Effects of laminectomy on spinal cord blood flow

Douglas K. Anderson Ph.D.1, Gregory R. Nicolosi Ph.D.1, Eugene D. Means M.D.1, and L. Edward Hartley B.Sc.1
View More View Less
  • 1 Research Service, Tampa Veterans Administration Hospital, and Departments of Physiology, and Internal Medicine (Neurology Section), College of Medicine, University of South Florida, Tampa, Florida
Page Range:
232–238
Volume/Issue:
Volume 48: Issue 2
DOI link:
https://doi.org/10.3171/jns.1978.48.2.0232
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
Click here for subscription options

  • Purchase Now

    USD  $45.00

  • JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

    USD  $515.00

  • JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

    USD  $612.00
Print or Print + Online

✓ The effect of a one-segment (L-2) laminectomy on spinal cord blood flow (SCBF) was determined by the reference sample method using isotope-labeled microspheres. The SCBF was measured before laminectomy (control) and at 15 minutes postlaminectomy with the dura exposed (Series 1), 1 hour postlaminectomy with the laminectomy site closed (Series 2), 24 hours postlaminectomy with the laminectomy site closed (Series 3), and 24 hours postlaminectomy with the dura exposed (Series 4). With the laminectomy site open, SCBF was significantly depressed (22% to 45%) along the entire length of the spinal cord at 15 minutes postlaminectomy. At 1 hour postlaminectomy (with the laminectomy site closed), SCBF approached control values, although areas with significantly lowered flow were still observed in all portions of the spinal cord. By 24 hours postlaminectomy, SCBF had returned to prelaminectomy levels. However, if within 1 hour preceding the 24-hour SCBF measurement, the laminectomy site was reopened, SCBF tended to fall at and caudad to the laminectomy site. These data indicate that laminectomy can cause a significant decline in SCBF. At the present time, the mechanism(s) for this laminectomy-induced depression of SCBF are unknown, although a temperature-induced vasoconstriction is suspected.

Volume 48: Issue 2 (Feb 1978)

in Journal of Neurosurgery
Cover Journal of Neurosurgery

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $515.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $612.00
Click here for subscription options

  • JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

    USD  $515.00

  • JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

    USD  $612.00
Print or Print + Online
  • 1.

    Bingham WG, , Goldman H, & Friedman SJ, et al: Blood flow in normal and injured monkey spinal cord. J Neurosurg 43:162–171, 1975 Bingham WG, Goldman H, Friedman SJ, et al: Blood flow in normal and injured monkey spinal cord. J Neurosurg 43:162–171, 1975

    • Search Google Scholar
    • Export Citation
  • 2.

    Buckberg GD, , Luck JC, & Payne DB, et al: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604, 1971 Buckberg GD, Luck JC, Payne DB, et al: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604, 1971

    • Search Google Scholar
    • Export Citation
  • 3.

    Burke TJ: Dog nephron filtration rate (NFR): Errors in measurement. Fed Proc 35:541, 1976 (Abstract 1851) Burke TJ: Dog nephron filtration rate (NFR): Errors in measurement. Fed Proc 35:541, 1976 (Abstract 1851)

    • Search Google Scholar
    • Export Citation
  • 4.

    Ducker TB, & Lucas J: Recovery from spinal cord injury, in Seeman P, , Brown GM (eds): Frontiers in Neurology and Neuroscience Research. Toronto: University of Toronto Press, 1974, pp 142–154 Ducker TB, Lucas J: Recovery from spinal cord injury, in Seeman P, Brown GM (eds): Frontiers in Neurology and Neuroscience Research. Toronto: University of Toronto Press, 1974, pp 142–154

    • Search Google Scholar
    • Export Citation
  • 5.

    Flohr H-W, , Brock M, & Christ R, et al: Arterial pCO2 and blood flow in different parts of the central nervous system of the anesthesized cat, in Brock M, , Fieschi C, & Ingvar DH, et al: Cerebral Blood Flow: Clinical and Experimental Results. Berlin: Springer-Verlag, 1969, pp 86–88 Flohr H-W, Brock M, Christ R, et al: Arterial pCO2 and blood flow in different parts of the central nervous system of the anesthesized cat, in Brock M, Fieschi C, Ingvar DH, et al: Cerebral Blood Flow: Clinical and Experimental Results. Berlin: Springer-Verlag, 1969, pp 86–88

    • Search Google Scholar
    • Export Citation
  • 6.

    Griffiths IR: Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci 27:247–259, 1976 Griffiths IR: Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci 27:247–259, 1976

    • Search Google Scholar
    • Export Citation
  • 7.

    Griffiths IR: Spinal cord blood flow in dogs. 1. The ‘normal’ flow. 2. The effect of the blood gases. J Neurol Neurosurg Psychiatry 36:34–49, 1973 Griffiths IR: Spinal cord blood flow in dogs. 1. The ‘normal’ flow. 2. The effect of the blood gases. J Neurol Neurosurg Psychiatry 36:34–49, 1973

    • Search Google Scholar
    • Export Citation
  • 8.

