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Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter

Douglas S. DeWitt Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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Larry W. Jenkins Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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Enoch P. Wei Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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Harry Lutz Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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Donald P. Becker Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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 M.D.
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Hermes A. Kontos Departments of Surgery and Medicine, Richard Roland Reynolds Neurosurgical Research Laboratories, Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia

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Page Range:
787–794
Volume/Issue:
Volume 64: Issue 5
DOI link:
https://doi.org/10.3171/jns.1986.64.5.0787
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✓ The effects of two levels of fluid-percussion brain injury on cerebral blood flow (CBF) and pial arteriolar diameter were investigated in cats. Regional CBF was measured using the radioactive microsphere technique. Experimental brain injury resulted in changes in arterial blood pressure, CBF, and pial arteriolar diameter that were related to the severity of the injury. Low-level injury (1.88 ± 0.11 atm, mean ± standard error of the mean) resulted in a slight transient increase in CBF which had returned to preinjury levels by 30 minutes. High-level injury (2.68 ± 0.19 atm) resulted in larger, statistically significant (p < 0.01) increases in whole-brain CBF, decreases in cerebrovascular resistance, and increases in pial arteriolar diameter 1 minute postinjury. One hour after injury, CBF had returned to preinjury levels while cerebral perfusion pressure was significantly (p < 0.01) reduced. There was no evidence of reduced CBF in any region studied. Pial arterioles dilated during the posttraumatic hypertensive period and then returned to control diameters within 1 hour after injury. Changes in the diameter of pial arterioles were significantly correlated with posttraumatic changes in CBF.

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Address reprint requests to: Douglas S. DeWitt, Ph.D., Medical College of Virginia, P.O. Box 693, MCV Station, Richmond, Virginia 23298.
  • 1.

    Aukland K, , Bower BF, & Berliner RW: Measurement of local blood flow with hydrogen gas. Circ Res 14:164–187, 1964 Aukland K, Bower BF, Berliner RW: Measurement of local blood flow with hydrogen gas. Circ Res 14:164–187, 1964

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Brown GW, & Brown ML: Cardiovascular responses to experimental cerebral concussion in the rhesus monkey. Discussion of similarity of responses to electroconvulsive shock and cerebral concussion in dogs, monkeys, and man. Arch Neurol Psychiatry 71:707–713, 1954 Brown GW, Brown ML: Cardiovascular responses to experimental cerebral concussion in the rhesus monkey. Discussion of similarity of responses to electroconvulsive shock and cerebral concussion in dogs, monkeys, and man. Arch Neurol Psychiatry 71:707–713, 1954

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Bruce DA, , Langfitt TW, & Miller JD, et al: Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J Neurosurg 38:131–144, 1973 Bruce DA, Langfitt TW, Miller JD, et al: Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J Neurosurg 38:131–144, 1973

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Buckberg GD, , Luck JC, & Payne DB, et al: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604, 1971 Buckberg GD, Luck JC, Payne DB, et al: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604, 1971

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Capurro NL, , Goldstein RE, & Aamodt R, et al: Loss of microspheres from ischemic canine cardiac tissue. An important technical limitation. Circ Res 44:223–227, 1979 Capurro NL, Goldstein RE, Aamodt R, et al: Loss of microspheres from ischemic canine cardiac tissue. An important technical limitation. Circ Res 44:223–227, 1979

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    DeWitt DS, , Jenkins LW, & Lutz H, et al: Regional cerebral blood flow following fluid percussion injury. J Cereb Blood Flow Metab 1 (Suppl 1):S579–S580, 1981 DeWitt DS, Jenkins LW, Lutz H, et al: Regional cerebral blood flow following fluid percussion injury. J Cereb Blood Flow Metab 1 (Suppl 1):S579–S580, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Dole WP, , Jackson DL, & Rosenblatt JI, et al: Relative error and variability in blood flow measurements with radio-labeled microspheres. Am J Physiol 243:H371–H378, 1982 Dole WP, Jackson DL, Rosenblatt JI, et al: Relative error and variability in blood flow measurements with radio-labeled microspheres. Am J Physiol 243:H371–H378, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Domenech RJ, , Hoffman JIE, & Noble MIM, et al: Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res 25:581–596, 1969 Domenech RJ, Hoffman JIE, Noble MIM, et al: Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res 25:581–596, 1969

