Prediction of survival in glioma patients by means of positron emission tomography

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  • 1 Neuroimaging Section, and Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke; Biometric Research Branch, National Cancer Institute; and the Nuclear Medicine Department, Clinical Center of the National Institutes of Health, Bethesda, Maryland
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✓ The aim of this study was to determine whether positron emission tomography (PET) with fluorine-18 (18F)-2-deoxyglucose (FDG) can be used as a prognostic test in patients with high-grade cerebral gliomas, regardless of the treatment given. Forty-five patients with astrocytoma Grade III or IV were included in this analysis. The mean survival time of patients with tumors exhibiting high glucose utilization as determined by PET-FDG was 5 months, whereas patients with gliomas showing lower glucose utilization had a mean survival period of 19 months. It is postulated that PET-FDG scans reflect the biological behavior of high-grade astrocytomas and may be used to predict the survival time of patients harboring such neoplasms.

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Contributor Notes

Address reprint requests to: Giovanni Di Chiro, M.D., Neuroimaging Section, Clinical Center, Building 10, Room 1C453, National Institutes of Health, Bethesda, Maryland 20205.
  • 1.

    Allen N: Oxidative metabolism of brain tumors. Prog Exp Tumor Res 17:192209, 1972 Allen N: Oxidative metabolism of brain tumors. Prog Exp Tumor Res 17:192–209, 1972

    • Search Google Scholar
    • Export Citation
  • 2.

    Andreou J, , George AE, & Wise A, et al: CT prognostic criteria of survival after malignant glioma surgery. AJNR 4:488490, 1983 Andreou J, George AE, Wise A, et al: CT prognostic criteria of survival after malignant glioma surgery. AJNR 4:488–490, 1983

    • Search Google Scholar
    • Export Citation
  • 3.

    Brooks RA: Alternate formula for glucose utilization using labeled deoxyglucose. J Nucl Med 23:538539, 1982 Brooks RA: Alternate formula for glucose utilization using labeled deoxyglucose. J Nucl Med 23:538–539, 1982

    • Search Google Scholar
    • Export Citation
  • 4.

    Butler AR, , Horii SC, & Kricheff II, et al: Computed tomography in astrocytomas. A statistical analysis of the parameters of malignancy and the positive contrast-enhanced CT scan. Radiology 129:433439, 1978 Butler AR, Horii SC, Kricheff II, et al: Computed tomography in astrocytomas. A statistical analysis of the parameters of malignancy and the positive contrast-enhanced CT scan. Radiology 129:433–439, 1978

    • Search Google Scholar
    • Export Citation
  • 5.

    Cox D: Regression models and life tables. J R Stat Soc (B) 34:187202, 1972 Cox D: Regression models and life tables. J R Stat Soc (B) 34:187–202, 1972

    • Search Google Scholar
    • Export Citation
  • 6.

    Crocker EF, , Zimmerman RA, & Phelps ME, et al: The effect of steroids on the extravascular distribution of radiographic contrast material and technetium pertechnetate in brain tumors as determined by computed tomography. Radiology 119:471474, 1976 Crocker EF, Zimmerman RA, Phelps ME, et al: The effect of steroids on the extravascular distribution of radiographic contrast material and technetium pertechnetate in brain tumors as determined by computed tomography. Radiology 119:471–474, 1976

    • Search Google Scholar
    • Export Citation
  • 7.

    Di Chiro G, , Brooks RA, & Patronas NJ, et al: Issues in the in vivo measurement of glucose metabolism of human central nervous system tumors. Ann Neurol 15 (Suppl):S138S146, 1984 Di Chiro G, Brooks RA, Patronas NJ, et al: Issues in the in vivo measurement of glucose metabolism of human central nervous system tumors. Ann Neurol 15 (Suppl):S138–S146, 1984

    • Search Google Scholar
    • Export Citation
  • 8.

