✓ The energy-requiring cell functions in the brain are described. The role of specific inhibition of these functions, and their critical low-supply levels of blood flow and oxygen are reviewed in relation to clinical management of focal and complete global cerebral ischemia.
Adams JE, & Wylie EJ: Value of hypothermia and arterial occlusion in the treatment of intracranial aneurysms. Surg Gynecol Obstet 108:631–635, 1959 Adams JE, Wylie EJ: Value of hypothermia and arterial occlusion in the treatment of intracranial aneurysms. Surg Gynecol Obstet 108:631–635, 1959
Adolph EF: Regulations during survival without oxygen in infant mammals. Respir Physiol 7:356–368, 1969 Adolph EF: Regulations during survival without oxygen in infant mammals. Respir Physiol 7:356–368, 1969
Astrup J: Barbiturate protection in focal cerebral ischemia. Scand J Clin Lab Invest 40:201–203, 1980 (Editorial) Astrup J: Barbiturate protection in focal cerebral ischemia. Scand J Clin Lab Invest 40:201–203, 1980 (Editorial)
Astrup, J, , Blennow G, & Nilsson B: Effects of reduced cerebral blood flow upon EEG pattern, cerebral extracellular potassium, and energy metabolism in the rat cortex during bicuculline-induced seizures. Brain Res 177:115–126, 1979 Astrup, J, Blennow G, Nilsson B: Effects of reduced cerebral blood flow upon EEG pattern, cerebral extracellular potassium, and energy metabolism in the rat cortex during bicuculline-induced seizures. Brain Res 177:115–126, 1979
Astrup J, , Møller Sørensen |P|, & Rahbek Sørensen |H|: Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital, and lidocaine. Anesthesiology 55:263–268, 1981 Astrup J, Møller Sørensen P, Rahbek Sørensen H: Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital, and lidocaine. Anesthesiology 55:263–268, 1981
Astrup, J, , Møller Sørensen |P|, & Rahbek Sørensen H: Oxygen and glucose consumption related to Na+-K+ transport in the canine brain. Stroke 12:726–730, 1981 Astrup, J, Møller Sørensen P, Rahbek Sørensen H: Oxygen and glucose consumption related to Na+-K+ transport in the canine brain. Stroke 12:726–730, 1981
Astrup J, & Norberg K: Potassium activity in cerebral cortex in rats during progressive severe hypoglycemia. Brain Res 103:418–423, 1976 Astrup J, Norberg K: Potassium activity in cerebral cortex in rats during progressive severe hypoglycemia. Brain Res 103:418–423, 1976
Astrup J, , Rehncrona S, & Siesjö BK: The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate. Brain Res 199:161–174, 1980 Astrup J, Rehncrona S, Siesjö BK: The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate. Brain Res 199:161–174, 1980
Astrup J, , Siesjö BK, & Symon L: Thresholds in cerebral ischemia — the ischemic penumbra. Stroke 12:723–725, 1981 Astrup J, Siesjö BK, Symon L: Thresholds in cerebral ischemia — the ischemic penumbra. Stroke 12:723–725, 1981
Astrup J, , Skovsted P, & Gjerris F, et al: Increase in extracellular potassium in the brain during circulatory arrest: effects of hypothermia, lidocaine, and thiopental. Anesthesiology 55:256–262, 1981 Astrup J, Skovsted P, Gjerris F, et al: Increase in extracellular potassium in the brain during circulatory arrest: effects of hypothermia, lidocaine, and thiopental. Anesthesiology 55:256–262, 1981
Astrup J, , Symon L, & Branston NM, et al: Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 8:51–57, 1977 Astrup J, Symon L, Branston NM, et al: Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 8:51–57, 1977
Bachelard HS: Energy utilized by neurotransmitters, in Ingvar DH, & Lassen NA (eds): Brain Work. The Coupling of Function, Metabolism and Blood Flow in the Brain. Copenhagen: Munksgaard, 1975, pp 79–81 Bachelard HS: Energy utilized by neurotransmitters, in Ingvar DH, Lassen NA (eds): Brain Work. The Coupling of Function, Metabolism and Blood Flow in the Brain. Copenhagen: Munksgaard, 1975, pp 79–81
Barratt-Boyes BG, , Neutze JM, & Seelye ER, et al: Complete correction of cardiovascular malformations in the first year of life. Prog Cardiovasc Dis 15:229–253, 1972 Barratt-Boyes BG, Neutze JM, Seelye ER, et al: Complete correction of cardiovascular malformations in the first year of life. Prog Cardiovasc Dis 15:229–253, 1972
Behrendt DM: Deep hypothermia with circulatory arrest in infants, in Davila JD (ed): Second Henry Ford Hospital International Symposium on Cardiac Surgery. New York: Appleton-Century-Crofts, 1977, pp 119–124 Behrendt DM: Deep hypothermia with circulatory arrest in infants, in Davila JD (ed): Second Henry Ford Hospital International Symposium on Cardiac Surgery. New York: Appleton-Century-Crofts, 1977, pp 119–124
Belsey RHR, , Dowlatshahi K, & Keen G, et al: Profound hypothermia in cardiac surgery. J Thorac Cardiovasc Surg 56:497–509, 1968 Belsey RHR, Dowlatshahi K, Keen G, et al: Profound hypothermia in cardiac surgery. J Thorac Cardiovasc Surg 56:497–509, 1968
