Experimental intracerebral hemorrhage: effects of a temporary mass lesion

E. J. Sinar F.R.C.S.1, A. David Mendelow F.R.C.S., Ph.D.1, David I. Graham Ph.D., F.R.C.Path.1, and Graham M. Teasdale M.R.C.P., F.R.C.S.1
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  • 1 Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland
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✓ Late pathophysiological events after the production and subsequent removal of an intracerebral mass were investigated using a mechanical microballoon model to simulate intracerebral hemorrhage. Immediately following balloon inflation in the caudate nucleus of rats, there was a significant increase in intracranial pressure to 14 ± 1 mm Hg (mean ± standard error of the mean), accompanied by a reduction in cerebral blood flow (CBF) in the ipsilateral frontal cortex, as measured by the hydrogen-clearance technique. Carbon-14-iodoantipyrine autoradiography revealed a significant reduction in the CBF of the ipsilateral caudate nucleus 4 hours after balloon inflation: 31% of the caudate nucleus had a CBF of less than 20 ml ⋅ 100 gm−1 ⋅ min−1 compared to only 1% in the sham-treated control group (balloon insertion without inflation). The rats with an intracerebral mass exhibited a significant increase in the volume of ischemic damage in the ipsilateral caudate nucleus (17.1% of total volume) compared to only 1.7% in the sham-treated group; however, there was no evidence of cerebral edema. Ischemic damage and reduced CBF persisted for 4 hours after transient inflation of a microballoon in the caudate nucleus. This suggests that ischemic damage occurs at the time of formation of the lesion and is not prevented by its early removal.

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  • 1.

    Ames A III, , Wright RL, & Kowada M, et al: Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52:437453, 1968 Ames A III, Wright RL, Kowada M, et al: Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52:437–453, 1968

    • Search Google Scholar
    • Export Citation
  • 2.

    Arana-Iñiguez R, , Wilson E, & Bastarrica E, et al: Cerebral hematomas. Surg Neurol 6:4552, 1976 Arana-Iñiguez R, Wilson E, Bastarrica E, et al: Cerebral hematomas. Surg Neurol 6:45–52, 1976

    • Search Google Scholar
    • Export Citation
  • 3.

    Bell BA, , Symon L, & Branston NM: CBF and time thresholds for the formation of ischemic cerebral edema, and effect of reperfusion in baboons. J Neurosurg 62:3141, 1985 Bell BA, Symon L, Branston NM: CBF and time thresholds for the formation of ischemic cerebral edema, and effect of reperfusion in baboons. J Neurosurg 62:31–41, 1985

    • Search Google Scholar
    • Export Citation
  • 4.

    Brierley JB, , Meldrum BS, & Brown AW: The threshold and neuropathology of cerebral “anoxic-ischemic” cell change. Arch Neurol 29:367374, 1973 Brierley JB, Meldrum BS, Brown AW: The threshold and neuropathology of cerebral “anoxic-ischemic” cell change. Arch Neurol 29:367–374, 1973

    • Search Google Scholar
    • Export Citation
  • 5.

    Brown AW, & Brierley JB: The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol 49:87106, 1968 Brown AW, Brierley JB: The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol 49:87–106, 1968

    • Search Google Scholar
    • Export Citation
  • 6.

    Bullock R, , Mendelow AD, , Teasdale GM, & et al: Intracranial haemorrhage induced at arterial pressure in the rat. Part 1: Description of technique, ICP changes and neuropathological findings. Neurol Res 6:184188, 1984 Bullock R, Mendelow AD, Teasdale GM, et al: Intracranial haemorrhage induced at arterial pressure in the rat. Part 1: Description of technique, ICP changes and neuropathological findings. Neurol Res 6:184–188, 1984

    • Search Google Scholar
    • Export Citation
  • 7.

    Crockard A, , Iannotti F, , Hunstock AT, & et al: Cerebral blood flow and edema following carotid occlusion in the gerbil. Stroke 11:494498, 1980 Crockard A, Iannotti F, Hunstock AT, et al: Cerebral blood flow and edema following carotid occlusion in the gerbil. Stroke 11:494–498, 1980

    • Search Google Scholar
    • Export Citation
  • 8.

