The surgical treatment of childhood moyamoya disease

Meredith V. Olds M.D.1, Robert W. Griebel M.D., F.R.C.S.(C)1, Harold J. Hoffman M.D., F.R.C.S.(C)1, Marilyn Craven M.D., Ph.D.1, Sylvester Chuang M.D., F.R.C.P.1, and Hart Schutz M.D., F.R.C.S.(C)1
View More View Less
  • 1 Divisions of Neurosurgery and Neuroradiology, University of Toronto, Hospital for Sick Children, and Toronto Western Hospital, Toronto, Ontario, Canada
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00
Print or Print + Online

✓Moyamoya disease is a progressive disorder, predominantly seen in childhood, that can cause severe permanent disability. The search for effective treatment has largely been unsuccessful in the past, but recent efforts at surgical intervention have shown promising results.

The natural history of moyamoya disease, the options for treatment, and a series of patients from the Hospital for Sick Children in Toronto are reviewed. The results of surgical treatment are encouraging and the authors believe that it should be offered to all pediatric patients in the progressive stage of the disease.

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $505.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $600.00

Contributor Notes

Address reprint requests to: Harold J. Hoffman, M.D., F.R.C.S.(C), Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
  • 1.

    Amine ARC, , Moody RA, & Meeks W: Bilateral temporal-middle cerebral artery anastomosis for moyamoya syndrome. Surg Neurol 8:36, 1977 Amine ARC, Moody RA, Meeks W: Bilateral temporal-middle cerebral artery anastomosis for moyamoya syndrome. Surg Neurol 8:3–6, 1977

    • Search Google Scholar
    • Export Citation
  • 2.

    Boone SC, & Sampson DS: Observations on moyamoya disease: a case treated with superficial temporal-middle cerebral artery anastomosis. Surg Neurol 9:189193, 1978 Boone SC, Sampson DS: Observations on moyamoya disease: a case treated with superficial temporal-middle cerebral artery anastomosis. Surg Neurol 9:189–193, 1978

    • Search Google Scholar
    • Export Citation
  • 3.

    Carlson CB, , Harvey FH, & Loop J: Progressive alternating hemiplegia in early childhood with basal arterial stenosis and telangiectasia (moyamoya syndrome). Neurology 23:734744, 1973 Carlson CB, Harvey FH, Loop J: Progressive alternating hemiplegia in early childhood with basal arterial stenosis and telangiectasia (moyamoya syndrome). Neurology 23:734–744, 1973

    • Search Google Scholar
    • Export Citation
  • 4.

    Coakham HB, , Duchen LW, & Scaravilli F: Moya-moya disease: clinical and pathological report of a case with associated myopathy. J Neurol Neurosurg Psychiatry 42:289297, 1979 Coakham HB, Duchen LW, Scaravilli F: Moya-moya disease: clinical and pathological report of a case with associated myopathy. J Neurol Neurosurg Psychiatry 42:289–297, 1979

    • Search Google Scholar
    • Export Citation
  • 5.

    Cohen N, , Berant M, & Simon J: Moyamoya and Fanconi's anemia. Pediatrics 65:804805, 1980 Cohen N, Berant M, Simon J: Moyamoya and Fanconi's anemia. Pediatrics 65:804–805, 1980

    • Search Google Scholar
    • Export Citation
  • 6.

    Crosley CJ: Childhood moyamoya presenting as subarachnoid hemorrhage. Arch Neurol 36:5859, 1979 (Letter) Crosley CJ: Childhood moyamoya presenting as subarachnoid hemorrhage. Arch Neurol 36:58–59, 1979 (Letter)

    • Search Google Scholar
    • Export Citation
  • 7.

    Halonen H, , Halonen V, & Donner M, et al. : Occlusive disease of intracranial main arteries with collateral networks in children. Neuropaediatrie 4:187206, 1973 Halonen H, Halonen V, Donner M, et al: Occlusive disease of intracranial main arteries with collateral networks in children. Neuropaediatrie 4:187–206, 1973

    • Search Google Scholar
    • Export Citation
  • 8.