Benešová O, , Burešová O, & Bureš J: Die Wirkung des Chlorpromazins und der Glykämie auf das elektrophysiologisch kontrollierte Überleben der Hirnrinde bei verschiedenen Körpertemperaturen. Arch Exp Pathol Pharmakol 231:550–561, 1957 Benešová O, Burešová O, Bureš J: Die Wirkung des Chlorpromazins und der Glykämie auf das elektrophysiologisch kontrollierte Überleben der Hirnrinde bei verschiedenen Körpertemperaturen. Arch Exp Pathol Pharmakol 231:550–561, 1957
Bering EA Jr: Effect of body temperature change on cerebral oxygen consumption of the intact monkey. Am J Physiol 200:417–419, 1961 Bering EA Jr: Effect of body temperature change on cerebral oxygen consumption of the intact monkey. Am J Physiol 200:417–419, 1961
Bering EA Jr: Effects of profound hypothermia and circulatory arrset on cerebral oxygen metabolism and cerebrospinal fluid electrolyte composition in dogs. J Neurosurg 40:199–205, 1974 Bering EA Jr: Effects of profound hypothermia and circulatory arrset on cerebral oxygen metabolism and cerebrospinal fluid electrolyte composition in dogs. J Neurosurg 40:199–205, 1974
Bleyaert AL, , Nemoto EM, & Safar P, et al: Thiopental amelioration of brain damage after global ischemia in monkeys. Anesthesiology 49:390–398, 1978 Bleyaert AL, Nemoto EM, Safar P, et al: Thiopental amelioration of brain damage after global ischemia in monkeys. Anesthesiology 49:390–398, 1978
Branston NM, , Hope DT, & Symon L: Barbiturates in focal ischemia of primate cortex: effects on blood flow distribution, evoked potential and extracellular potassium. Stroke 10:647–653, 1979 Branston NM, Hope DT, Symon L: Barbiturates in focal ischemia of primate cortex: effects on blood flow distribution, evoked potential and extracellular potassium. Stroke 10:647–653, 1979
Branston NM, , Strong AJ, & Symon L: Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischemia in baboon cerebral cortex. J Neurol Sci 32:305–321, 1977 Branston NM, Strong AJ, Symon L: Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischemia in baboon cerebral cortex. J Neurol Sci 32:305–321, 1977
Branston NM, , Symon L, & Crockard HA, et al: Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 45:195–208, 1974 Branston NM, Symon L, Crockard HA, et al: Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 45:195–208, 1974
Brodersen P, & Jørgensen EO: Cerebral blood flow and oxygen uptake, and cerebrospinal fluid biochemistry in severe coma. J Neurol Neurosurg Psychiatry 37:384–391, 1974 Brodersen P, Jørgensen EO: Cerebral blood flow and oxygen uptake, and cerebrospinal fluid biochemistry in severe coma. J Neurol Neurosurg Psychiatry 37:384–391, 1974
Bureš J, & Burešová O: Die anoxische Terminaldepolarisation als Indicator der Vulnerabilität der Grosshirnrinde bei Anoxie und Ischämie. Pfluegers Arch 264:325–334, 1957 Bureš J, Burešová O: Die anoxische Terminaldepolarisation als Indicator der Vulnerabilität der Grosshirnrinde bei Anoxie und Ischämie. Pfluegers Arch 264:325–334, 1957
Butterfield JD Jr, & McGraw CP: Free radical pathology. Stroke 9:443–445, 1978 Butterfield JD Jr, McGraw CP: Free radical pathology. Stroke 9:443–445, 1978
Chapman AG, , Meldrum BS, & Siesjö BK: Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem 28:1025–1035, 1977 Chapman AG, Meldrum BS, Siesjö BK: Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem 28:1025–1035, 1977
Chater N, & Popp J: Microsurgical vascular bypass for occlusive cerebrovascular disease: review of 100 cases. Surg Neurol 6:115–118, 1976 Chater N, Popp J: Microsurgical vascular bypass for occlusive cerebrovascular disease: review of 100 cases. Surg Neurol 6:115–118, 1976
Christensen MS: Prolonged artificial hyperventilation in cerebral apoplexy. Acta Anaesthesiol Scand Suppl 62:7–24, 1976 Christensen MS: Prolonged artificial hyperventilation in cerebral apoplexy. Acta Anaesthesiol Scand Suppl 62:7–24, 1976
Cohen PJ: The metabolic function of oxygen and biochemical lesions of hypoxia. Anesthesiology 37:148–177, 1972 Cohen PJ: The metabolic function of oxygen and biochemical lesions of hypoxia. Anesthesiology 37:148–177, 1972
Cohen PJ, , Wollman H, & Alexander SC, et al: Cerebral carbohydrate metabolism in man during halothane anesthesia. Effects of PaCO2 on some aspects of carbohydrate utilization. Anesthesiology 25:185–191, 1964 Cohen PJ, Wollman H, Alexander SC, et al: Cerebral carbohydrate metabolism in man during halothane anesthesia. Effects of PaCO2 on some aspects of carbohydrate utilization. Anesthesiology 25:185–191, 1964
