Experimental Hydrocephalus Produced by the Subarachnoid Infusion of Silicone Oil

Restricted access

If the inline PDF is not rendering correctly, you can download the PDF file here.

Article Information

U.S. Public Health Service International Post-doctoral Fellow No. 3F05-TW-01263-0151. Present address: Department of Pathology, Guy's Hospital, London S.E.1, England.

© AANS, except where prohibited by US copyright law.

Headings

Figures

  • View in gallery

    Coronal section of hydrocephalic puppy brain 4 weeks after subarachnoid infusion of silicone oil. There is marked dilatation of the posterior parts of the lateral ventricles and of the temporal horns with thinning of the white matter.

  • View in gallery

    Adult rabbit brain showing dilatation of the anterior portions of the lateral ventricles and the temporal horns 16 weeks after infusion of silicone oil through the spinal subarachnoid space.

  • View in gallery

    Left: Normal rabbit brain with an intact epiphyseal recess viewed from above. Right: Rabbit brain 8 weeks after subarachnoid infusion of silicone oil showing separations of the occipital lobes following dilatation and subsequent rupture of the pineal recess.

  • View in gallery

    Left: Normal rabbit brain sectioned through the anterior pontine region. Epiphyseal recess is intact. Right: Rabbit brain with moderate hydrocephalus. The occipital lobes are displaced and the epiphyseal recess has ruptured.

  • View in gallery

    Left: Rabbit brain viewed from above showing normal cerebellar configuration with a gap between the cerebellum and the occipital lobes. Right: Adult rabbit brain showing compression of the cerebellum following repeated infusions of oil through a spinal catheter. The superior vermis is herniated through the incisure of the tentorium. Rupture of the pineal recess has not occurred, and coronal section of the brain shows marked hydrocephalus (Fig. 2).

References

  • 1.

    Ariëns-KappersC. U.HuberG. C. and CrosbyE. C. The comparative anatomy of the nervous system of vertebrates including man. New York: Hafner Publ. Co.19603 vols. (See vol. 3 p. 1406.)Ariëns-Kappers C. U. Huber G. C. and Crosby E. C. The comparative anatomy of the nervous system of vertebrates including man. New York: Hafner Publ. Co. 1960 3 vols. (See vol. 3 p. 1406.)

    • Search Google Scholar
    • Export Citation
  • 2.

    DandyW. E. Experimental hydrocephalus. Ann. Surg.191970:129142.Dandy W. E. Experimental hydrocephalus. Ann. Surg. 1919 70:129–142.

    • Search Google Scholar
    • Export Citation
  • 3.

    DandyW. E. and BlackfanK. D. An experimental and clinical study of internal hydrocephalus. J. Am. med. Ass.191361:22162217.Dandy W. E. and Blackfan K. D. An experimental and clinical study of internal hydrocephalus. J. Am. med. Ass. 1913 61:2216–2217.

    • Search Google Scholar
    • Export Citation
  • 4.

    DeS. N. A study of the changes in the brain in experimental internal hydrocephalus. J. Path. Bact.195062:197207.De S. N. A study of the changes in the brain in experimental internal hydrocephalus. J. Path. Bact. 1950 62:197–207.

    • Search Google Scholar
    • Export Citation
  • 5.

    GarroF. and PentschewA. Neonatal hydrocephalus in the offspring of rats fed during pregnancy non-toxic amounts of tellurium. Arch. Psychiat. NervKrankh.1964206:272280.Garro F. and Pentschew A. Neonatal hydrocephalus in the offspring of rats fed during pregnancy non-toxic amounts of tellurium. Arch. Psychiat. NervKrankh. 1964 206:272–280.

    • Search Google Scholar
    • Export Citation
  • 6.

    JohnsonR. T.JohnsonK. P. and EdmondsC. J. Virus-induced hydrocephalus: development of aqueductal stenosis in hamsters after mumps injection. Science N.Y.1967157:10661067.Johnson R. T. Johnson K. P. and Edmonds C. J. Virus-induced hydrocephalus: development of aqueductal stenosis in hamsters after mumps injection. Science N.Y. 1967 157:1066–1067.

    • Search Google Scholar
    • Export Citation
  • 7.

    PudenzR. H.RussellF. E. and AgnewW. F. Experimental hydrocephalus: a historical summary. Bull. Los Ang. neurol. Soc.196025:118129.Pudenz R. H. Russell F. E. and Agnew W. F. Experimental hydrocephalus: a historical summary. Bull. Los Ang. neurol. Soc. 1960 25:118–129.

    • Search Google Scholar
    • Export Citation
  • 8.

    SchurrP. H.McLaurinR. L. and IngrahamF. D. Experimental studies on the circulation of the cerebrospinal fluid: and methods of producing communicating hydrocephalus in dogs. J. Neurosurg.195310:515525.Schurr P. H. McLaurin R. L. and Ingraham F. D. Experimental studies on the circulation of the cerebrospinal fluid: and methods of producing communicating hydrocephalus in dogs. J. Neurosurg. 1953 10:515–525.

    • Search Google Scholar
    • Export Citation
  • 9.

    StempakJ. G. Etiology of trypan blue induced antenatal hydrocephalus in the albino rat. Anat. Rec.1964148:561571.Stempak J. G. Etiology of trypan blue induced antenatal hydrocephalus in the albino rat. Anat. Rec. 1964 148:561–571.

    • Search Google Scholar
    • Export Citation
  • 10.

    WellerR. O. and WisniewskiH. Histological and ultrastructural changes with experimental hydrocephalus in adult rabbits. Brain1969. (In press.)Weller R. O. and Wisniewski H. Histological and ultrastructural changes with experimental hydrocephalus in adult rabbits. Brain 1969. (In press.)

    • Search Google Scholar
    • Export Citation
  • 11.

    WisniewskiH. Research on experimental filling of the ventricular system of dogs. Acta Neuropath.19611:238244.Wisniewski H. Research on experimental filling of the ventricular system of dogs. Acta Neuropath. 1961 1:238–244.

    • Search Google Scholar
    • Export Citation

TrendMD

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 42 42 4
Full Text Views 162 162 0
PDF Downloads 58 58 0
EPUB Downloads 0 0 0

PubMed

Google Scholar