Pain reduction by electrical brain stimulation in man

Part 1: Acute administration in periaqueductal and periventricular sites

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  • 1 Division of Neurological Surgery, Louisiana State University, School of Medicine, New Orleans, Louisiana, and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California
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✓ Acute studies performed in five patients indicate that electrical stimulation of the brain could be a powerful tool for the reduction or control of intractable pain. While chronic or spontaneous pain could be relieved by stimulation of the periaqueductal gray matter, the accompanying side effects render it impossible to stimulate this site regularly. On the other hand, stimulation of medial thalamic sites, particularly medial to the nucleus parafascicularis, yielded good relief of chronic pain at parameters which did not cause many undesirable side effects. The same parameters also produced inhibition of acute pain in two of the five patients.

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Contributor Notes

Dr. Akil is currently supported by National Institutes of Health Fellowship NS 02337 and Alfred P. Sloan Research Fellowship in Neurophysiology BR-1609.

Address for Dr. Richardson: Suite 300, 2714 Canal Street, New Orleans, Louisiana 70119.

Address reprint requests to: Huda Akil, Ph.D., Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305.
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