Collewijn H, & Schadé JP: Conductivity of the cerebral cortex after circulatory arrest at body temperatures from 37°C to 18°C. Arch Int Physiol Biochim 72:181–193, 1964 Collewijn H, Schadé JP: Conductivity of the cerebral cortex after circulatory arrest at body temperatures from 37°C to 18°C. Arch Int Physiol Biochim 72:181–193, 1964
Connolly JE, , Boyd RJ, & Calvin JW: The protective effect of hypothermia in cerebral ischemia; experimental and clinical application by selective brain cooling in the human. Surgery 52:15–24, 1962 Connolly JE, Boyd RJ, Calvin JW: The protective effect of hypothermia in cerebral ischemia; experimental and clinical application by selective brain cooling in the human. Surgery 52:15–24, 1962
Creutzfeldt OD: Neurophysiological correlates of different functional states of the brain, in Ingvar DH (eds): Brain Work. The Coupling of Function, Metabolism and Blood Flow in the Brain. Copenhagen: Munksgaard, 1975, pp 21–46 Creutzfeldt OD: Neurophysiological correlates of different functional states of the brain, in Ingvar DH, Lassen NA (eds): Brain Work. The Coupling of Function, Metabolism and Blood Flow in the Brain. Copenhagen: Munksgaard, 1975, pp 21–46
Dillard DH, , Mohri H, & Merendino KA: Correction of heart disease in infancy utilizing deep hypothermia and total circulatory arrest. J Thorac Cardiovasc Surg 61:64–69, 1971 Dillard DH, Mohri H, Merendino KA: Correction of heart disease in infancy utilizing deep hypothermia and total circulatory arrest. J Thorac Cardiovasc Surg 61:64–69, 1971
Fieschi C: Cerebral blood flow and energy metabolism in vascular insufficiency. Stroke 11:431–432, 1980 (Editorial) Fieschi C: Cerebral blood flow and energy metabolism in vascular insufficiency. Stroke 11:431–432, 1980 (Editorial)
Flamm ES, , Demopoulos HB, & Seligman ML, et al: Free radicals in cerebral ischemia. Stroke 9:445–447, 1978 Flamm ES, Demopoulos HB, Seligman ML, et al: Free radicals in cerebral ischemia. Stroke 9:445–447, 1978
Gatfield PD, , Lowry OH, & Schultz DW, et al: Regional energy reserves in mouse brain and changes with ischaemia and anaesthesia. J Neurochem 13:185–195, 1966 Gatfield PD, Lowry OH, Schultz DW, et al: Regional energy reserves in mouse brain and changes with ischaemia and anaesthesia. J Neurochem 13:185–195, 1966
Ginsberg MD, , Budd WW, & Welsh FA: Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation. Ann Neurol 3:482–492, 1978 Ginsberg MD, Budd WW, Welsh FA: Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation. Ann Neurol 3:482–492, 1978
Goodlin RC: Drug protection for fetal anoxia. Obstet Gynecol 26:9–13, 1965 Goodlin RC: Drug protection for fetal anoxia. Obstet Gynecol 26:9–13, 1965
Gordh T: Kliniska erfarenheter med Xylocain—ett nytt lokalanestheticum. Svenska Läk Tidn 45:117–123, 1948 Gordh T: Kliniska erfarenheter med Xylocain—ett nytt lokalanestheticum. Svenska Läk Tidn 45:117–123, 1948
Gottstein U, , Bernsmeier A, & Lehn H, et al: [Hemodynamics and metabolism of the brain in hypnotic poisoning.] Dtsch Med Wochenschr 86:2170–2176, 1961 (Ger) Gottstein U, Bernsmeier A, Lehn H, et al: [Hemodynamics and metabolism of the brain in hypnotic poisoning.] Dtsch Med Wochenschr 86:2170–2176, 1961 (Ger)
Gratzl O, , Schmiedek P, & Spetzler R, et al: Clinical experience with extra-intracranial arterial anastomosis in 65 cases. J Neurosurg 44:313–324, 1976 Gratzl O, Schmiedek P, Spetzler R, et al: Clinical experience with extra-intracranial arterial anastomosis in 65 cases. J Neurosurg 44:313–324, 1976
Hägerdal M, , Harp J, & Nilsson L, et al: The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 24:311–316, 1975 Hägerdal M, Harp J, Nilsson L, et al: The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 24:311–316, 1975
Hansen AJ: The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats. Acta Physiol Scand 102:324–329, 1978 Hansen AJ: The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats. Acta Physiol Scand 102:324–329, 1978
Hansen AJ: Extracellular potassium concentration in juvenile and adult rat brain cortex during anoxia. Acta Physiol Scand 99:412–420, 1977 Hansen AJ: Extracellular potassium concentration in juvenile and adult rat brain cortex during anoxia. Acta Physiol Scand 99:412–420, 1977
Hansen AJ, & Nordström CH: Brain extracellular potassium and energy metabolism during ischemia in juvenile rats after exposure to hypoxia for 24 h. J Neurochem 32:915–920, 1979 Hansen AJ, Nordström CH: Brain extracellular potassium and energy metabolism during ischemia in juvenile rats after exposure to hypoxia for 24 h. J Neurochem 32:915–920, 1979
Heiss WD, , Hayakawa T, & Waltz AG: Cortical neuronal function during ischemia. Effects of occlusion of one middle cerebral artery on single-unit activity in cats. Arch Neurol 33:813–820, 1976 Heiss WD, Hayakawa T, Waltz AG: Cortical neuronal function during ischemia. Effects of occlusion of one middle cerebral artery on single-unit activity in cats. Arch Neurol 33:813–820, 1976
