Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma

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✓ With the use of a ventricular perfusion technique, a cerebrospinal fluid formation rate of 1.4 ml/min was determined in a 5-month-old child with a choroid plexus papilloma and hydrocephalus. This rate was slightly greater than four times the rate observed in normal children. The clinical course, as well as a measured absorption rate, indicated that the patient's capacity for absorption was normal.

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Address reprint requests to: Antonio V. Lorenzo, Ph.D., Children's Hospital Medical Center, 300 Longwood Avenue, Boston, Massachusetts 02115.

© AANS, except where prohibited by US copyright law.

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Figures

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    Brow-up ventriculogram showing moderate dilatation of the lateral and third ventricles. The left ventricle is larger than the right. Gas injected into the subarachnoid space at the convexity shows enlargement of this space.

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    Vertebral arteriogram, venous phase, showing a vascular blush in the region of the left trigone.

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    Photomicrographs of the surgical specimen showing a typical choroid plexus papilloma. Left: PTAH, × 115. Right: H & E, × 230.

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    I125 albumin activity in the lumbar effluent (C0) and the inflow (C1) per unit volume and time plotted as a function of time; CPM = counts per minute.

References

  • 1.

    Cutler RWPMurray JEMoody RA: Overproduction of cerebrospinal fluid in communicating hydrocephalus. A case report. Neurology 23:151973Cutler RWP Murray JE Moody RA: Overproduction of cerebrospinal fluid in communicating hydrocephalus. A case report. Neurology 23:1–5 1973

    • Search Google Scholar
    • Export Citation
  • 2.

    Cutler RWPPage LGalicich Jet al: Formation and absorption of cerebrospinal fluid in man. Brain 91:7077201968Cutler RWP Page L Galicich J et al: Formation and absorption of cerebrospinal fluid in man. Brain 91:707–720 1968

    • Search Google Scholar
    • Export Citation
  • 3.

    Fairburn B: Choroid plexus papilloma and its relation to hydrocephalus. J Neurosurg 17:1661711960Fairburn B: Choroid plexus papilloma and its relation to hydrocephalus. J Neurosurg 17:166–171 1960

    • Search Google Scholar
    • Export Citation
  • 4.

    Heisey SRHeld DPappenheimer JR: Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol 203:7757811962Heisey SR Held D Pappenheimer JR: Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol 203:775–781 1962

    • Search Google Scholar
    • Export Citation
  • 5.

    Herren RY: Papilloma of the choroid plexus. Arch Surg 42:7587741941Herren RY: Papilloma of the choroid plexus. Arch Surg 42:758–774 1941

    • Search Google Scholar
    • Export Citation
  • 6.

    Johnson RT: Clinicopathological aspects of the cerebrospinal fluid circulation in Wolstenholme GEWO'Connor CM (eds): Ciba Foundation Symposium on the Cerebrospinal Fluid: Production Circulation and Absorption. BostonLittle, Brown1957 pp 265281Johnson RT: Clinicopathological aspects of the cerebrospinal fluid circulation in Wolstenholme GEW O'Connor CM (eds): Ciba Foundation Symposium on the Cerebrospinal Fluid: Production Circulation and Absorption. Boston Little Brown 1957 pp 265–281

    • Search Google Scholar
    • Export Citation
  • 7.

    Kahn EALuros JT: Hydrocephalus from overproduction of cerebrospinal fluid (and experiences with other papillomas of the choroid plexus). J Neurosurg 9:58671952Kahn EA Luros JT: Hydrocephalus from overproduction of cerebrospinal fluid (and experiences with other papillomas of the choroid plexus). J Neurosurg 9:58–67 1952

    • Search Google Scholar
    • Export Citation
  • 8.

    Lorenzo AVPage LKWatters GV: Relationship between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain 93:6796921970Lorenzo AV Page LK Watters GV: Relationship between cerebrospinal fluid formation absorption and pressure in human hydrocephalus. Brain 93:679–692 1970

    • Search Google Scholar
    • Export Citation
  • 9.

    Matson DDCrofton FDL: Papilloma of the choroid plexus in childhood. J Neurosurg 17:100210271960Matson DD Crofton FDL: Papilloma of the choroid plexus in childhood. J Neurosurg 17:1002–1027 1960

    • Search Google Scholar
    • Export Citation
  • 10.

    Pappenheimer JRHeisey SRJordan EFet al: Perfusion of the cerebral ventricular system in unanesthetized goats. Am J Physiol 203:7637741962Pappenheimer JR Heisey SR Jordan EF et al: Perfusion of the cerebral ventricular system in unanesthetized goats. Am J Physiol 203:763–774 1962

    • Search Google Scholar
    • Export Citation
  • 11.

    Ray BSPeck FC Jr: Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant. J Neurosurg 13:4054101956Ray BS Peck FC Jr: Papilloma of the choroid plexus of the lateral ventricles causing hydrocephalus in an infant. J Neurosurg 13:405–410 1956

    • Search Google Scholar
    • Export Citation
  • 12.

    Ringertz NReymond A: Ependymomas and choroid plexus papillomas. J Neuropath Exp Neurol 8:3553801949Ringertz N Reymond A: Ependymomas and choroid plexus papillomas. J Neuropath Exp Neurol 8:355–380 1949

    • Search Google Scholar
    • Export Citation
  • 13.

    Rubin RCHenderson ESOmmaya AKet al: The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg 25:4304361966Rubin RC Henderson ES Ommaya AK et al: The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg 25:430–436 1966

    • Search Google Scholar
    • Export Citation
  • 14.

    Russell DS: Observations on the pathology of hydrocephalus. Spec Rep Ser Med Res Counc No 2651966Russell DS: Observations on the pathology of hydrocephalus. Spec Rep Ser Med Res Counc No 265 1966

    • Search Google Scholar
    • Export Citation
  • 15.

    Vigouroux A: Écoulement de liquide céphalorachidien. Hydrocéphalic papillome des plexus choroides du IVe ventricule. Rev Neurol 16:2812851908Vigouroux A: Écoulement de liquide céphalorachidien. Hydrocéphalic papillome des plexus choroides du IVe ventricule. Rev Neurol 16:281–285 1908

    • Search Google Scholar
    • Export Citation

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