Cerebrospinal fluid drainage as influenced by ventricular pressure in the rabbit

J. Gordon McComb M.D.1, Hugh Davson D.Sc. (London)1, Shigeyo Hyman M.S.1, and Martin H. Weiss M.D.1
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  • 1 Division of Neurological Surgery, Childrens Hospital of Los Angeles, and University of Southern California School of Medicine, Los Angeles, California, and Department of Physiology, King's College, London, England
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✓ Artificial cerebrospinal fluid (CSF) containing radioisotope iodinated (125I) serum albumin (RISA) and either blue dextran or indigo carmine was given to white New Zealand rabbits over 4 hours. In one group it was given by ventriculocisternal perfusion, in one by ventricular infusion, and in one by cisterna magna infusion. Blood was sampled continuously from the superior sagittal sinus (SSS) or intermittently from the systemic arterial circulation. Removal of CSF from the cisterna magna during the ventriculocisternal perfusion kept the intracranial pressure (ICP) at 0 to 5 torr, whereas ventricular or cisterna magna infusion raised the ICP to 20 to 30 torr and 15 to 20 torr, respectively. In the two groups with raised ICP, an increased concentration of RISA was present in the optic nerves, olfactory bulbs, episcleral tissue, and deep cervical lymph nodes; but this was not found in the group with normal ICP. In all three groups, the concentration of RISA in the SSS blood was the same as in the systemic arterial blood. The concentration gradient of RISA across the cerebral cortex was similar in both the ventriculocisternal perfusion and the ventricular infusion groups. With cisterna magna infusion, the concentration of RISA was the same on the cortical surface and less in the ventricles compared with the ventricular infusion. It is concluded that, with elevated ICP, CSF drained via pathways that are less evident under normal pressure. Drainage of CSF was similar irrespective of whether the infusion site was the ventricles or cisterna magna. It did not appear that acute dilatation of the ventricles during ventricular infusion compromised the subarachnoid space over the surface of the hemisphere, as the concentration of RISA on the convexities and in the SSS blood did not significantly differ between the groups. Transcortical bulk transfer of CSF was not evident with raised ICP.

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Contributor Notes

Address reprint requests to: J. Gordon McComb, M.D., Division of Neurological Surgery, Childrens Hospital of Los Angeles, 4650 Sunset Boulevard, P. O. Box 54700, Los Angeles, California 90054.
  • 1.

    Arnold W, , Ritter R, & Wagner WH: Quantitative studies on the drainage of the cerebrospinal fluid into the lymphatic system. Acta Otolaryngol 76:156161, 1973 Arnold W, Ritter R, Wagner WH: Quantitative studies on the drainage of the cerebrospinal fluid into the lymphatic system. Acta Otolaryngol 76:156–161, 1973

    • Search Google Scholar
    • Export Citation
  • 2.

    Bering EA Jr, & Sato O: Hydrocephalus: changes in formation and absorption of cerebrospinal fluid within the cerebral ventricles. J Neurosurg 20:10501063, 1963 Bering EA Jr, Sato O: Hydrocephalus: changes in formation and absorption of cerebrospinal fluid within the cerebral ventricles. J Neurosurg 20:1050–1063, 1963

    • Search Google Scholar
    • Export Citation
  • 3.

    Bowsher D: Pathways of absorption of protein from the cerebrospinal fluid: an autoradiographic study in the cat. Anat Rec 128:2339, 1957 Bowsher D: Pathways of absorption of protein from the cerebrospinal fluid: an autoradiographic study in the cat. Anat Rec 128:23–39, 1957

    • Search Google Scholar
    • Export Citation
  • 4.

    Bradbury MWB: Proportion of cerebrospinal fluid draining into jugular lymphatic trunks of the cat. J Physiol (Lond) 276:67P68P, 1978 (Abstract) Bradbury MWB: Proportion of cerebrospinal fluid draining into jugular lymphatic trunks of the cat. J Physiol (Lond) 276:67P–68P, 1978 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 5.