    Di Chiro G, , Brooks RA, & Sokoloff L, et al: Glycolytic rate and histologic grade of human cerebral gliomas: a study with 18F fluorodeoxyglucose and positron emission tomography, in Heiss WD, & Phelps ME (eds): Positron Emission Tomography of the Brain. Berlin/Heidelberg/New York: Springer-Verlag, 1983, pp 181191 Di Chiro G, Brooks RA, Sokoloff L, et al: Glycolytic rate and histologic grade of human cerebral gliomas: a study with 18F fluorodeoxyglucose and positron emission tomography, in Heiss WD, Phelps ME (eds): Positron Emission Tomography of the Brain. Berlin/Heidelberg/New York: Springer-Verlag, 1983, pp 181–191

    • Search Google Scholar
    • Export Citation
  • 9.

    Di Chiro G, , DeLaPaz RL, & Brooks RA, et al: Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. Neurology 32:13231329, 1982 Di Chiro G, DeLaPaz RL, Brooks RA, et al: Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. Neurology 32:1323–1329, 1982

    • Search Google Scholar
    • Export Citation
  • 10.

    Di Chiro G, , Oldfield E, & Bairamian D, et al: Metabolic imaging of the brain stem and spinal cord: studies with positron emission tomography using 18F-2-deoxyglucose in normal and pathological cases. J Comput Assist Tomogr 7:937945, 1983 Di Chiro G, Oldfield E, Bairamian D, et al: Metabolic imaging of the brain stem and spinal cord: studies with positron emission tomography using 18F-2-deoxyglucose in normal and pathological cases. J Comput Assist Tomogr 7:937–945, 1983

    • Search Google Scholar
    • Export Citation
  • 11.

    Dickens F, & Šimer F: The metabolism of normal and tumour tissue. II. The respiratory quotient, and the relationship of respiration to glycolysis. Biochem J 24:13011326, 1930 Dickens F, Šimer F: The metabolism of normal and tumour tissue. II. The respiratory quotient, and the relationship of respiration to glycolysis. Biochem J 24:1301–1326, 1930

    • Search Google Scholar
    • Export Citation
  • 12.

    Dohr H: Über die Atmung von menschlichen Hirn-tumoren und Hirngewebe in vitro. Acta Neurochir 9:543553, 1961 Dohr H: Über die Atmung von menschlichen Hirn-tumoren und Hirngewebe in vitro. Acta Neurochir 9:543–553, 1961

    • Search Google Scholar
    • Export Citation
  • 13.

    Gehan EA, & Walker MD: Prognostic factors for patients with brain tumors. Natl Cancer Inst Monogr 46:189195, 1977 Gehan EA, Walker MD: Prognostic factors for patients with brain tumors. Natl Cancer Inst Monogr 46:189–195, 1977

    • Search Google Scholar
    • Export Citation
  • 14.

    Heller IH, & Elliott KAC: The metabolism of normal brain and human gliomas in relation to cell type and density. Can J Biochem Physiol 33:395403, 1955 Heller IH, Elliott KAC: The metabolism of normal brain and human gliomas in relation to cell type and density. Can J Biochem Physiol 33:395–403, 1955

    • Search Google Scholar
    • Export Citation
  • 15.

    Kaplan E, & Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457481, 1958 Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481, 1958

    • Search Google Scholar
    • Export Citation
  • 16.

    Kirsch WM, , Tucker WS, & Tabuchi K, et al: The metabolism of the glioblastoma: pathological correlates. Clin Neurosurg 25:310325, 1978 Kirsch WM, Tucker WS, Tabuchi K, et al: The metabolism of the glioblastoma: pathological correlates. Clin Neurosurg 25:310–325, 1978

    • Search Google Scholar
    • Export Citation
  • 17.

    Kornblith PL, , Cummins CJ, & Smith BH, et al: Correlation of experimental and clinical studies of metabolism by PET scanning. Prog Exp Brain Tumor Res 27:170178, 1984 Kornblith PL, Cummins CJ, Smith BH, et al: Correlation of experimental and clinical studies of metabolism by PET scanning. Prog Exp Brain Tumor Res 27:170–178, 1984

    • Search Google Scholar
    • Export Citation
  • 18.