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Enevoldsen EM, , Cold G, & Hensen FT, et al: Dynamic changes in regional CBF, intraventricular pressure, CSF pH and lactate levels during the acute phase of head injury. J Neurosurg 44:191–214, 1976 Enevoldsen EM, Cold G, Hensen FT, et al: Dynamic changes in regional CBF, intraventricular pressure, CSF pH and lactate levels during the acute phase of head injury. J Neurosurg 44:191–214, 1976

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Fieschi C, , Battistini N, & Beduschi A, et al: Regional cerebral blood flow and intraventricular pressure in acute head injuries. J Neurol Neurosurg Psychiatry 37:1378–1388, 1974 Fieschi C, Battistini N, Beduschi A, et al: Regional cerebral blood flow and intraventricular pressure in acute head injuries. J Neurol Neurosurg Psychiatry 37:1378–1388, 1974

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Fieschi C, , Beduschi A, & Agnoli A, et al: Regional cerebral blood flow and intraventricular pressure in acute brain injuries. Eur Neurol 8:192–199, 1972 Fieschi C, Beduschi A, Agnoli A, et al: Regional cerebral blood flow and intraventricular pressure in acute brain injuries. Eur Neurol 8:192–199, 1972

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Fieschi C, , Bozzao L, & Agnoli A: Regional clearance of hydrogen as a measure of cerebral blood flow. Acta Neurol Scand Suppl 14:46–52, 1965 Fieschi C, Bozzao L, Agnoli A: Regional clearance of hydrogen as a measure of cerebral blood flow. Acta Neurol Scand Suppl 14:46–52, 1965

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Gennarelli TA, , Obrist WD, & Langfitt TW, et al: Vascular and metabolic reactivity to changes in PCO2 in head injured patients, in Popp AJ, , Bourke RS, & Nelson LR, et al (eds): Neural Trauma. New York: Reven Press, 1979, pp 1–8 Gennarelli TA, Obrist WD, Langfitt TW, et al: Vascular and metabolic reactivity to changes in PCO2 in head injured patients, in Popp AJ, Bourke RS, Nelson LR, et al (eds): Neural Trauma. New York: Reven Press, 1979, pp 1–8

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Gobiet W, , Grote W, & Bock WJ: The relationship between intracranial pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury. Acta Neurochir 32:13–24, 1975 Gobiet W, Grote W, Bock WJ: The relationship between intracranial pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury. Acta Neurochir 32:13–24, 1975

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Greenway CV, & Murthy VS: Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies. Br J Pharmacol 46:177–188, 1972 Greenway CV, Murthy VS: Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies. Br J Pharmacol 46:177–188, 1972

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Gross PM, , Heistad DD, & Strait MR, et al: Cerebral vascular responses to physiological stimulation of sympathetic pathways in cats. Circ Res 44:288–294, 1979 Gross PM, Heistad DD, Strait MR, et al: Cerebral vascular responses to physiological stimulation of sympathetic pathways in cats. Circ Res 44:288–294, 1979

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Hales JRS, & Cliff WJ: Direct observations of the behaviour of microspheres in microvasculature. Bibl Anat 15:87–91, 1977 Hales JRS, Cliff WJ: Direct observations of the behaviour of microspheres in microvasculature. Bibl Anat 15:87–91, 1977

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Heistad DD, , Marcus ML, & Busija DW: Measurement of cerebral blood flow in experimental animals with microspheres: applications of the method, in Passonneau JV, , Hawkins RA, & Lust WD, et al (eds): Cerebral Metabolism and Neural Function. Baltimore: Williams & Wilkins, 1980, pp 202–211 Heistad DD, Marcus ML, Busija DW: Measurement of cerebral blood flow in experimental animals with microspheres: applications of the method, in Passonneau JV, Hawkins RA, Lust WD, et al (eds): Cerebral Metabolism and Neural Function. Baltimore: Williams & Wilkins, 1980, pp 202–211