    Bradbury MWB, & Cole DF: The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour. J Physiol (Lond) 299:353365, 1980 Bradbury MWB, Cole DF: The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour. J Physiol (Lond) 299:353–365, 1980

    • Search Google Scholar
    • Export Citation
  • 6.

    Brierley JB, & Field EJ: The connexions of the spinal subarachnoid space with the lymphatic system. J Anat 82:153166, 1948 Brierley JB, Field EJ: The connexions of the spinal subarachnoid space with the lymphatic system. J Anat 82:153–166, 1948

    • Search Google Scholar
    • Export Citation
  • 7.

    Butler AB: Personal communication, 1979 Butler AB: Personal communication, 1979

  • 8.

    Casley-Smith JR, , Földi-Börcsök E, & Földi M: The prelymphatic pathways of the brain as revealed by cervical lymphatic obstruction and the passage of particles. Br J Exp Pathol 57:179188, 1976 Casley-Smith JR, Földi-Börcsök E, Földi M: The prelymphatic pathways of the brain as revealed by cervical lymphatic obstruction and the passage of particles. Br J Exp Pathol 57:179–188, 1976

    • Search Google Scholar
    • Export Citation
  • 9.

    Clark WM: Topics in Physical Chemistry. Baltimore: Williams and Wilkins, 1948 Clark WM: Topics in Physical Chemistry. Baltimore: Williams and Wilkins, 1948

    • Search Google Scholar
    • Export Citation
  • 10.

    Courtice FC, & Simmonds WJ: The removal of protein from the subarachnoid space. Aust J Exp Biol Med Sci 29:255263, 1951 Courtice FC, Simmonds WJ: The removal of protein from the subarachnoid space. Aust J Exp Biol Med Sci 29:255–263, 1951

    • Search Google Scholar
    • Export Citation
  • 11.

    Crank J: Mathematics of Diffusion. London: Oxford University Press, 1956 Crank J: Mathematics of Diffusion. London: Oxford University Press, 1956

    • Search Google Scholar
    • Export Citation
  • 12.

    Davson H, , Domer FR, & Hollingsworth JR: The mechanism of drainage of the cerebrospinal fluid. Brain 96:329336, 1973 Davson H, Domer FR, Hollingsworth JR: The mechanism of drainage of the cerebrospinal fluid. Brain 96:329–336, 1973

    • Search Google Scholar
    • Export Citation
  • 13.

    DiChiro G, , Stein SC, & Harrington T: Spontaneous cerebrospinal fluid rhinorrhea in normal dogs. Radioisotope studies of an alternative pathway of CSF drainage. J Neuropathol Exp Neurol 31:447453, 1972 Di Chiro G, Stein SC, Harrington T: Spontaneous cerebrospinal fluid rhinorrhea in normal dogs. Radioisotope studies of an alternative pathway of CSF drainage. J Neuropathol Exp Neurol 31:447–453, 1972

    • Search Google Scholar
    • Export Citation
  • 14.

    Eisenberg HM, , McLennan JE, & Welch K: Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41:2028, 1974 Eisenberg HM, McLennan JE, Welch K: Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41:20–28, 1974

    • Search Google Scholar
    • Export Citation
  • 15.

    Field EJ, & Brierley JB: The retro-orbital tissues as a site of outflow of cerebrospinal fluid. Proc R Soc Lond 42:447450, 1949 Field EJ, Brierley JB: The retro-orbital tissues as a site of outflow of cerebrospinal fluid. Proc R Soc Lond 42:447–450, 1949

    • Search Google Scholar
    • Export Citation
  • 16.

    Földi M, , Csillik B, & Zoltan ÖT: Lymphatic drainage of the brain. Experientia 24:12831287, 1968 Földi M, Csillik B, Zoltan ÖT: Lymphatic drainage of the brain. Experientia 24:1283–1287, 1968

    • Search Google Scholar
    • Export Citation
  • 17.

