The value of decompression for acute experimental spinal cord compression injury

Eugen J. Dolan M.D., B.Sc.1, Charles H. Tator M.D., Ph.D., F.R.C.S.(C)1, and Laszlo Endrenyi Ph.D.1
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  • 1 Division of Neurosurgery, Sunnybrook Medical Centre, and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
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✓ A clip compression method was used to produce acute spinal cord compression injury in rats. The force and duration of the spinal cord compression were independently varied, and functional recovery of the cord was assessed using the inclined plane technique. Mathematical modeling produced a curve defining the relationship between force, duration, and functional recovery for each week after injury. The study clearly showed the beneficial effect of decompression and that increasing either the force or duration of compression, or both, caused a reduction in recovery.

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  • 1.

    Dohrmann GJ, , Panjabi MM, & Banks D: Biomechanics of experimental spinal cord trauma. J Neurosurg 48:9931001, 1978 Dohrmann GJ, Panjabi MM, Banks D: Biomechanics of experimental spinal cord trauma. J Neurosurg 48:993–1001, 1978

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  • 2.

    Dolan EJ, & Tator CH: A new method for testing the force of clips for aneurysms or experimental spinal cord compression. J Neurosurg 51:229233, 1979 Dolan EJ, Tator CH: A new method for testing the force of clips for aneurysms or experimental spinal cord compression. J Neurosurg 51:229–233, 1979

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    • Export Citation
  • 3.

    Ducker TB, , Salcman M, & Daniell HB: Experimental spinal cord trauma, III: Therapeutic effect of immobilization and pharmacologic agents. Surg Neurol 10:7176, 1978 Ducker TB, Salcman M, Daniell HB: Experimental spinal cord trauma, III: Therapeutic effect of immobilization and pharmacologic agents. Surg Neurol 10:71–76, 1978

    • Search Google Scholar
    • Export Citation
  • 4.

    Endrenyi L: Dose-response relationships, in Seeman P, & Sellers EM (eds): Principles of Medical Pharmacology. Toronto: University of Toronto Press, 1970, pp3339 Endrenyi L: Dose-response relationships, in Seeman P, Sellers EM (eds): Principles of Medical Pharmacology. Toronto: University of Toronto Press, 1970, pp 33–39

    • Search Google Scholar
    • Export Citation
  • 5.

    Koenig G, & Dohrmann GJ: Histopathological variability in “standardised” spinal cord trauma. J Neurol Neurosurg Psychiatry 40:12031210, 1977 Koenig G, Dohrmann GJ: Histopathological variability in “standardised” spinal cord trauma. J Neurol Neurosurg Psychiatry 40:1203–1210, 1977

    • Search Google Scholar
    • Export Citation
  • 6.

    Rivlin AS, & Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:3943, 1978 Rivlin AS, Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:39–43, 1978

    • Search Google Scholar
    • Export Citation
  • 7.

    Rivlin AS, & Tator CH: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47:577581, 1977 Rivlin AS, Tator CH: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47:577–581, 1977

    • Search Google Scholar
    • Export Citation
  • 8.

    Tarlov IM: Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs. Arch Neurol Psychiatry 71:588597, 1954 Tarlov IM: Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs. Arch Neurol Psychiatry 71:588–597, 1954

    • Search Google Scholar
    • Export Citation
  • 9.

    Tarlov IM, & Klinger H: Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. Arch Neurol Psychiatry 71:271290, 1954 Tarlov IM, Klinger H: Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. Arch Neurol Psychiatry 71:271–290, 1954

    • Search Google Scholar
    • Export Citation
  • 10.

    Tarlov IM, , Klinger H, & Vitale S: Spinal cord compression studies. I. Experimental techniques to produce acute and gradual compression. Arch Neurol Psychiatry 70:813819, 1953 Tarlov IM, Klinger H, Vitale S: Spinal cord compression studies. I. Experimental techniques to produce acute and gradual compression. Arch Neurol Psychiatry 70:813–819, 1953

    • Search Google Scholar
    • Export Citation
  • 11.

    Tator CH, & Deecke L: Value of normothermic perfusion, hypothermic perfusion, and durotomy in the treatment of experimental acute spinal cord trauma. J Neurosurg 39:5264, 1973 Tator CH, Deecke L: Value of normothermic perfusion, hypothermic perfusion, and durotomy in the treatment of experimental acute spinal cord trauma. J Neurosurg 39:52–64, 1973

    • Search Google Scholar
    • Export Citation
  • 12.

    Wells JD, & Hansebout RR: Local hypothermia in experimental spinal cord trauma. Surg Neurol 10:200204, 1978 Wells JD, Hansebout RR: Local hypothermia in experimental spinal cord trauma. Surg Neurol 10:200–204, 1978

    • Search Google Scholar
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