    Crockard A, Kang J, Ladds G: A model of focal cortical contusion in gerbils. J Neurosurg 57:203–209, 1982

  • 9.

    Gotoh O, , Mohamed AA, & McCulloch J, et al: Nimodipine and the haemodynamic and histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 6:321331, 1986 Gotoh O, Mohamed AA, McCulloch J, et al: Nimodipine and the haemodynamic and histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 6:321–331, 1986

    • Search Google Scholar
    • Export Citation
  • 10.

    Haining JL, , Turner MD, & Pantall RM: Measurement of local cerebral blood flow in the unanesthetized rat using a hydrogen clearance method. Circ Res 23:313324, 1968 Haining JL, Turner MD, Pantall RM: Measurement of local cerebral blood flow in the unanesthetized rat using a hydrogen clearance method. Circ Res 23:313–324, 1968

    • Search Google Scholar
    • Export Citation
  • 11.

    Janny P, , Colnet G, & Georget AM, et al: Intracranial pressure with intracerebral hemorrhages. Surg Neurol 10:371375, 1978 Janny P, Colnet G, Georget AM, et al: Intracranial pressure with intracerebral hemorrhages. Surg Neurol 10:371–375, 1978

    • Search Google Scholar
    • Export Citation
  • 12.

    Kaufman HH, , Pruessner JL, & Bernstein DP, et al: A rabbit model of intracerebral hematoma. Acta Neuropathol 65:318321, 1985 Kaufman HH, Pruessner JL, Bernstein DP, et al: A rabbit model of intracerebral hematoma. Acta Neuropathol 65:318–321, 1985

    • Search Google Scholar
    • Export Citation
  • 13.

    König JFR, & Klippel RA: The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem. Baltimore: Williams & Wilkins, 1963 König JFR, Klippel RA: The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem. Baltimore: Williams & Wilkins, 1963

    • Search Google Scholar
    • Export Citation
  • 14.

    Lazorthes G: Surgery of cerebral hemorrhage. Report on the results of 52 surgically treated cases. J Neurosurg 16:355364, 1959 Lazorthes G: Surgery of cerebral hemorrhage. Report on the results of 52 surgically treated cases. J Neurosurg 16:355–364, 1959

    • Search Google Scholar
    • Export Citation
  • 15.

    Luessenhop AJ, , Shevlin WA, & Ferrero AA, et al: Surgical management of primary intracerebral hemorrhage. J Neurosurg 27:419427, 1967 Luessenhop AJ, Shevlin WA, Ferrero AA, et al: Surgical management of primary intracerebral hemorrhage. J Neurosurg 27:419–427, 1967

    • Search Google Scholar
    • Export Citation
  • 16.

    MacKenzie ET, , Strandgaard S, & Graham DI, et al: Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier. Circ Res 39:3341, 1976 MacKenzie ET, Strandgaard S, Graham DI, et al: Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier. Circ Res 39:33–41, 1976

    • Search Google Scholar
    • Export Citation
  • 17.

    McKissock W, , Richardson A, & Taylor J: Primary intracerebral haemorrhage. A controlled trial of surgical and conservative treatment in 180 unselected cases. Lancet 1:221226, 1961 McKissock W, Richardson A, Taylor J: Primary intracerebral haemorrhage. A controlled trial of surgical and conservative treatment in 180 unselected cases. Lancet 1:221–226, 1961

    • Search Google Scholar
    • Export Citation
  • 18.

    McKissock W, , Richardson A, & Walsh L: Primary intracerebral haemorrhage. Results of surgical treatment in 244 consecutive cases. Lancet 2:683686, 1959 McKissock W, Richardson A, Walsh L: Primary intracerebral haemorrhage. Results of surgical treatment in 244 consecutive cases. Lancet 2:683–686, 1959

    • Search Google Scholar
    • Export Citation
  • 19.

    Mendelow AD, , Bullock R, & Nath FP, et al: Experimental intracerebral haemorrhage: intracranial pressure changes and cerebral blood flow, in Miller JD, , Teasdale GM, & Rowan JO, et al (eds): Intracranial Pressure VI. Berlin: Springer-Verlag, 1986, pp 515520 Mendelow AD, Bullock R, Nath FP, et al: Experimental intracerebral haemorrhage: intracranial pressure changes and cerebral blood flow, in Miller JD, Teasdale GM, Rowan JO, et al (eds): Intracranial Pressure VI. Berlin: Springer-Verlag, 1986, pp 515–520

    • Search Google Scholar
    • Export Citation
  • 20.