    Jackson RT, , Tigges, J, & Arnold W: Subarachnoid space of the CNS, nasal mucosa and lymphatic system. Arch Otolaryngol 105:180184, 1979 Jackson RT, Tigges, J, Arnold W: Subarachnoid space of the CNS, nasal mucosa and lymphatic system. Arch Otolaryngol 105:180–184, 1979

    • Search Google Scholar
    • Export Citation
  • 18.

    James AE Jr, , McComb JG, & Christian J, et al. : The effect of cerebrospinal fluid pressure on the size of drainage pathways. Neurology 26:659663, 1976 James AE Jr, McComb JG, Christian J, et al: The effect of cerebrospinal fluid pressure on the size of drainage pathways. Neurology 26:659–663, 1976

    • Search Google Scholar
    • Export Citation
  • 19.

    James AE Jr, , Strecker EP, & Sperber E, et al. : An alternative pathway of cerebrospinal fluid absorption in communicating hydrocephalus. Transependymal movement. Radiology 111:143146, 1974 James AE Jr, Strecker EP, Sperber E, et al: An alternative pathway of cerebrospinal fluid absorption in communicating hydrocephalus. Transependymal movement. Radiology 111:143–146, 1974

    • Search Google Scholar
    • Export Citation
  • 20.

    Key EAH, & Retzius MG: Studien in der Anatomie des Nervensystems und des Bindegewebes. Stockholm: Samson and Wallin, 1875 Key EAH, Retzius MG: Studien in der Anatomie des Nervensystems und des Bindegewebes. Stockholm: Samson and Wallin, 1875

    • Search Google Scholar
    • Export Citation
  • 21.

    Mann JD, , Butler AB, & Johnson RN, et al. : Clearance of macromolecular and particulate substances from the cerebrospinal fluid system of the rat. J Neurosurg 50:343348, 1979 Mann JD, Butler AB, Johnson RN, et al: Clearance of macromolecular and particulate substances from the cerebrospinal fluid system of the rat. J Neurosurg 50:343–348, 1979

    • Search Google Scholar
    • Export Citation
  • 22.

    McComb JG, , Davson H, & Hollingsworth JR: Attempted separation of blood-brain and blood-cerebrospinal fluid barriers in the rabbit. Exp Eye Res 26 (Suppl): 333343, 1977 McComb JG, Davson H, Hollingsworth JR: Attempted separation of blood-brain and blood-cerebrospinal fluid barriers in the rabbit. Exp Eye Res 26 (Suppl):333–343, 1977

    • Search Google Scholar
    • Export Citation
  • 23.

    Milhorat TH, & Hammock MK: Isotope ventriculography. Interpretation of ventricular size and configuration in hydrocephalus. Arch Neurol 25:18, 1971 Milhorat TH, Hammock MK: Isotope ventriculography. Interpretation of ventricular size and configuration in hydrocephalus. Arch Neurol 25:1–8, 1971

    • Search Google Scholar
    • Export Citation
  • 24.

    Milhorat TH, , Hammock MK, & Di Chiro G: The subarachnoid space in congenital obstructive hydrocephalus. Part 1: Cisternographic findings. J Neurosurg 35:16, 1971 Milhorat TH, Hammock MK, Di Chiro G: The subarachnoid space in congenital obstructive hydrocephalus. Part 1: Cisternographic findings. J Neurosurg 35:1–6, 1971

    • Search Google Scholar
    • Export Citation
  • 25.

    Orosz Á , Földes I, & Kósa C, et al. : Radioactive isotope studies of the connection between the lymph circulation of the nasal mucosa, the cranial cavity and cerebrospinal fluid. Acta Physiol Hung 11:7581, 1957 Orosz Á Földes I, Kósa C, et al: Radioactive isotope studies of the connection between the lymph circulation of the nasal mucosa, the cranial cavity and cerebrospinal fluid. Acta Physiol Hung 11:75–81, 1957

    • Search Google Scholar
    • Export Citation
  • 26.