    Handa J, & Handa H: Progressive cerebral arterial occlusive disease: analysis of 27 cases. Neuroradiology 3:119133, 1972 Handa J, Handa H: Progressive cerebral arterial occlusive disease: analysis of 27 cases. Neuroradiology 3:119–133, 1972

    • Search Google Scholar
    • Export Citation
  • 9.

    Harwood-Nash DC, , McDonald P, & Argent W: Cerebral arterial disease in children. An angiographic study of 40 cases. AJR 111:672686, 1971 Harwood-Nash DC, McDonald P, Argent W: Cerebral arterial disease in children. An angiographic study of 40 cases. AJR 111:672–686, 1971

    • Search Google Scholar
    • Export Citation
  • 10.

    Hilal SK, , Solomon GE, & Gold AP, et al. : Primary cerebral arterial occlusive disease in children. Part I: Acute acquired hemiplegia. Radiology 99:7186, 93–94, 1971 Hilal SK, Solomon GE, Gold AP, et al: Primary cerebral arterial occlusive disease in children. Part I: Acute acquired hemiplegia. Radiology 99:71–86, 93–94, 1971

    • Search Google Scholar
    • Export Citation
  • 11.

    Hilal SK, , Solomon GE, & Gold AP, et al. : Primary cerebral arterial occlusive disease in children. Part II: Neurocutaneous syndromes. Radiology 99:8794, 1971 Hilal SK, Solomon GE, Gold AP, et al: Primary cerebral arterial occlusive disease in children. Part II: Neurocutaneous syndromes. Radiology 99:87–94, 1971

    • Search Google Scholar
    • Export Citation
  • 12.

    Karasawa J, , Kikuchi H, & Furuse S, et al. : Treatment of moyamoya disease with STA-MCA anastomosis. J Neurosurg 49:679688, 1978 Karasawa J, Kikuchi H, Furuse S, et al: Treatment of moyamoya disease with STA-MCA anastomosis. J Neurosurg 49:679–688, 1978

    • Search Google Scholar
    • Export Citation
  • 13.

    Kitahara T, , Ariga N, & Yamaura A, et al. : Familial occurrence of moya-moya disease: report of three Japanese families. J Neurol Neurosurg Psychiatry 42:208214, 1979 Kitahara T, Ariga N, Yamaura A, et al: Familial occurrence of moya-moya disease: report of three Japanese families. J Neurol Neurosurg Psychiatry 42:208–214, 1979

    • Search Google Scholar
    • Export Citation
  • 14.

    Kitahara T, , Okumura K, & Semba A, et al. : Genetic and immunologic analysis on moya-moya. J Neurol Neurosurg Psychiatry 45:10481052, 1982 Kitahara T, Okumura K, Semba A, et al: Genetic and immunologic analysis on moya-moya. J Neurol Neurosurg Psychiatry 45:1048–1052, 1982

    • Search Google Scholar
    • Export Citation
  • 15.

    Krayenbühl HA: The moyamoya syndrome and the neurosurgeon. Surg Neurol 4:353360, 1975 Krayenbühl HA: The moyamoya syndrome and the neurosurgeon. Surg Neurol 4:353–360, 1975

    • Search Google Scholar
    • Export Citation
  • 16.

    Kudo T: Spontaneous occlusion of the circle of Willis. A disease apparently confined to Japanese. Neurology 18:485496, 1968 Kudo T: Spontaneous occlusion of the circle of Willis. A disease apparently confined to Japanese. Neurology 18:485–496, 1968

    • Search Google Scholar
    • Export Citation
  • 17.

