✓ A case of multiple cerebral hemorrhages following chymopapain chemonucleolysis is reported. The authors believe the probable etiology was intrathecal extravasation of chymopapain after injection of the drug into a lumbar disc space.
GarvinPJ, , JenningsRB, & SmithL, et al: Chymopapain: a pharmacologic and toxicologic evaluation in experimental animals.Clin Orthop41:204–223, 1965Garvin PJ, Jennings RB, Smith L, et al: Chymopapain: a pharmacologic and toxicologic evaluation in experimental animals. Clin Orthop 41:204–223, 1965
GarvinPJ, JenningsRB, SmithL, et al: Chymopapain: a pharmacologic and toxicologic evaluation in experimental animals.Clin Orthop41:204–223, 1965Garvin PJ, Jennings RB, Smith L, et al: Chymopapain: a pharmacologic and toxicologic evaluation in experimental animals. Clin Orthop 41:204–223, 1965)| false
LeavittF, , GarronDC, & WhislerWW, et al: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale.Clin Orthop146:136–143, 1980Leavitt F, Garron DC, Whisler WW, et al: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale. Clin Orthop 146:136–143, 1980
LeavittF, GarronDC, WhislerWW, et al: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale.Clin Orthop146:136–143, 1980Leavitt F, Garron DC, Whisler WW, et al: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale. Clin Orthop 146:136–143, 1980)| false
JavidMJ, , NordbyEJ, & FordLT, et al: Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study.JAMA249:2489–2494, 1983Javid MJ, Nordby EJ, Ford LT, et al: Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study. JAMA 249:2489–2494, 1983
JavidMJ, NordbyEJ, FordLT, et al: Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study.JAMA249:2489–2494, 1983Javid MJ, Nordby EJ, Ford LT, et al: Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study. JAMA 249:2489–2494, 1983)| false
MartinsAN, , RamirezA, & JohnstonJ, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results.J Neurosurg49:816–827, 1978Martins AN, Ramirez A, Johnston J, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results. J Neurosurg 49:816–827, 1978
MartinsAN, RamirezA, JohnstonJ, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results.J Neurosurg49:816–827, 1978Martins AN, Ramirez A, Johnston J, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results. J Neurosurg 49:816–827, 1978)| false
McCullochJA: Chemonucleolysis for relief of sciatica due to a herniated intervertebral disc.Can Med Assoc J124:879–882, 1981McCulloch JA: Chemonucleolysis for relief of sciatica due to a herniated intervertebral disc. Can Med Assoc J 124:879–882, 1981
McCullochJA: Chemonucleolysis for relief of sciatica due to a herniated intervertebral disc.Can Med Assoc J124:879–882, 1981McCulloch JA: Chemonucleolysis for relief of sciatica due to a herniated intervertebral disc. Can Med Assoc J 124:879–882, 1981)| false
SchwetschenauPR, , RamirezA, & JohnstonJ, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results.J Neurosurg45:622–627, 1976Schwetschenau PR, Ramirez A, Johnston J, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results. J Neurosurg 45:622–627, 1976
SchwetschenauPR, RamirezA, JohnstonJ, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results.J Neurosurg45:622–627, 1976Schwetschenau PR, Ramirez A, Johnston J, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results. J Neurosurg 45:622–627, 1976)| false
SmithL: Enzyme dissolution of the nucleus pulposus in humans.JAMA187:137–140, 1964Smith L: Enzyme dissolution of the nucleus pulposus in humans. JAMA 187:137–140, 1964
SmithL: Enzyme dissolution of the nucleus pulposus in humans.JAMA187:137–140, 1964Smith L: Enzyme dissolution of the nucleus pulposus in humans. JAMA 187:137–140, 1964)| false
SmithL, & BrownJE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain.J Bone Joint Surg (Br)49:502–519, 1967Smith L, Brown JE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg (Br) 49:502–519, 1967
SmithL, BrownJE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain.J Bone Joint Surg (Br)49:502–519, 1967Smith L, Brown JE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg (Br) 49:502–519, 1967)| false