Skull metastasis of thyroid carcinoma

Study of 12 cases

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  • 1 Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine; Department of Surgery, Sendai City Hospital; and Second Department of Surgery, Tohoku University School of Medicine, Sendai, Japan
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✓ Over the past 33 years the authors have treated 12 cases of skull metastasis from thyroid carcinoma, accounting for 2.5% of a total of 473 cases of thyroid cancer. A study of these 12 cases revealed the following characteristics. 1) The mean age of the patients was 60.4 years and the predominant incidence was in the seventh decade of life. 2) The incidence of skull metastasis from thyroid cancer was higher among women than among men. 3) The primary sign was a soft hemispheric tumor resting on the skull. 4) The tumors were rich in vascularity with osteolytic changes in the skull. 5) The average period from diagnosis of the thyroid tumor until thyroidectomy was 14.3 years, and until discovery of the skull metastasis was 23.3 years. The clinical course was thus very long. 6) The most frequent histopathological presentation was follicular adenocarcinoma. Such lesions were morphologically well differentiated, with little pleomorphism and atypism, but detailed examination showed infiltration into the vascular lumen or capsule. 7) The mean survival time in these patients was 4.5 years from the time of diagnosis. The prognosis in this lesion was relatively poor, considering its long clinical course.

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  • 1.

    Abrams HL: Skeletal metastases in carcinoma. Radiology 55:534538, 1950 Abrams HL: Skeletal metastases in carcinoma. Radiology 55:534–538, 1950

    • Search Google Scholar
    • Export Citation
  • 2.

    Abrams HL, , Spiro R, & Goldstein N: Metastasis in carcinoma. Analysis of 1000 autopsied cases. Cancer 3:7485, 1950 Abrams HL, Spiro R, Goldstein N: Metastasis in carcinoma. Analysis of 1000 autopsied cases. Cancer 3:74–85, 1950

    • Search Google Scholar
    • Export Citation
  • 3.

    Aoki A, & Kwak R: [ A case of skull metastasis of malignant struma.] No To Shinkei 24:16571660, 1972 (Jpn) Aoki A, Kwak R: [A case of skull metastasis of malignant struma.] No To Shinkei 24:1657–1660, 1972 (Jpn)

    • Search Google Scholar
    • Export Citation
  • 4.

    Bru A, , Combes PF, & Naja A: Localisations et aspects radiologiques des métastases osseuses des cancers thyroüdiens. J Radiol Electrol 44:872876, 1963 Bru A, Combes PF, Naja A: Localisations et aspects radiologiques des métastases osseuses des cancers thyroüdiens. J Radiol Electrol 44:872–876, 1963

    • Search Google Scholar
    • Export Citation
  • 5.

    Catz B, , Petit D, & Starr P: The diagnostic and therapeutic value of thyrotropic hormone and heavy dosage scintigrams for the demonstration of thyroid cancer metastases. Am J Med Sci 237:158164, 1959 Catz B, Petit D, Starr P: The diagnostic and therapeutic value of thyrotropic hormone and heavy dosage scintigrams for the demonstration of thyroid cancer metastases. Am J Med Sci 237:158–164, 1959

    • Search Google Scholar
    • Export Citation
  • 6.

    Cohnheim J: Einfacher Gallertkropt mit Metastasen. Virchow Arch (Pathol Anat) 68:547554, 1876 Cohnheim J: Einfacher Gallertkropt mit Metastasen. Virchow Arch (Pathol Anat) 68:547–554, 1876

    • Search Google Scholar
    • Export Citation
  • 7.

    Crile G Jr: The endocrine dependency of papillary carcinomas of the thyroid, in Smithers D (ed): Tumours of the Thyroid Gland. Edinburgh: Churchill Livingstone, 1970, Vol 6, pp 269275 Crile G Jr: The endocrine dependency of papillary carcinomas of the thyroid, in Smithers D (ed): Tumours of the Thyroid Gland. Edinburgh: Churchill Livingstone, 1970, Vol 6, pp 269–275

    • Search Google Scholar
    • Export Citation
  • 8.

    Dinsmore RS, & Hicken NF: Metastases from malignant tumors of the thyroid. A study of 124 cases. Am J Surg 24:202224, 1934 Dinsmore RS, Hicken NF: Metastases from malignant tumors of the thyroid. A study of 124 cases. Am J Surg 24:202–224, 1934

    • Search Google Scholar
    • Export Citation
  • 9.

    Hubeny MJ, & Mass M: Roentgenologic aspects of metastases. Radiology 35:315321, 1940 Hubeny MJ, Mass M: Roentgenologic aspects of metastases. Radiology 35:315–321, 1940

    • Search Google Scholar
    • Export Citation
  • 10.

    Krishnamurthy GT, & Blahd WH: Radioiodine 1-131 therapy in the management of thyroid cancer. A prospective study. Cancer 40:195202, 1977 Krishnamurthy GT, Blahd WH: Radioiodine 1-131 therapy in the management of thyroid cancer. A prospective study. Cancer 40:195–202, 1977

    • Search Google Scholar
    • Export Citation
  • 11.