Himwich HE, , Bernstein AO, & Herrlich H, et al: Mechanisms for the maintenance of life in the newborn during anoxia. Am J Physiol 135:387–391, 1942 Himwich HE, Bernstein AO, Herrlich H, et al: Mechanisms for the maintenance of life in the newborn during anoxia. Am J Physiol 135:387–391, 1942
Himwich WA, , Homburger E, & Maresca R, et al: Brain metabolism in man: unanesthetized and in pentothal narcosis. Am J Psychiatry 103:689–696, 1947 Himwich WA, Homburger E, Maresca R, et al: Brain metabolism in man: unanesthetized and in pentothal narcosis. Am J Psychiatry 103:689–696, 1947
Hossman KA: Total ischemia of the brain, in Zulch KJ, , Kaufmann W, & Hossmann KA, et al (eds): Brain and Heart Infarct: Proceedings. Cologne Symposium, Third, June 16–19, 1976. Berlin/Heidelberg/New York: Springer-Verlag, 1977, pp 107–122 Hossman KA: Total ischemia of the brain, in Zulch KJ, Kaufmann W, Hossmann KA, et al (eds): Brain and Heart Infarct: Proceedings. Cologne Symposium, Third, June 16–19, 1976. Berlin/Heidelberg/New York: Springer-Verlag, 1977, pp 107–122
Hossmann KA, & Kleihues P: Reversibility of ischemic brain damage. Arch Neurol 29:375–384, 1973 Hossmann KA, Kleihues P: Reversibility of ischemic brain damage. Arch Neurol 29:375–384, 1973
Hossmann KA, , Sakaki S, & Zimmermann V: Cation activities in reversible ischemia of the cat brain. Stroke 8:77–81, 1977 Hossmann KA, Sakaki S, Zimmermann V: Cation activities in reversible ischemia of the cat brain. Stroke 8:77–81, 1977
Kety SS: Circulation and metabolism of the human brain in health and disease. Am J Med 8:205–217, 1950 Kety SS: Circulation and metabolism of the human brain in health and disease. Am J Med 8:205–217, 1950
Kety SS, & Schmidt CF: The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27:476–483, 1948 Kety SS, Schmidt CF: The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27:476–483, 1948
Kety SS, , Woodford RB, & Harmel MH, et al: Cerebral blood flow and metabolism in schizophrenia. The effects of barbiturate semi-narcosis, insulin coma and electroshock. Am J Psychiatry 104:765–770, 1948 Kety SS, Woodford RB, Harmel MH, et al: Cerebral blood flow and metabolism in schizophrenia. The effects of barbiturate semi-narcosis, insulin coma and electroshock. Am J Psychiatry 104:765–770, 1948
Kleihues P, , Hossmann KA, & Pegg AE, et al: Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery. Brain Res 95:61–73, 1975 Kleihues P, Hossmann KA, Pegg AE, et al: Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery. Brain Res 95:61–73, 1975
Kramer RS, , Sanders AP, & Lesage AM, et al: The effect of profound hypothermia on preservation of cerebral ATP content during circulatory arrest. J Thorac Cardiovasc Surg 56:699–709, 1968 Kramer RS, Sanders AP, Lesage AM, et al: The effect of profound hypothermia on preservation of cerebral ATP content during circulatory arrest. J Thorac Cardiovasc Surg 56:699–709, 1968
Křivánek J, , Bureš J, & Burešová O: The relationship between the level of certain brain metabolites and the degree of cortical polarity following temporary ischaemia of the brain in rats. Physiol Bohemoslov 8:195–201, 1959 Křivánek J, Bureš J, Burešová O: The relationship between the level of certain brain metabolites and the degree of cortical polarity following temporary ischaemia of the brain in rats. Physiol Bohemoslov 8:195–201, 1959
Lafferty JJ, , Keykhah MM, & Shapiro HM, et al: Cerebral hypometabolism obtained with deep pentobarbital anesthesia and hypothermia (30 C). Anesthesiology 49:159–164, 1978 Lafferty JJ, Keykhah MM, Shapiro HM, et al: Cerebral hypometabolism obtained with deep pentobarbital anesthesia and hypothermia (30 C). Anesthesiology 49:159–164, 1978
Lassen NA: Cerebral blood flow and oxygen consumption in man. Physiol Rev 39:183–238, 1959 Lassen NA: Cerebral blood flow and oxygen consumption in man. Physiol Rev 39:183–238, 1959
Lassen NA, , Ingvar DH, & Skinhøj E: Brain function and blood flow. Sci Am 239 (4): 62–71, 1978 Lassen NA, Ingvar DH, Skinhøj E: Brain function and blood flow. Sci Am 239 (4):62–71, 1978
Lewis DV, & Schuette WH: NADH fluorescence, [K+]o and oxygen consumption in cat cerebral cortex during direct cortical stimulation. Brain Res 110:523–535, 1976 Lewis DV, Schuette WH: NADH fluorescence, [K+]o and oxygen consumption in cat cerebral cortex during direct cortical stimulation. Brain Res 110:523–535, 1976
Lewis LD, , Ljunggren B, & Ratcheson RA, et al: Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and to EEG. J Neurochem 23:673–679, 1974 Lewis LD, Ljunggren B, Ratcheson RA, et al: Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and to EEG. J Neurochem 23:673–679, 1974