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Heistad DD, , Marcus ML, & Gross PM: Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey. Am J Physiol 235:H544–H552, 1978 Heistad DD, Marcus ML, Gross PM: Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey. Am J Physiol 235:H544–H552, 1978

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Heistad DD, , Marcus ML, & Sandberg S, et al: Effect of sympathetic nerve stimulation on cerebral blood flow and on large cerebral arteries of dogs. Circ Res 41:342–350, 1977 Heistad DD, Marcus ML, Sandberg S, et al: Effect of sympathetic nerve stimulation on cerebral blood flow and on large cerebral arteries of dogs. Circ Res 41:342–350, 1977

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Herbert DA, & Mitchell RA: Blood gas tensions and acid-base balance in awake cats. J Appl Physiol 30:434–436, 1971 Herbert DA, Mitchell RA: Blood gas tensions and acid-base balance in awake cats. J Appl Physiol 30:434–436, 1971

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Heymann MA, , Payne BD, & Hoffmann JIE, et al: Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 20:55–79, 1977 Heymann MA, Payne BD, Hoffmann JIE, et al: Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 20:55–79, 1977

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Hoffbrand BI, & Forsyth RP: Validity studies of the radioactive microsphere method for the study of the distribution of cardiac output, organ blood flow, and resistance in the conscious rhesus monkey. Cardiovasc Res 3:426–432, 1969 Hoffbrand BI, Forsyth RP: Validity studies of the radioactive microsphere method for the study of the distribution of cardiac output, organ blood flow, and resistance in the conscious rhesus monkey. Cardiovasc Res 3:426–432, 1969

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Hossmann KA, , Hossmann V, & Tayagi S: Microsphere analysis of local cerebral and extracerebral blood flow after complete ischemia of the cat brain for one hour. J Neurol 218:275–285, 1978 Hossmann KA, Hossmann V, Tayagi S: Microsphere analysis of local cerebral and extracerebral blood flow after complete ischemia of the cat brain for one hour. J Neurol 218:275–285, 1978

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Hoyer S, , Piscol K, & Stoeckel H, et al: CBF and metabolism in patients with acute brain injury with regard to autoregulation. Eur Neurol 8:174–180, 1972 Hoyer S, Piscol K, Stoeckel H, et al: CBF and metabolism in patients with acute brain injury with regard to autoregulation. Eur Neurol 8:174–180, 1972

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Hunziker O, , Frey H, & Schulz U: Morphometric investigations of capillaries in the brain cortex of the cat. Brain Res 65:1–11, 1974 Hunziker O, Frey H, Schulz U: Morphometric investigations of capillaries in the brain cortex of the cat. Brain Res 65:1–11, 1974

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Jackson DL, , Dole WP, & McGloin J, et al: Total cerebral 794 ischemia: application of a new model system to studies of cerebral microcirculation. Stroke 12:66–72, 1981 Jackson DL, Dole WP, McGloin J, et al: Total cerebral 794 ischemia: application of a new model system to studies of cerebral microcirculation. Stroke 12:66–72, 1981

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Jackson RT, , Clairmont AA, & Pollock RA: The effect of carbon dioxide inhalation on cerebral blood flow: a two-hour duration study in dogs with microspheres. Stroke 5:344–349, 1974 Jackson RT, Clairmont AA, Pollock RA: The effect of carbon dioxide inhalation on cerebral blood flow: a two-hour duration study in dogs with microspheres. Stroke 5:344–349, 1974

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Kennedy JC, & Taplin GV: Shunting in cerebral microcirculation. Am Surg 33:763–771, 1967 Kennedy JC, Taplin GV: Shunting in cerebral microcirculation. Am Surg 33:763–771, 1967