    Leibel SA, , Sheline GE, & Wara WM, et al: The role of radiation therapy in the treatment of astrocytomas. Cancer 35:15511557, 1975 Leibel SA, Sheline GE, Wara WM, et al: The role of radiation therapy in the treatment of astrocytomas. Cancer 35:1551–1557, 1975

    • Search Google Scholar
    • Export Citation
  • 19.

    Levin VA, , Hoffman WF, & Heilbron DC, et al: Prognostic significance of the pretreatment CT scan on time to progression for patients with malignant gliomas. J Neurosurg 52:642647, 1980 Levin VA, Hoffman WF, Heilbron DC, et al: Prognostic significance of the pretreatment CT scan on time to progression for patients with malignant gliomas. J Neurosurg 52:642–647, 1980

    • Search Google Scholar
    • Export Citation
  • 20.

    Lilja A, , Bergström K, & Sannare B, et al: Reliability of computed tomography in assessing histopathological features of malignant supratentorial gliomas. J Comput Assist Tomogr 5:625636, 1981 Lilja A, Bergström K, Sannare B, et al: Reliability of computed tomography in assessing histopathological features of malignant supratentorial gliomas. J Comput Assist Tomogr 5:625–636, 1981

    • Search Google Scholar
    • Export Citation
  • 21.

    Macbeth RAL, & Bekesi JG: Oxygen consumption and anaerobic glycolysis of human malignant and normal tissue. Cancer Res 22:244248, 1962 Macbeth RAL, Bekesi JG: Oxygen consumption and anaerobic glycolysis of human malignant and normal tissue. Cancer Res 22:244–248, 1962

    • Search Google Scholar
    • Export Citation
  • 22.

    Mahaley MS Jr: The in vitro respiration of normal brain and brain tumors. Cancer Res 26:195197, 1966 Mahaley MS Jr: The in vitro respiration of normal brain and brain tumors. Cancer Res 26:195–197, 1966

    • Search Google Scholar
    • Export Citation
  • 23.

    Marks JE, & Gado M: Serial computed tomography of primary brain tumors following surgery, irradiation, and chemotherapy. Radiology 125:119125, 1977 Marks JE, Gado M: Serial computed tomography of primary brain tumors following surgery, irradiation, and chemotherapy. Radiology 125:119–125, 1977

    • Search Google Scholar
    • Export Citation
  • 24.

    Neuwelt EA, , Diehl JT, & Vu LH, et al: Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption. Ann Intern Med 94:449454, 1981 Neuwelt EA, Diehl JT, Vu LH, et al: Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption. Ann Intern Med 94:449–454, 1981

    • Search Google Scholar
    • Export Citation
  • 25.

    Patronas NJ, , Di Chiro G, & Brooks RA, et al: Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 144:885889, 1982 Patronas NJ, Di Chiro G, Brooks RA, et al: Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 144:885–889, 1982

    • Search Google Scholar
    • Export Citation
  • 26.

    Perria L, , Viale G, & Ibba F, et al: Istocitochimica dei tumori endocranici. Neuropsichiatria 20:419532, 1964 Perria L, Viale G, Ibba F, et al: Istocitochimica dei tumori endocranici. Neuropsichiatria 20:419–532, 1964

    • Search Google Scholar
    • Export Citation
  • 27.

    Reeves GI, & Marks JE: Prognostic significance of lesion size for glioblastoma multiforme. Radiology 132:469471, 1979 Reeves GI, Marks JE: Prognostic significance of lesion size for glioblastoma multiforme. Radiology 132:469–471, 1979

    • Search Google Scholar
    • Export Citation
  • 28.

    Sank VJ, , Brooks RA, & Friauf WS, et al: Performance evaluation and calibration of the Neuro-PET scanner. IEEE Trans Nucl Sci 30:636645, 1983 Sank VJ, Brooks RA, Friauf WS, et al: Performance evaluation and calibration of the Neuro-PET scanner. IEEE Trans Nucl Sci 30:636–645, 1983

    • Search Google Scholar
    • Export Citation
  • 29.