Ljunggren B, , Norberg K, & Siesjö BK: Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia. Brain Res 77:173–186, 1974 Ljunggren B, Norberg K, Siesjö BK: Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia. Brain Res 77:173–186, 1974
Ljunggren B, , Ratcheson RA, & Siesjö BK: Cerebral metabolic state following complete compression ischemia. Brain Res 73:291–307, 1974 Ljunggren B, Ratcheson RA, Siesjö BK: Cerebral metabolic state following complete compression ischemia. Brain Res 73:291–307, 1974
Ljunggren B, , Schutz H, & Siesjö BK: Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia. Brain Res 73:277–289, 1974 Ljunggren B, Schutz H, Siesjö BK: Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia. Brain Res 73:277–289, 1974
Marshall LF, , Durity F, & Lounsbury R, et al: Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier and neurological function. J Neurosurg 43:308–317, 1975 Marshall LF, Durity F, Lounsbury R, et al: Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier and neurological function. J Neurosurg 43:308–317, 1975
Marshall LF, , Welsh F, & Durity F, et al: Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 3: Brain energy metabolism. J Neurosurg 43:323–328, 1975 Marshall LF, Welsh F, Durity F, et al: Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 3: Brain energy metabolism. J Neurosurg 43:323–328, 1975
Meldrum BS, & Nilsson B: Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain 99:523–542, 1976 Meldrum BS, Nilsson B: Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain 99:523–542, 1976
Michenfelder JD: The interdependency of cerebral function and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 41:231–236, 1974 Michenfelder JD: The interdependency of cerebral function and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 41:231–236, 1974
Michenfelder JD, & Milde JH: Cerebral protection by anaesthetics during ischaemia (a review). Resuscitation 4:219–233, 1975 Michenfelder JD, Milde JH: Cerebral protection by anaesthetics during ischaemia (a review). Resuscitation 4:219–233, 1975
Michenfelder JD, & Theye RA: The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 33:430–439, 1970 Michenfelder JD, Theye RA: The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 33:430–439, 1970
Michenfelder JD, & Theye RA: Hypothermia: effect of canine brain and whole-body metabolism. Anesthesiology 29:1107–1112, 1968 Michenfelder JD, Theye RA: Hypothermia: effect of canine brain and whole-body metabolism. Anesthesiology 29:1107–1112, 1968
Morawetz RB, , Crowell RH, & DeGirolami U, et al: Regional cerebral blood flow thresholds during cerebral ischemia. Fed Proc 38:2493–2494, 1979 Morawetz RB, Crowell RH, DeGirolami U, et al: Regional cerebral blood flow thresholds during cerebral ischemia. Fed Proc 38:2493–2494, 1979
Morawetz RB, , DeGirolami U, & Ojemann RG, et al: Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke 9:143–149, 1978 Morawetz RB, DeGirolami U, Ojemann RG, et al: Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke 9:143–149, 1978
Morawetz RB, , Marcoux FW, & Crowell RM, et al: Identical thresholds for cerebral ischemia in white and gray matter. Acta Neurol Scand 60 (Suppl 72): 282–283, 1979 Morawetz RB, Marcoux FW, Crowell RM, et al: Identical thresholds for cerebral ischemia in white and gray matter. Acta Neurol Scand 60 (Suppl 72):282–283, 1979
Munson ES, , Techer WK, & Ausinsch B, et al: Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Anesthesiology 42:471–478, 1975 Munson ES, Techer WK, Ausinsch B, et al: Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Anesthesiology 42:471–478, 1975
Myers RE, & Yamaguchi S: Nervous system effects of cardiac arrest in monkeys. Preservation of vision. Arch Neurol 34:65–74, 1977 Myers RE, Yamaguchi S: Nervous system effects of cardiac arrest in monkeys. Preservation of vision. Arch Neurol 34:65–74, 1977
Nemoto EM: Pathogenesis of cerebral ischemiaanoxia. Crit Care Med 6:203–214, 1978 Nemoto EM: Pathogenesis of cerebral ischemiaanoxia. Crit Care Med 6:203–214, 1978
Nicholson D, , ten Bruggencate |G|, & Steinberg R, et al: Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci USA 74:1287–1290, 1977 Nicholson D, ten Bruggencate G, Steinberg R, et al: Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci USA 74:1287–1290, 1977
Nilsson L, & Siesjö BK: The effect of phenobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand Suppl 57:18–24, 1975 Nilsson L, Siesjö BK: The effect of phenobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand Suppl 57:18–24, 1975
Norberg K, & Siesjö BK: Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia. J Neurochem 26:345–352, 1976 Norberg K, Siesjö BK: Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia. J Neurochem 26:345–352, 1976
