Experimental Pantopaque ventriculography

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  • 1 Laboratory of Pathology, Division of Biologics Standards, and Branch of Surgical Neurology, National Institute of Neurological Diseases and Stroke, and Laboratory of Psychology, National Institute of Mental Health, Department of Health, Education, and Welfare, Bethesda, Maryland
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✓ The injection of Pantopaque into the ventricles of normal and hydrocephalic dogs produced a variety of acute and chronic pathological changes. Multiple granulomatous lesions developed in the ventricular wall and the surrounding brain parenchyma, choroid plexus, cranial nerves, and arachnoid membrane. Adhesions formed in several areas of the ventricles, and Pantopaque became encysted in the third ventricle and tips of the temporal horns. In general there were more serious changes in the animals that had a greater degree of hydrocephalus. Relatively mild lesions were noted in normal animals.

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Contributor Notes

Address reprint requests to: Dr. Ronald G. Clark, Department of Biological Structure, University of Miami School of Medicine, 1600 N.W. 10th Avenue, Miami, Florida 33152.
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