    Mendelow AD, , Bullock R, & Teasdale GM, et al: Intracranial haemorrhage induced at arterial pressure in the rat. Part 2: Short term changes in local cerebral blood flow measured by autoradiography. Neurol Res 6:189193, 1984 Mendelow AD, Bullock R, Teasdale GM, et al: Intracranial haemorrhage induced at arterial pressure in the rat. Part 2: Short term changes in local cerebral blood flow measured by autoradiography. Neurol Res 6:189–193, 1984

    • Search Google Scholar
    • Export Citation
  • 21.

    Mitsuno T, , Kanaya H, & Shirakata S, et al: Surgical treatment of hypertensive intracerebral hemorrhage. J Neurosurg 24:7076, 1966 Mitsuno T, Kanaya H, Shirakata S, et al: Surgical treatment of hypertensive intracerebral hemorrhage. J Neurosurg 24:70–76, 1966

    • Search Google Scholar
    • Export Citation
  • 22.

    Osborne KA, , Shigeno T, & Balarsky AM, et al: Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. J Neurol Neurosurg Psychiatry( In press, 1987)Osborne KA, Shigeno T, Balarsky AM, et al: Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. J Neurol Neurosurg Psychiatry (In press, 1987)

    • Search Google Scholar
    • Export Citation
  • 23.

    Papo I, , Janny P, & Caruselli G, et al: Intracranial pressure time course in primary intracerebral hemorrhage. Neurosurgery 4:504511, 1979 Papo I, Janny P, Caruselli G, et al: Intracranial pressure time course in primary intracerebral hemorrhage. Neurosurgery 4:504–511, 1979

    • Search Google Scholar
    • Export Citation
  • 24.

    Sakurada O, , Kennedy C, & Jehle J, et al: Measurement of local cerebral blood flow with iodo[14C]antipyrine. Am J Physiol 234:H59H66, 1978 Sakurada O, Kennedy C, Jehle J, et al: Measurement of local cerebral blood flow with iodo[14C]antipyrine. Am J Physiol 234:H59–H66, 1978

    • Search Google Scholar
    • Export Citation
  • 25.

    Shigeno T, , Brock M, & Shigeno S, et al: The determination of brain water content: microgravimetry versus drying-weighing method. J Neurosurg 57:99107, 1982 Shigeno T, Brock M, Shigeno S, et al: The determination of brain water content: microgravimetry versus drying-weighing method. J Neurosurg 57:99–107, 1982

    • Search Google Scholar
    • Export Citation
  • 26.

    Symon L, , Branston NM, & Chikovani O: Ischemic brain edema following middle cerebral artery occlusion in baboons: relationship between regional cerebral water content and blood flow at 1 to 2 hours. Stroke 10:184191, 1979 Symon L, Branston NM, Chikovani O: Ischemic brain edema following middle cerebral artery occlusion in baboons: relationship between regional cerebral water content and blood flow at 1 to 2 hours. Stroke 10:184–191, 1979

    • Search Google Scholar
    • Export Citation
  • 27.

    Tazawa T, , Mizukami M, & Kawase T, et al: Size of hematoma and time course of intracranial pressure in patients with hypertensive intracerebral hemorrhage, in Ishii S, , Nagai H, & Brock M (eds): Intracranial Pressure V. Berlin: Springer-Verlag, 1983, pp 716720 Tazawa T, Mizukami M, Kawase T, et al: Size of hematoma and time course of intracranial pressure in patients with hypertensive intracerebral hemorrhage, in Ishii S, Nagai H, Brock M (eds): Intracranial Pressure V. Berlin: Springer-Verlag, 1983, pp 716–720

    • Search Google Scholar
    • Export Citation
  • 28.

    Tyson GW, , Teasdale GM, & Graham DI, et al: Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes. Ann Neurol 15:559567, 1984 Tyson GW, Teasdale GM, Graham DI, et al: Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes. Ann Neurol 15:559–567, 1984

    • Search Google Scholar
    • Export Citation

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