Nordström CH, & Rehncrona S: Reduction of cerebral blood flow and oxygen consumption with a combination of barbiturate anaesthesia and induced hypothermia in the rat. Acta Anaesthesiol Scand 22:7–12, 1978 Nordström CH, Rehncrona S: Reduction of cerebral blood flow and oxygen consumption with a combination of barbiturate anaesthesia and induced hypothermia in the rat. Acta Anaesthesiol Scand 22:7–12, 1978
Nordström CH, , Rehncrona S, & Siesjö BK: Effects of phenobarbital on cerebral ischemia. Part II: Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after pronounced incomplete ischemia. Stroke 9:335–343, 1978 Nordström CH, Rehncrona S, Siesjö BK: Effects of phenobarbital on cerebral ischemia. Part II: Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after pronounced incomplete ischemia. Stroke 9:335–343, 1978
Nordström CH, & Siesjö BK: Influence of phenobarbital on changes in the metabolites of the energy reserve of the cerebral cortex following complete ischemia. Acta Physiol Scand 104:271–280, 1978 Nordström CH, Siesjö BK: Influence of phenobarbital on changes in the metabolites of the energy reserve of the cerebral cortex following complete ischemia. Acta Physiol Scand 104:271–280, 1978
Patterson RH Jr, , McSherry CK, & Schwartz MS: Hyperbaric oxygen, hypothermia, and cerebral ischemia in the dog. J Surg Res 8:279–285, 1968 Patterson RH Jr, McSherry CK, Schwartz MS: Hyperbaric oxygen, hypothermia, and cerebral ischemia in the dog. J Surg Res 8:279–285, 1968
Phelps ME, , Huang SC, & Hoffman EJ, et al: Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 6:371–388, 1979 Phelps ME, Huang SC, Hoffman EJ, et al: Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 6:371–388, 1979
Pierce EC Jr, , Lambertsen CJ, & Deutsch S, et al: Cerebral circulation and metabolism during thiopental anesthesia and hyperventilation in man. J Clin Invest 41:1664–1671, 1962 Pierce EC Jr, Lambertsen CJ, Deutsch S, et al: Cerebral circulation and metabolism during thiopental anesthesia and hyperventilation in man. J Clin Invest 41:1664–1671, 1962
Ping FC, & Jenkins LC: Protection of the brain from hypoxia: a review. Can Anaesth Soc J 25:468–473, 1978 Ping FC, Jenkins LC: Protection of the brain from hypoxia: a review. Can Anaesth Soc J 25:468–473, 1978
Pulsinelli W, , Waldman S, & Sigsbee B, et al: Experimental hyperglycemia and diabetes mellitus worsen stroke outcome, in Betz E, , Grote J, & Heuser D, et al (eds): Pathophysiology and Pharmacology of Cerebrovascular Disorders. Baden-Baden/Köln/New York: Gerhard Witzstrock, 1980, pp 196–199 Pulsinelli W, Waldman S, Sigsbee B, et al: Experimental hyperglycemia and diabetes mellitus worsen stroke outcome, in Betz E, Grote J, Heuser D, et al (eds): Pathophysiology and Pharmacology of Cerebrovascular Disorders. Baden-Baden/Köln/New York: Gerhard Witzstrock, 1980, pp 196–199
Rehncrona S, , Rosén I, & Siesjö BK: Excessive cellular acidosis: an important mechanism of neuronal damage in the brain? Acta Physiol Scand 110:435–437, 1980 Rehncrona S, Rosén I, Siesjö BK: Excessive cellular acidosis: an important mechanism of neuronal damage in the brain? Acta Physiol Scand 110:435–437, 1980
Renck H: Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 40:209–210, 1980 (Editorial) Renck H: Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 40:209–210, 1980 (Editorial)
Rockoff MA, & Shapiro HM: Barbiturates following cardiac arrest: possible benefit or Pandora's box? Anesthesiology 49:385–387, 1978 (Editorial) Rockoff MA, Shapiro HM: Barbiturates following cardiac arrest: possible benefit or Pandora's box? Anesthesiology 49:385–387, 1978 (Editorial)
Rosomoff HL: Hypothermia and cerebral vascular lesions. I. Experimental interruption of the middle cerebral artery during hypothermia. J Neurosurg 13:332–343, 1956 Rosomoff HL: Hypothermia and cerebral vascular lesions. I. Experimental interruption of the middle cerebral artery during hypothermia. J Neurosurg 13:332–343, 1956
Rosomoff HL, & Holaday DA: Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol 179:85–88, 1954 Rosomoff HL, Holaday DA: Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol 179:85–88, 1954
Safar P: Amelioration of post-ischemic brain damage with barbiturates. Stroke 11:565–568, 1980 Safar P: Amelioration of post-ischemic brain damage with barbiturates. Stroke 11:565–568, 1980
Sakabe T, , Maekawa T, & Ishikawa T, et al: The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram. Anesthesiology 40:433–441, 1974 Sakabe T, Maekawa T, Ishikawa T, et al: The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram. Anesthesiology 40:433–441, 1974
Samsom FE Jr, , Balfour WM, & Dahl NA: Cerebral free energy and viability: ATP in rats under nitrogen and iodoacetate with the effects of temperature. Am J Physiol 196:325–326, 1959 Samsom FE Jr, Balfour WM, Dahl NA: Cerebral free energy and viability: ATP in rats under nitrogen and iodoacetate with the effects of temperature. Am J Physiol 196:325–326, 1959
