Changes of neuropeptide immunoreactivity in cerebrovascular nerve fibers after experimentally produced SAH

Immunohistochemical study in the dog

Yoshihiko Uemura M.D.1, Tetsuo Sugimoto M.D., Ph.D.1, Shinichiro Okamoto M.D., Ph.D.1, Hajime Handa M.D., Ph.D.1, and Noboru Mizuno M.D., Ph.D.1
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  • 1 Departments of Anatomy (1st Division) and Neurosurgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
Page Range:
741–747
Volume/Issue:
Volume 66: Issue 5
DOI link:
https://doi.org/10.3171/jns.1987.66.5.0741
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✓ The immunoreactivity of vasoactive intestinal polypeptide (VIP)-, substance P (SP)-, and neuropeptide Y (NPY)-containing nerve fibers in the basilar artery (BA) and proximal portion of the middle cerebral artery (M1) was immunohistochemically examined in the dog after experimentally produced subarachnoid hemorrhage (SAH). The SAH was produced by a single injection of fresh autologous arterial blood (1 ml/kg body weight) into the cisterna magna. The density (the averaged number of nerve fibers in a unit area) of VIP-, SP-, and NPY-immunoreactive perivascular nerve fibers in the M1 segment and the BA was markedly decreased (5% to 40% of the normal value) immediately after the injection. The density of VIP- and SP-immunoreactive perivascular fibers increased 2 or 3 weeks after SAH and became normal by the 63rd day after injection. On the other hand, no substantial recovery was observed in the density of NPY-immunoreactive perivascular fibers by 63 days after injection.

Volume 66: Issue 5 (May 1987)

in Journal of Neurosurgery
Cover Journal of Neurosurgery

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