    Leeds NE, & Abbott KH: Collateral circulation in cerebro-vascular disease in childhood via rete mirabile and perforating branches of anterior choroidal and posterior cerebral arteries. Radiology 85:628634, 1965 Leeds NE, Abbott KH: Collateral circulation in cerebro-vascular disease in childhood via rete mirabile and perforating branches of anterior choroidal and posterior cerebral arteries. Radiology 85:628–634, 1965

    • Search Google Scholar
    • Export Citation
  • 18.

    Maki Y, , Nakada Y, & Nose T, et al. : Clinical and radioisotopic follow-up study of “moyamoya.” Childs Brain 2:257271, 1976 Maki Y, Nakada Y, Nose T, et al: Clinical and radioisotopic follow-up study of “moyamoya.” Childs Brain 2:257–271, 1976

    • Search Google Scholar
    • Export Citation
  • 19.

    Matsushima Y, , Fukai N, & Tanaka K, et al. : A new surgical treatment of moyamoya disease in children: a preliminary report. Surg Neurol 15:313320, 1981 Matsushima Y, Fukai N, Tanaka K, et al: A new surgical treatment of moyamoya disease in children: a preliminary report. Surg Neurol 15:313–320, 1981

    • Search Google Scholar
    • Export Citation
  • 20.

    Matsushima Y, & Inaba Y: Moyamoya disease in children and its surgical treatment. Introduction of a new surgical procedure and its follow-up angiograms. Childs Brain 11:155170, 1984 Matsushima Y, Inaba Y: Moyamoya disease in children and its surgical treatment. Introduction of a new surgical procedure and its follow-up angiograms. Childs Brain 11:155–170, 1984

    • Search Google Scholar
    • Export Citation
  • 21.

    Nishimoto A, & Takeuchi S: Moyamoya disease. Abnormal cerebrovascular network in the cerebral basal region, in Vinken PJ, & Bruyn GW (eds): Vascular Diseases of the Nervous System, Part II. Handbook of Clinical Neurology. Vol 12. Amsterdam: North-Holland, 1972, pp 352383 Nishimoto A, Takeuchi S: Moyamoya disease. Abnormal cerebrovascular network in the cerebral basal region, in Vinken PJ, Bruyn GW (eds): Vascular Diseases of the Nervous System, Part II. Handbook of Clinical Neurology. Vol 12. Amsterdam: North-Holland, 1972, pp 352–383

    • Search Google Scholar
    • Export Citation
  • 22.

    Pearson E, , Lenn NJ, & Cail WS: Moyamoya and other causes of stroke in patients with Down syndrome. Pediatr Neurol 1:174179, 1985 Pearson E, Lenn NJ, Cail WS: Moyamoya and other causes of stroke in patients with Down syndrome. Pediatr Neurol 1:174–179, 1985

    • Search Google Scholar
    • Export Citation
  • 23.

    Rajakulasingam K, , Cerullo LJ, & Raimondi AJ: Childhood moyamoya syndrome. Postradiation pathogenesis. Childs Brain 5:467475, 1979 Rajakulasingam K, Cerullo LJ, Raimondi AJ: Childhood moyamoya syndrome. Postradiation pathogenesis. Childs Brain 5:467–475, 1979

    • Search Google Scholar
    • Export Citation
  • 24.

    Schoenberg BS, , Mellinger JF, & Schoenberg DG: Moyamoya disease in children. South Med J 71:237241, 1978 Schoenberg BS, Mellinger JF, Schoenberg DG: Moyamoya disease in children. South Med J 71:237–241, 1978

    • Search Google Scholar
    • Export Citation
  • 25.

    Schoenberg BS, , Mellinger JF, & Schoenberg DG, et al. : Moyamoya disease presenting as a seizure disorder. A case report. Arch Neurol 34:511512, 1977 Schoenberg BS, Mellinger JF, Schoenberg DG, et al: Moyamoya disease presenting as a seizure disorder. A case report. Arch Neurol 34:511–512, 1977

    • Search Google Scholar
    • Export Citation
  • 26.