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Kontos HA, , Dietrich WD, & Wei EP, et al: Abnormalities of the cerebral microcirculation after traumatic injury: the relationship of hypertension and prostaglandins, in Eisenberg HM, & Suddith RL (eds): The Cerebral Microvasculature. Investigation of the Blood-Brain Barrier. New York: Plenum Press, 1980, pp 243–256 Kontos HA, Dietrich WD, Wei EP, et al: Abnormalities of the cerebral microcirculation after traumatic injury:the relationship of hypertension and prostaglandins, in Eisenberg HM, Suddith RL (eds): The Cerebral Microvasculature. Investigation of the Blood-Brain Barrier. New York: Plenum Press, 1980, pp 243–256

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Kontos HA, , Wei EP, & Navari RM, et al: Responses of cerebral arteries and arterioles to actue hypotension and hypertension. Am J Physiol 234:H371–H383, 1978 Kontos HA, Wei EP, Navari RM, et al: Responses of cerebral arteries and arterioles to actue hypotension and hypertension. Am J Physiol 234:H371–H383, 1978

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Langfitt TW, & Obrist WD: Cerebral blood flow and metabolism after intracranial trauma. Prog Neurol Surg 10:14–48, 1981 Langfitt TW, Obrist WD: Cerebral blood flow and metabolism after intracranial trauma. Prog Neurol Surg 10:14–48, 1981

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Lassen NA: The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. Lancet 2:1113–1115, 1966 Lassen NA: The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. Lancet 2:1113–1115, 1966

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Levasseur JE, , Wei EP, & Raper AJ, et al: Detailed description of a cranial window technique for acute and chronic experiments. Stroke 6:308–317, 1975 Levasseur JE, Wei EP, Raper AJ, et al: Detailed description of a cranial window technique for acute and chronic experiments. Stroke 6:308–317, 1975

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Lewelt W, , Jenkins LW, & Miller JD: Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain. J Neurosurg 53:500–511, 1980 Lewelt W, Jenkins LW, Miller JD: Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain. J Neurosurg 53:500–511, 1980

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Lewelt W, , Jenkins LW, & Miller JD: Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity to hypoxia and to hypercapnia. J Neurosurg 56:332–338, 1982 Lewelt W, Jenkins LW, Miller JD: Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity to hypoxia and to hypercapnia. J Neurosurg 56:332–338, 1982

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Marcus ML, , Busija DW, & Bischof CJ, et al: Methods for measurement of cerebral blood flow. Fed Proc 40:2306–2310, 1981 Marcus ML, Busija DW, Bischof CJ, et al: Methods for measurement of cerebral blood flow. Fed Proc 40:2306–2310, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Marcus ML, , Heistad DD, & Ehrhardt JC, et al: Total and regional cerebral blood flow measurement with 7–10, 15-, 25-, and 50-µm microspheres. J Appl Physiol 40:501–507, 1976 Marcus ML, Heistad DD, Ehrhardt JC, et al: Total and regional cerebral blood flow measurement with 7–10, 15-, 25-, and 50-µm microspheres. J Appl Physiol 40:501–507, 1976

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Maxwell LC, , Shepherd AP, & McMahan CA: Microsphere passage through intestinal circulation: via shunts or capillaries? Am J Physiol 248:H217–H224, 1985 Maxwell LC, Shepherd AP, McMahan CA: Microsphere passage through intestinal circulation: via shunts or capillaries? Am J Physiol 248:H217–H224, 1985

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Maxwell LC, , Shepherd AP, & Riedel GL: Vasodilation or altered perfusion pressure moves 15-µm spheres trapped in the gut wall. Am J Physiol 243:H123–H127, 1982 Maxwell LC, Shepherd AP, Riedel GL: Vasodilation or altered perfusion pressure moves 15-µm spheres trapped in the gut wall. Am J Physiol 243:H123–H127, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Mernagh JR, , Spiers EW, & Adiseshiah M: The measurement of radioactive microspheres in biological samples. Phys Med Biol 21:646–650, 1976 Mernagh JR, Spiers EW, Adiseshiah M: The measurement of radioactive microspheres in biological samples. Phys Med Biol 21:646–650, 1976