    Griffiths IR, , Rowan JO, & Crawford RA: Spinal cord blood flow measured by a hydrogen clearance technique. J Neurol Sci 26:529–544, 1975 Griffiths IR, Rowan JO, Crawford RA: Spinal cord blood flow measured by a hydrogen clearance technique. J Neurol Sci 26:529–544, 1975

    • Search Google Scholar
    • Export Citation
  • 9.

    Hales JRS: Radioactive microsphere measurement of cardiac output and regional tissue blood flow in the sheep. Pfluegers Arch 344:119–132, 1973 Hales JRS: Radioactive microsphere measurement of cardiac output and regional tissue blood flow in the sheep. Pfluegers Arch 344:119–132, 1973

    • Search Google Scholar
    • Export Citation
  • 10.

    Kindt GW: Autoregulation of spinal cord blood flow. Eur Neurol 6:19–23, 1971–72 Kindt GW: Autoregulation of spinal cord blood flow. Eur Neurol 6:19–23, 1971–72

    • Search Google Scholar
    • Export Citation
  • 11.

    Kobrine AI: The neuronal theory of experimental traumatic spinal cord dysfunction. Surg Neurol 3:261–264, 1975 Kobrine AI: The neuronal theory of experimental traumatic spinal cord dysfunction. Surg Neurol 3:261–264, 1975

    • Search Google Scholar
    • Export Citation
  • 12.

    Kobrine AI, & Doyle TF: Role of histamine in posttraumatic spinal cord hyperemia and the luxury perfusion syndrome. J Neurosurg 44:16–20, 1976 Kobrine AI, Doyle TF: Role of histamine in posttraumatic spinal cord hyperemia and the luxury perfusion syndrome. J Neurosurg 44:16–20, 1976

    • Search Google Scholar
    • Export Citation
  • 13.

    Kobrine AI, , Doyle TF, & Martins AN: Local spinal cord blood flow in experimental traumatic myelopathy. J Neurosurg 42:144–149, 1975 Kobrine AI, Doyle TF, Martins AN: Local spinal cord blood flow in experimental traumatic myelopathy. J Neurosurg 42:144–149, 1975

    • Search Google Scholar
    • Export Citation
  • 14.

    Kobrine AI, , Doyle TF, & Newby N, et al: Preserved autoregulation in the rhesus spinal cord after high cervical cord section. J Neurosurg 44:425–428, 1976 Kobrine AI, Doyle TF, Newby N, et al: Preserved autoregulation in the rhesus spinal cord after high cervical cord section. J Neurosurg 44:425–428, 1976

    • Search Google Scholar
    • Export Citation
  • 15.

    Kobrine AI, , Doyle TF, & Rizzoli HV: Spinal cord blood flow as affected by changes in systemic arterial blood pressure. J Neurosurg 44:12–15, 1976 Kobrine AI, Doyle TF, Rizzoli HV: Spinal cord blood flow as affected by changes in systemic arterial blood pressure. J Neurosurg 44:12–15, 1976

    • Search Google Scholar
    • Export Citation
  • 16.

    Marcus ML, & Heistad DD: Regulation of spinal cord blood flow. Fed Proc 35:449, 1976 (Abstract 1340) Marcus ML, Heistad DD: Regulation of spinal cord blood flow. Fed Proc 35:449, 1976 (Abstract 1340)

    • Search Google Scholar
    • Export Citation
  • 17.

    McDonald FD, & Sparks HV: Decreased blood flow to the area prepared for renal micropuncture in the dog. Am Soc Nephrol, Fourth Annual Meeting. 1970, p 50 (Abstract) McDonald FD, Sparks HV: Decreased blood flow to the area prepared for renal micropuncture in the dog. Am Soc Nephrol, Fourth Annual Meeting. 1970, p 50 (Abstract)

    • Search Google Scholar
    • Export Citation
  • 18.

    Smith AL, , Pender JW, & Alexander SC: Effects of pCO2 on spinal cord blood flow. Am J Physiol 216:1158–1163, 1969 Smith AL, Pender JW, Alexander SC: Effects of pCO2 on spinal cord blood flow. Am J Physiol 216:1158–1163, 1969

    • Search Google Scholar
    • Export Citation
  • 19.

    Tschetter TH, , Klassen AC, & Resch JA, et al: Blood flow in the central and peripheral nervous system of dogs using a particle distribution method. Stroke 1:370–374, 1970 Tschetter TH, Klassen AC, Resch JA, et al: Blood flow in the central and peripheral nervous system of dogs using a particle distribution method. Stroke 1:370–374, 1970

    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 282 48 8
Full Text Views 154 1 0
PDF Downloads 93 0 0
EPUB Downloads 0 0 0