Samson FE Jr, , Balfour WM, & Dahl NA: Rate of cerebral ATP utilization in rats. Am J Physiol 198:213–216, 1960 Samson FE Jr, Balfour WM, Dahl NA: Rate of cerebral ATP utilization in rats. Am J Physiol 198:213–216, 1960
Selle WA: Influence of glucose on the gasping pattern of young animals subjected to acute anoxia. Am J Physiol 141:297–302, 1944 Selle WA: Influence of glucose on the gasping pattern of young animals subjected to acute anoxia. Am J Physiol 141:297–302, 1944
Sharbrough FW, , Messick JM Jr, & Sundt TM Jr: Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid end-arterectomy. Stroke 4:674–683, 1973 Sharbrough FW, Messick JM Jr, Sundt TM Jr: Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid end-arterectomy. Stroke 4:674–683, 1973
Siemkowicz E, & Hansen AJ: Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats. Stroke 12:236–240, 1981 Siemkowicz E, Hansen AJ: Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats. Stroke 12:236–240, 1981
Siemkowicz E, & Hansen AJ: Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats. Acta Neurol Scand 58:1–8, 1978 Siemkowicz E, Hansen AJ: Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats. Acta Neurol Scand 58:1–8, 1978
Siesjö BK: Brain Energy Metabolism. New York/Brisbane/Toronto: John Wiley and Sons, 1978, 607 pp Siesjö BK: Brain Energy Metabolism. New York/Brisbane/Toronto: John Wiley and Sons, 1978, 607 pp
Skinhøj E, & Paulson OB: The mechanism of action of aminophylline upon cerebral vascular disorders. Acta Neurol Scand 46:129–140, 1970 Skinhøj E, Paulson OB: The mechanism of action of aminophylline upon cerebral vascular disorders. Acta Neurol Scand 46:129–140, 1970
Smith AL: Barbiturate protection in cerebral hypoxia. Anesthesiology 47:285–293, 1977 Smith AL: Barbiturate protection in cerebral hypoxia. Anesthesiology 47:285–293, 1977
Smith AL, , Hoff JT, & Nielsen SL, et al: Barbiturate protection in acute focal cerebral ischemia. Stroke 5:1–7, 1974 Smith AL, Hoff JT, Nielsen SL, et al: Barbiturate protection in acute focal cerebral ischemia. Stroke 5:1–7, 1974
Smith DS, , Rehncrona S, & Siesjö BK: Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro: comparison with the effects of promethazine and chlorpromazine. Anesthesiology 53:186–194, 1980 Smith DS, Rehncrona S, Siesjö BK: Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro: comparison with the effects of promethazine and chlorpromazine. Anesthesiology 53:186–194, 1980
Smith MC, , Adams JE, & Leake TB, et al: Occlusion of the blood supply to the brain of the goat. Protective effect of deep hypothermia. J Neurosurg 20:46–59, 1963 Smith MC, Adams JE, Leake TB, et al: Occlusion of the blood supply to the brain of the goat. Protective effect of deep hypothermia. J Neurosurg 20:46–59, 1963
Snyder BD, , Ramirez-Lassepas M, & Sukhum P, et al: Failure of thiopental to modify global anoxic injury. Stroke 10:135–141, 1979 Snyder BD, Ramirez-Lassepas M, Sukhum P, et al: Failure of thiopental to modify global anoxic injury. Stroke 10:135–141, 1979
Sokoloff L: Circulation and energy metabolism of the brain, in Albers RW, , Siegel GJ, & Katzman R, et al (eds): Basic Neurochemistry. Boston: Little, Brown and Co, 1972, pp 299–325 Sokoloff L: Circulation and energy metabolism of the brain, in Albers RW, Siegel GJ, Katzman R, et al (eds): Basic Neurochemistry. Boston: Little, Brown and Co, 1972, pp 299–325
Sokoloff L: Localization of functional activity in the central nervous system by measurements of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1:7–36, 1981 Sokoloff L: Localization of functional activity in the central nervous system by measurements of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1:7–36, 1981
Soloway M, , Nadel W, & Albin MS, et al: The effect of hyperventilation on subsequent cerebral infarction. Anesthesiology 29:975–980, 1968 Soloway M, Nadel W, Albin MS, et al: The effect of hyperventilation on subsequent cerebral infarction. Anesthesiology 29:975–980, 1968
Steen PA: Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 40:205–207, 1980 (Editorial) Steen PA: Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 40:205–207, 1980 (Editorial)
Steen PA, & Michenfelder JD: Mechanisms of barbiturate protection. Anesthesiology 53:183–185, 1980 (Editorial) Steen PA, Michenfelder JD: Mechanisms of barbiturate protection. Anesthesiology 53:183–185, 1980 (Editorial)
Steen PA, , Michenfelder JD, & Milde JH: Incomplete versus complete cerebral ischemia: improved outcome with a minimal blood flow. Ann Neurol 6:389–398, 1979 Steen PA, Michenfelder JD, Milde JH: Incomplete versus complete cerebral ischemia: improved outcome with a minimal blood flow. Ann Neurol 6:389–398, 1979