    Servo A, & Puranen M: Moyamoya syndrome as a complication of radiation therapy. Case report. J Neurosurg 48:10261029, 1978 Servo A, Puranen M: Moyamoya syndrome as a complication of radiation therapy. Case report. J Neurosurg 48:1026–1029, 1978

    • Search Google Scholar
    • Export Citation
  • 27.

    Solomon GE, , Hilal SK, & Gold AP, et al. : Natural history of acute hemiplegia of childhood. Brain 93:107120, 1970 Solomon GE, Hilal SK, Gold AP, et al: Natural history of acute hemiplegia of childhood. Brain 93:107–120, 1970

    • Search Google Scholar
    • Export Citation
  • 28.

    Srinivas K, , Narayanan M, & Gopal S, et al. : Carotid arterial occlusion in identical twins with moyamoya. Arch Neurol 36:253254, 1979 (Letter) Srinivas K, Narayanan M, Gopal S, et al: Carotid arterial occlusion in identical twins with moyamoya. Arch Neurol 36:253–254, 1979 (Letter)

    • Search Google Scholar
    • Export Citation
  • 29.

    Sunder TR: Moyamoya disease in a patient with type I glycogenosis. Arch Neurol 38:251253, 1981 Sunder TR: Moyamoya disease in a patient with type I glycogenosis. Arch Neurol 38:251–253, 1981

    • Search Google Scholar
    • Export Citation
  • 30.

    Sundt TM Jr, , Siekert RG, & Piepgras DG, et al. : Bypass surgery for vascular disease of the carotid system. Mayo Clin Proc 51:677692, 1976 Sundt TM Jr, Siekert RG, Piepgras DG, et al: Bypass surgery for vascular disease of the carotid system. Mayo Clin Proc 51:677–692, 1976

    • Search Google Scholar
    • Export Citation
  • 31.

    Suzuki J, & Kodama N: Cerebrovascular “moyamoya” disease. Second report: collateral routes to forebrain via ethmoid sinus and superior nasal meatus. Angiology 22:223236, 1971 Suzuki J, Kodama N: Cerebrovascular “moyamoya” disease. Second report: collateral routes to forebrain via ethmoid sinus and superior nasal meatus. Angiology 22:223–236, 1971

    • Search Google Scholar
    • Export Citation
  • 32.

    Suzuki J, , Takaku A, & Kodama N, et al. : An attempt to treat cerebrovascular “moyamoya” disease in children. Childs Brain 1:193206, 1975 Suzuki J, Takaku A, Kodama N, et al: An attempt to treat cerebrovascular “moyamoya” disease in children. Childs Brain 1:193–206, 1975

    • Search Google Scholar
    • Export Citation
  • 33.

    Takeuchi S, , Tsuchida T, & Kobayashi K, et al. : Treatment of moyamoya disease by temporal muscle graft “encephalo-myo-synangiosis.” Childs Brain 10:115, 1983 Takeuchi S, Tsuchida T, Kobayashi K, et al: Treatment of moyamoya disease by temporal muscle graft “encephalo-myo-synangiosis.” Childs Brain 10:1–15, 1983

    • Search Google Scholar
    • Export Citation
  • 34.

    Taveras JM: Multiple progressive intracranial occlusions: a syndrome of children and young adults. AJR 106:235268, 1969 Taveras JM: Multiple progressive intracranial occlusions: a syndrome of children and young adults. AJR 106:235–268, 1969

    • Search Google Scholar
    • Export Citation
  • 35.

    Yamashita M, , Oka K, & Tanaka K: Histopathology of the brain vascular network in moyamoya disease. Stroke 14:5058, 1983 Yamashita M, Oka K, Tanaka K: Histopathology of the brain vascular network in moyamoya disease. Stroke 14:50–58, 1983

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 340 50 2
Full Text Views 233 4 0
PDF Downloads 105 3 0
EPUB Downloads 0 0 0