    Silverman C, & Marks JE: Prognostic significance of contrast enhancement in low-grade astrocytomas of the adult cerebrum. Radiology 139:211213, 1981 Silverman C, Marks JE: Prognostic significance of contrast enhancement in low-grade astrocytomas of the adult cerebrum. Radiology 139:211–213, 1981

    • Search Google Scholar
    • Export Citation
  • 30.

    Tchang S, , Scotti G, & Terbrugge K, et al: Computerized tomography as a possible aid to histological grading of supratentorial gliomas. J Neurosurg 46:735739, 1977 Tchang S, Scotti G, Terbrugge K, et al: Computerized tomography as a possible aid to histological grading of supratentorial gliomas. J Neurosurg 46:735–739, 1977

    • Search Google Scholar
    • Export Citation
  • 31.

    Timperley WR: Glycolysis in neuroectodermal tumours, in Thomas DGT, & Graham DI (eds): Brain Tumours. Scientific Basis, Clinical Investigation, and Current Therapy. London: Butterworths, 1980, pp 145167 Timperley WR: Glycolysis in neuroectodermal tumours, in Thomas DGT, Graham DI (eds): Brain Tumours. Scientific Basis, Clinical Investigation, and Current Therapy. London: Butterworths, 1980, pp 145–167

    • Search Google Scholar
    • Export Citation
  • 32.

    Walker MD: Malignant glioma, in Wilson CB, & Hoff JT (eds): Current Surgical Management of Neurologic Disease. New York/Edinburgh/London: Churchill Livingstone, 1980, pp 7278 Walker MD: Malignant glioma, in Wilson CB, Hoff JT (eds): Current Surgical Management of Neurologic Disease. New York/Edinburgh/London: Churchill Livingstone, 1980, pp 72–78

    • Search Google Scholar
    • Export Citation
  • 33.

    Warburg O: On the origin of cancer cells. Science 123:309314, 1956 Warburg O: On the origin of cancer cells. Science 123:309–314, 1956

    • Search Google Scholar
    • Export Citation
  • 34.

    Weber G: Enzymology of cancer cells (first of two parts). N Engl J Med 296:486493, 1977 Weber G: Enzymology of cancer cells (first of two parts). N Engl J Med 296:486–493, 1977

    • Search Google Scholar
    • Export Citation
  • 35.

    Weber G: Enzymology of cancer cells (second of two parts). N Engl J Med 296:541551, 1977 Weber G: Enzymology of cancer cells (second of two parts). N Engl J Med 296:541–551, 1977

    • Search Google Scholar
    • Export Citation
  • 36.

    Weinhouse S: Glycolysis, respiration, and anomalous gene expression in experimental hepatomas. Cancer Res 32:20072016, 1972 Weinhouse S: Glycolysis, respiration, and anomalous gene expression in experimental hepatomas. Cancer Res 32:2007–2016, 1972

    • Search Google Scholar
    • Export Citation
  • 37.

    Wickbom I: Tumor circulation, in Newton TH, & Potts DG (eds): Radiology of the Skull and Brain. St Louis: CV Mosby, 1974, Vol 2, pp 22572285 Wickbom I: Tumor circulation, in Newton TH, Potts DG (eds): Radiology of the Skull and Brain. St Louis: CV Mosby, 1974, Vol 2, pp 2257–2285

    • Search Google Scholar
    • Export Citation
  • 38.

    Wollemann M: Biochemistry of brain tumors, in Lajtha A (ed): Pathological Chemistry of the Nervous System. Handbook of Neurochemistry, Vol 7. New York: Plenum Press, 1972, pp 503542 Wollemann M: Biochemistry of brain tumors, in Lajtha A (ed): Pathological Chemistry of the Nervous System. Handbook of Neurochemistry, Vol 7. New York: Plenum Press, 1972, pp 503–542

    • Search Google Scholar
    • Export Citation

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