Giant cell granuloma involving the pituitary gland

Case report

Restricted access

✓ The case is reported of a middle-aged man who had developed relatively acute, unilateral ophthalmoplegia. Radiological studies indicated a mass lesion involving the pituitary gland and right cavernous sinus. Pituitary tissue obtained by transsphenoidal hypophysectomy contained giant cell granuloma. In previous cases, the documentation of giant cell granuloma of the pituitary gland has been limited to autopsy tissue.

Article Information

Address reprint requests to: Thomas A. Duff, M.D., Division of Neurological Surgery, University of Wisconsin, Clinical Sciences Center, 600 Highland Avenue, Madison, Wisconsin 53792.

© AANS, except where prohibited by US copyright law.

Headings

Figures

  • View in gallery

    Upper Left: Plain film showing erosion of the sellar floor and an apparent soft-tissue mass lining the superior and posterior portions of the sphenoid sinus. Upper Right: Pneumoencephalogram revealing a small suprasellar extension (arrow) of the intrasellar mass. Lower: Orbital venogram showing poor filling of the right cavernous sinus (arrow).

  • View in gallery

    Anteroposterior (upper) and lateral (lower) views of the right (left pair) and left (right pair) carotid angiogram. There is lateral bowing and opening of the right carotid siphon.

  • View in gallery

    Photomicrograph of pituitary tissue showing infiltration by plasma cells and eosinophilic granulocytes; multinucleated giant cell at the center contains a refractile inclusion. H & E, × 250.

References

1.

Doniach IWright EA: Two cases of giant-cell granuloma of the pituitary gland. J Pathol Bacteriol 63:69791951Doniach I Wright EA: Two cases of giant-cell granuloma of the pituitary gland. J Pathol Bacteriol 63:69–79 1951

2.

Hunt WE: Tolosa-Hunt syndrome: one cause of painful ophthalmoplegia. J Neurosurg 44:5445491976Hunt WE: Tolosa-Hunt syndrome: one cause of painful ophthalmoplegia. J Neurosurg 44:544–549 1976

3.

Sheehan HLSummers VK: The syndrome of hypopituitarism. Q J Med 18:3193621949Sheehan HL Summers VK: The syndrome of hypopituitarism. Q J Med 18:319–362 1949

4.

Simmonds M: Über das Vorkommen von Riesenzellen in der Hypophyse. Virchows Arch Pathol Anat 223:2812901917Simmonds M: Über das Vorkommen von Riesenzellen in der Hypophyse. Virchows Arch Pathol Anat 223:281–290 1917

5.

Tolosa E: Periarteritic lesions of the carotid siphon with the clinical features of a carotid infraclinoidal aneurysm. J Neurol Neurosurg Psychiatry 17:3003021954Tolosa E: Periarteritic lesions of the carotid siphon with the clinical features of a carotid infraclinoidal aneurysm. J Neurol Neurosurg Psychiatry 17:300–302 1954

6.

Viale GL: Giant cell tumours of the sellar region. Acta Neurochir 38:2592681977Viale GL: Giant cell tumours of the sellar region. Acta Neurochir 38:259–268 1977

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 28 28 17
Full Text Views 186 186 16
PDF Downloads 52 52 10
EPUB Downloads 0 0 0

PubMed

Google Scholar