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Meyer JS, , Kondo A, & Nomura F, et al: Cerebral hemodynamics and metabolism following experimental head injury. J Neurosurg 32:304–319, 1970 Meyer JS, Kondo A, Nomura F, et al: Cerebral hemodynamics and metabolism following experimental head injury. J Neurosurg 32:304–319, 1970

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Moore CD, , Gewertz BL, & Wheller HT, et al: An additional source of error in microsphere measurement of regional cerebral blood flow. Microvasc Res 21:377–383, 1981 Moore CD, Gewertz BL, Wheller HT, et al: An additional source of error in microsphere measurement of regional cerebral blood flow. Microvasc Res 21:377–383, 1981

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Nilsson B, & Pontén U: Experimental head injury in the rat. Part 2: Regional brain energy metabolism in concussive trauma. J Neurosurg 47:252–261, 1977 Nilsson B, Pontén U: Experimental head injury in the rat. Part 2: Regional brain energy metabolism in concussive trauma. J Neurosurg 47:252–261, 1977

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Overgaard J, & Tweed WA: Cerebral circulation after head injury. Part 1: Cerebral blood flow and its regulation after closed head injury with emphasis on clinical correlations. J Neurosurg 41:531–541, 1974 Overgaard J, Tweed WA: Cerebral circulation after head injury. Part 1: Cerebral blood flow and its regulation after closed head injury with emphasis on clinical correlations. J Neurosurg 41:531–541, 1974

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Phibbs RH, & Dong L: Nonuniform distribution of microspheres in blood flowing through a medium-size artery. Can J Physiol Pharmacol 48:415–421, 1970 Phibbs RH, Dong L: Nonuniform distribution of microspheres in blood flowing through a medium-size artery. Can J Physiol Pharmacol 48:415–421, 1970

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Phibbs RH, , Wyler F, & Neutze J: Rheology of microspheres injected into circulation of rabbits. Nature 216:1339–1340, 1967 Phibbs RH, Wyler F, Neutze J: Rheology of microspheres injected into circulation of rabbits. Nature 216:1339–1340, 1967

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Rudolph AM, & Heymann MA: The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21:163–184, 1967 Rudolph AM, Heymann MA: The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21:163–184, 1967

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Saunders ML, , Miller JD, & Stablein D, et al: The effects of graded experimental trauma on cerebral blood flow and responsiveness to CO2. J Neurosurg 51:18–26, 1979 Saunders ML, Miller JD, Stablein D, et al: The effects of graded experimental trauma on cerebral blood flow and responsiveness to CO2. J Neurosurg 51:18–26, 1979

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Sullivan HG, , Martinez J, & Becker DP, et al: Fluid-percussion model of mechanical brain injury in the cat. J Neurosurg 45:520–534, 1976 Sullivan HG, Martinez J, Becker DP, et al: Fluid-percussion model of mechanical brain injury in the cat. J Neurosurg 45:520–534, 1976

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Wagner HN Jr, , Rhodes BA, & Sasaki Y, et al: Studies of the circulation with radioactive microspheres. Invest Radiol 4:374–386, 1969 Wagner HN Jr, Rhodes BA, Sasaki Y, et al: Studies of the circulation with radioactive microspheres. Invest Radiol 4:374–386, 1969

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Wei EP, , Dietrich WD, & Povlishock JT, et al: Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 46:37–47, 1980 Wei EP, Dietrich WD, Povlishock JT, et al: Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 46:37–47, 1980

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Wei EP, , Kontos HA, & Patterson JL Jr: Dependence of pial arteriolar response to hypercapnia on vessel size. Am J Physiol 238:H697–H703, 1980 Wei EP, Kontos HA, Patterson JL Jr: Dependence of pial arteriolar response to hypercapnia on vessel size. Am J Physiol 238:H697–H703, 1980

    • PubMed
    • Search Google Scholar
    • Export Citation

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