    Pollay M, & Davson H: The passage of certain substances out of the cerebrospinal fluid. Brain 86:137150, 1963 Pollay M, Davson H: The passage of certain substances out of the cerebrospinal fluid. Brain 86:137–150, 1963

    • Search Google Scholar
    • Export Citation
  • 27.

    Pollay M, , Stevens FA, & Welch J: Choroid plexus blood flow in rat and rabbit. Acta Neurol Scand 60 (Suppl 72): 596597, 1979 Pollay M, Stevens FA, Welch J: Choroid plexus blood flow in rat and rabbit. Acta Neurol Scand 60 (Suppl 72):596–597, 1979

    • Search Google Scholar
    • Export Citation
  • 28.

    Sahar A, , Hochwald GM, & Sadik AR, et al. : Cerebrospinal fluid absorption. In animals with experimental obstructive hydrocephalus. Arch Neurol 21:638644, 1969 Sahar A, Hochwald GM, Sadik AR, et al: Cerebrospinal fluid absorption. In animals with experimental obstructive hydrocephalus. Arch Neurol 21:638–644, 1969

    • Search Google Scholar
    • Export Citation
  • 29.

    Schurr PH, , McLaurin RL, & Ingraham FD: Experimental studies on the circulation of the cerebrospinal fluid, and methods of producing communicating hydrocephalus in the dog. J Neurosurg 10:515525, 1953 Schurr PH, McLaurin RL, Ingraham FD: Experimental studies on the circulation of the cerebrospinal fluid, and methods of producing communicating hydrocephalus in the dog. J Neurosurg 10:515–525, 1953

    • Search Google Scholar
    • Export Citation
  • 30.

    Schwalbe G: Der Arachnoidalraum ein Lymphraum und sein Zusammenhang mit den Perichoriodalraum. Zentralbl Med Wiss 7:465467, 1869 Schwalbe G: Der Arachnoidalraum ein Lymphraum und sein Zusammenhang mit den Perichoriodalraum. Zentralbl Med Wiss 7:465–467, 1869

    • Search Google Scholar
    • Export Citation
  • 31.

    Van Harreveld A, , Collewijn H, & Malhotra SK: Water, electrolytes, and extracellular space in hydrated and dehydrated brains. Am J Physiol 210:251256, 1966 Van Harreveld A, Collewijn H, Malhotra SK: Water, electrolytes, and extracellular space in hydrated and dehydrated brains. Am J Physiol 210:251–256, 1966

    • Search Google Scholar
    • Export Citation
  • 32.

    Weed LH: Studies on cerebro-spinal fluid. No. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J Med Res 31:5191, 1914 Weed LH: Studies on cerebro-spinal fluid. No. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J Med Res 31:51–91, 1914

    • Search Google Scholar
    • Export Citation
  • 33.

    Welch K: The principles of physiology of the cerebrospinal fluid in relation to hydrocephalus including normal pressure hydrocephalus, in Friedlander WJ (ed): Current Reviews. Advances in Neurology, Vol 13. New York: Raven Press, 1975, pp 247332 Welch K: The principles of physiology of the cerebrospinal fluid in relation to hydrocephalus including normal pressure hydrocephalus, in Friedlander WJ (ed): Current Reviews. Advances in Neurology, Vol 13. New York: Raven Press, 1975, pp 247–332

    • Search Google Scholar
    • Export Citation
  • 34.

    Wislocki GB, & Putnam TJ: Absorption from the ventricles in experimentally produced internal hydrocephalus. Am J Anat 29:313320, 1921 Wislocki GB, Putnam TJ: Absorption from the ventricles in experimentally produced internal hydrocephalus. Am J Anat 29:313–320, 1921

    • Search Google Scholar
    • Export Citation

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