Creatine kinase isoenzymes in severe head injury

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✓ Brain-type creatine kinase (CK) isoenzyme (CK-BB) was found in the ventricular cerebrospinal fluid (CSF) and the serum in a series of 35 patients within 13 hours following severe head injury. There was a good correlation between total CK and CK-BB activities in CSF only. The values found in the CSF appear to be a quantitative index of brain dysfunction at admission, and did not correlate with intracranial pressure activity. High levels of CK-BB in the CSF correlated with a poor outcome, and thus offer a reliable criterion for the assessment of the severity of head injury.

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Address reprint requests to: Pol Hans, M.D., Department of Anaesthesiology, University of Liège, Bavière Hospital, Boulevard de la Constitution, 66, B-4020, Liège, Belgium.
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