Steen PA, , Milde JH, & Michenfelder JD: No barbiturate protection in a dog model of complete cerebral ischemia. Ann Neurol 5:343–349, 1979 Steen PA, Milde JH, Michenfelder JD: No barbiturate protection in a dog model of complete cerebral ischemia. Ann Neurol 5:343–349, 1979
Stone HH, , Donnelly C, & Frobese AS: The effect of lowered body temperature on the cerebral hemodynamics and metabolism of man. Surg Gynecol Obstet 103:313–317, 1956 Stone HH, Donnelly C, Frobese AS: The effect of lowered body temperature on the cerebral hemodynamics and metabolism of man. Surg Gynecol Obstet 103:313–317, 1956
Strichartz G: Molecular mechanisms of nerve block by local anesthetics. Anesthesiology 45:421–441, 1976 Strichartz G: Molecular mechanisms of nerve block by local anesthetics. Anesthesiology 45:421–441, 1976
Symon L, & Brierly JB: Morphological changes in cerebral blood vessels in chronic ischemic infarction: flow correlation obtained by the hydrogen clearance method, in Cérvos-Navarro J, , Betz E, & Matakas F, et al (eds): The Cerebral Vessel Wall. New York: Raven Press, 1976, pp 165–174 Symon L, Brierly JB: Morphological changes in cerebral blood vessels in chronic ischemic infarction: flow correlation obtained by the hydrogen clearance method, in Cérvos-Navarro J, Betz E, Matakas F, et al (eds): The Cerebral Vessel Wall. New York: Raven Press, 1976, pp 165–174
Symon L, , Crockard HA, & Dorsch NWC, et al: Local cerebral blood flow and vascular reactivity in a chronic stable stroke in baboons. Stroke 6:482–492, 1975 Symon L, Crockard HA, Dorsch NWC, et al: Local cerebral blood flow and vascular reactivity in a chronic stable stroke in baboons. Stroke 6:482–492, 1975
Symon L, , Pasztor E, & Branston NM: The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons. Stroke 5:355–364, 1974 Symon L, Pasztor E, Branston NM: The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons. Stroke 5:355–364, 1974
Tamura A, , Asano T, & Sano K: Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion. Stroke 11:487–493, 1980 Tamura A, Asano T, Sano K: Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion. Stroke 11:487–493, 1980
Thorn W, , Scholl H, & Pfleiderer G, et al: [Metabolic processes in the brain at normal and reduced temperatures and under anoxic and ischaemic conditions.] J Neurochem 2:150–165, 1958 (Ger) Thorn W, Scholl H, Pfleiderer G, et al: [Metabolic processes in the brain at normal and reduced temperatures and under anoxic and ischaemic conditions.] J Neurochem 2:150–165, 1958 (Ger)
Thurston JH, & McDougal DB Jr: Effect of ischemia on metabolism of the brain of the newborn mouse. Am J Physiol 216:348–352, 1969 Thurston JH, McDougal DB Jr: Effect of ischemia on metabolism of the brain of the newborn mouse. Am J Physiol 216:348–352, 1969
Trojaborg W, & Boysen G: Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy. Electroencephalogr Clin Neurophysiol 34:61–69, 1973 Trojaborg W, Boysen G: Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy. Electroencephalogr Clin Neurophysiol 34:61–69, 1973
van Harreveld |A|: The extracellular space in the vertebrate central nervous system, in Bourne GH (ed): The Structure and Function of Nervous Tissue. New York/London: Academic Press, 1972, Vol IV, pp 447–511 van Harreveld A: The extracellular space in the vertebrate central nervous system, in Bourne GH (ed): The Structure and Function of Nervous Tissue. New York/London: Academic Press, 1972, Vol IV, pp 447–511
van Harreveld |A|, & Ochs S: Cerebral impedance changes after circulatory arrest. Am J Physiol 187:180–192, 1956 van Harreveld A, Ochs S: Cerebral impedance changes after circulatory arrest. Am J Physiol 187:180–192, 1956
Vern BA, , Schuette WH, & Mutsuga N, et al: Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures. Epilepsia 20:711–724, 1979 Vern BA, Schuette WH, Mutsuga N, et al: Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures. Epilepsia 20:711–724, 1979
Vyskočil F, , Kříž N, & Bureš J: Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res 39:255–259, 1972 Vyskočil F, Kříž N, Bureš J: Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res 39:255–259, 1972
Wechsler RL, , Dripps RD, & Kety SS: Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental. Anesthesiology 12:308–314, 1951 Wechsler RL, Dripps RD, Kety SS: Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental. Anesthesiology 12:308–314, 1951
Whittam R: The dependence of the respiration of brain cortex on active cation transport. Biochem J 82:205–212, 1962 Whittam R: The dependence of the respiration of brain cortex on active cation transport. Biochem J 82:205–212, 1962
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