Multiple cerebral hemorrhages following chymopapain chemonucleolysis

Case report

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  • 1 Departments of Neurosurgery and Radiology, The Johns Hopkins Hospital, Baltimore, Maryland
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✓ A case of multiple cerebral hemorrhages following chymopapain chemonucleolysis is reported. The authors believe the probable etiology was intrathecal extravasation of chymopapain after injection of the drug into a lumbar disc space.

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    Martins AN, , Ramirez A, & Johnston J, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results. J Neurosurg 49:816827, 1978 Martins AN, Ramirez A, Johnston J, et al: Double-blind evaluation of chemonucleolysis for herniated lumbar discs. Late results. J Neurosurg 49:816–827, 1978

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    Schwetschenau PR, , Ramirez A, & Johnston J, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results. J Neurosurg 45:622627, 1976 Schwetschenau PR, Ramirez A, Johnston J, et al: Double-blind evaluation of intradiscal chymopapain for herniated lumbar disc. Early results. J Neurosurg 45:622–627, 1976

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    Smith L, & Brown JE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg (Br) 49:502519, 1967 Smith L, Brown JE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg (Br) 49:502–519, 1967

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