
  • 23.

    Park TS, , Cail WS, & Broaddus WC, et al: Lumboperitoneal shunt combined with myelotomy for treatment of syringohydromyelia. J Neurosurg 70:721727, 1989 Park TS, Cail WS, Broaddus WC, et al: Lumboperitoneal shunt combined with myelotomy for treatment of syringohydromyelia. J Neurosurg 70:721–727, 1989

    • Search Google Scholar
    • Export Citation
  • 24.

    Quencer RM, , et Gammal T, & Cohen G: Syringomyelia associated with intradural masses of the spinal cord. AJNR 7:143148, 1986 Quencer RM, et Gammal T, Cohen G: Syringomyelia associated with intradural masses of the spinal cord. AJNR 7:143–148, 1986

    • Search Google Scholar
    • Export Citation
  • 25.

    Samuelsson L, , Bergström K, & Thomas KA, et al: MR imaging of syringohydromyelia and Chiari malformations in myelomeningocele patients with scoliosis. AJNR 8:539546, 1987 Samuelsson L, Bergström K, Thomas KA, et al: MR imaging of syringohydromyelia and Chiari malformations in myelomeningocele patients with scoliosis. AJNR 8:539–546, 1987

    • Search Google Scholar
    • Export Citation
  • 26.

    Sherman JL, , Barkovich AJ, & Citrin CM: The MR appearance of syringomvelia: new observations. AJR 148:381391, 1986 Sherman JL, Barkovich AJ, Citrin CM: The MR appearance of syringomvelia: new observations. AJR 148:381–391, 1986

    • Search Google Scholar
    • Export Citation
  • 27.

    Williams B: Pathogenesis of syringomyelia, in Batzdorf U (ed): Syringomyelia: Current Concepts in Diagnosis and Treatment. Baltimore: Williams & Wilkins, 1991, pp 5990 Williams B: Pathogenesis of syringomyelia, in Batzdorf U (ed): Syringomyelia: Current Concepts in Diagnosis and Treatment. Baltimore: Williams & Wilkins, 1991, pp 59–90

    • Search Google Scholar
    • Export Citation
  • 28.

    Williams B, & Bentley J: Experimental communicating syringomyelia in dogs after cisternal kaolin injection. Part 1. Morphology. J Neurol Sci 48:93107, 1980 Williams B, Bentley J: Experimental communicating syringomyelia in dogs after cisternal kaolin injection. Part 1. Morphology. J Neurol Sci 48:93–107, 1980

    • Search Google Scholar
    • Export Citation

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