    Langhans T: Über die epithelialen Formen der malignen Struma. Virchows Arch (Pathol Anat) 189:69152, 1907 Langhans T: Über die epithelialen Formen der malignen Struma. Virchows Arch (Pathol Anat) 189:69–152, 1907

    • Search Google Scholar
    • Export Citation
  • 12.

    McCormack KR: Bone metastases from thyroid carcinoma. Cancer 19:181184, 1966 McCormack KR: Bone metastases from thyroid carcinoma. Cancer 19:181–184, 1966

    • Search Google Scholar
    • Export Citation
  • 13.

    Nagamine Y, , Komatsu S, & Suzuki J: New embolization method using estrogen: effect of estrogen on microcirculation. Surg Neurol 20:269275, 1983 Nagamine Y, Komatsu S, Suzuki J: New embolization method using estrogen: effect of estrogen on microcirculation. Surg Neurol 20:269–275, 1983

    • Search Google Scholar
    • Export Citation
  • 14.

    Ouchi K: Pathology of follicular thyroid adenoma regarding malignant and regressive changes. Tohoku J Exp Med 81:7084, 1963 Ouchi K: Pathology of follicular thyroid adenoma regarding malignant and regressive changes. Tohoku J Exp Med 81:70–84, 1963

    • Search Google Scholar
    • Export Citation
  • 15.

    Sato H, , Sato K, & Sato Y, et al: [ Clinical cancer chemotherapy based on the experimental findings of selective enhancement of drug delivery to tumor tissue by angiotensin II.] Jpn J Cancer Chemother 8 (Suppl l):91100, 1981 (Jpn) Sato H, Sato K, Sato Y, et al: [Clinical cancer chemotherapy based on the experimental findings of selective enhancement of drug delivery to tumor tissue by angiotensin II.] Jpn J Cancer Chemother 8 (Suppl l):91–100, 1981 (Jpn)

    • Search Google Scholar
    • Export Citation
  • 16.

    Seidlin SM: Radioiodine in the treatment of metastatic thyroid carcinoma. Med Clin North Am 36:663680, 1952 Seidlin SM: Radioiodine in the treatment of metastatic thyroid carcinoma. Med Clin North Am 36:663–680, 1952

    • Search Google Scholar
    • Export Citation
  • 17.

    Sherman RS, & Ivker M: The roentgen appearance of thyroid metastases in bone. AJR 63:196203, 1950 Sherman RS, Ivker M: The roentgen appearance of thyroid metastases in bone. AJR 63:196–203, 1950

    • Search Google Scholar
    • Export Citation
  • 18.

    Simpson WM: A clinical and pathological study of fifty-five malignant neoplasms of the thyroid gland. Ann Clin Med 4:643667, 1926 Simpson WM: A clinical and pathological study of fifty-five malignant neoplasms of the thyroid gland. Ann Clin Med 4:643–667, 1926

    • Search Google Scholar
    • Export Citation
  • 19.

    Sturgeon CT, , Davis FE, & Catz B, et al: Treatment of thyroid cancer metastases with TSH and I131 during thyroid hormone medication. J Clin Endocrinol Metab 13:13911407, 1953 Sturgeon CT, Davis FE, Catz B, et al: Treatment of thyroid cancer metastases with TSH and I131 during thyroid hormone medication. J Clin Endocrinol Metab 13:1391–1407, 1953

    • Search Google Scholar
    • Export Citation
  • 20.

    Suzuki J, & Komatsu S: New embolization method using estrogen for dural arteriovenous malformation and meningioma. Surg Neurol 16:438442, 1981 Suzuki J, Komatsu S: New embolization method using estrogen for dural arteriovenous malformation and meningioma. Surg Neurol 16:438–442, 1981

    • Search Google Scholar
    • Export Citation
  • 21.

    Suzuki J, , Kwak R, & Aoki A, et al: [ Skull metastasis of malignant struma.] No To Shinkei 24:11211128, 1972 (Jpn) Suzuki J, Kwak R, Aoki A, et al: [Skull metastasis of malignant struma.] No To Shinkei 24:1121–1128, 1972 (Jpn)

    • Search Google Scholar
    • Export Citation
  • 22.

    Svyatukhina OV, , Lazarev NI, & Lunkova YT: Endocrine aspects of thyroid cancer therapy, in Hedinger CE (ed): Thyroid Cancer. Berlin/Heidelberg/New York: Springer-Verlag, 1969, pp 266268 Svyatukhina OV, Lazarev NI, Lunkova YT: Endocrine aspects of thyroid cancer therapy, in Hedinger CE (ed): Thyroid Cancer. Berlin/Heidelberg/New York: Springer-Verlag, 1969, pp 266–268

    • Search Google Scholar
    • Export Citation
  • 23.

    Tubiana M, , Lalanne CM, & Bergiron C, et al: Results obtained with radiotherapy in case of thyroid cancer, in Hedinger CE (ed): Thyroid Cancer. Berlin/Heidelberg/New York: Springer-Verlag, 1969, pp 279288 Tubiana M, Lalanne CM, Bergiron C, et al: Results obtained with radiotherapy in case of thyroid cancer, in Hedinger CE (ed): Thyroid Cancer. Berlin/Heidelberg/New York: Springer-Verlag, 1969, pp 279–288

    • Search Google Scholar
    • Export Citation

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