Cerebral arterial spasm

Part 3: In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine

George S. Allen M.D.1, Lawrence H. A. Gold M.D.1, Shelley N. Chou M.D., Ph.D.1, and Lyle A. French M.D., Ph.D.1
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  • 1 Departments of Neurosurgery and Radiology, University of Minnesota Medical School, Minneapolis, Minnesota
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In vivo experiments in dogs demonstrated that physiological concentrations of serotonin, when injected intracisternally, caused cerebral arterial spasm that lasted for at least 3 hours. Comparable spasm was produced by the injection of blood containing approximately the same amount of serotonin. Phenoxybenzamine reversed both the spasm produced by pure serotonin and that produced by blood. A hypothesis of the etiology of cerebral arterial spasm is proposed based on the experimental results of the entire study.

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  • 1.

    Allen GS, , Henderson LM, & Chou SN, et al: Cerebral arterial spasm. Part 1: In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg 40:433441, 1974 Allen GS, Henderson LM, Chou SN, et al: Cerebral arterial spasm. Part 1: In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg 40:433–441, 1974

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  • 2.

    Allen GS, , Henderson LM, & Chou SN, et al: Cerebral arterial spasm. Part 2: In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery, and its blockage by methylsergide and phenoxybenzamine. J Neurosurg 40:442450, 1974 Allen GS, Henderson LM, Chou SN, et al: Cerebral arterial spasm. Part 2: In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery, and its blockage by methylsergide and phenoxybenzamine. J Neurosurg 40:442–450, 1974

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  • 3.

    Amplatz K: A see-through 36 inch roll film changer. Am J Roentgen 112:628630, 1971 Amplatz K: A see-through 36 inch roll film changer. Am J Roentgen 112:628–630, 1971

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    • Export Citation
  • 4.

    Blaschko H, & Levine WG: Metabolism of indolealkylamines, in Eichler O, & Farah A (eds): Handbuch der Experimentellen Pharmakologie. Handbook of Experimental Pharmacology, Vol XIX. Berlin, Springer-Verlag, 1966, pp 212244 Blaschko H, Levine WG: Metabolism of indolealkylamines, in Eichler O, Farah A (eds): Handbuch der Experimentellen Pharmakologie. Handbook of Experimental Pharmacology, Vol XIX. Berlin, Springer-Verlag, 1966, pp 212–244

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    • Export Citation
  • 5.

    Markwardt F: Studies on release of biogenic amines from blood platelets, in Kowalski E, & Niewiarowski S (eds): Biochemistry of Blood Platelets. New York, Academic Press, 1967, pp 105116 Markwardt F: Studies on release of biogenic amines from blood platelets, in Kowalski E, Niewiarowski S (eds): Biochemistry of Blood Platelets. New York, Academic Press, 1967, pp 105–116

    • Search Google Scholar
    • Export Citation
  • 6.

    Seldinger SI: Catheter replacement of the needle in percutaneous arteriography: new technique. Acta Radiol (Stockh) 39:368376, 1953 Seldinger SI: Catheter replacement of the needle in percutaneous arteriography: new technique. Acta Radiol (Stockh) 39:368–376, 1953

    • Search Google Scholar
    • Export Citation
  • 7.

    Weiner M, & Udenfriend S: Relationship of platelet serotinin to disturbances of clotting and hemostasis. Circulation 15:353357, 1957 Weiner M, Udenfriend S: Relationship of platelet serotinin to disturbances of clotting and hemostasis. Circulation 15:353–357, 1957

    • Search Google Scholar
    • Export Citation

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