Hemorrhage risk of cerebral dural arteriovenous fistulas following Gamma Knife radiosurgery in a multicenter international consortium

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  • 1 Department of Neurological Surgery, University of Miami, Florida;
  • | 2 Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;
  • | 3 Department of Neurological Surgery, University of Pittsburgh;
  • | 4 Department of Neurological Surgery, University of Pennsylvania, Philadelphia, Pennsylvania;
  • | 5 Department of Neurological Surgery, University of Sherbrooke, Quebec, Canada,
  • | 6 Department of Neurological Surgery, University of Manitoba, Winnipeg, Manitoba, Canada;
  • | 7 Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan;
  • | 8 Departments of Neurological Surgery and
  • | 9 Radiation Oncology, West Virginia University, Morgantown, West Virginia;
  • | 10 Department of Neurological Surgery, Na Homolce Hospital, Prague, Czech Republic;
  • | 11 Department of Neurological Surgery, University of Puerto Rico, San Juan, Puerto Rico; and
  • | 12 Department of Neurological Surgery, Yale University School of Medicine, New Haven, Connecticut
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OBJECTIVE

The authors performed a study to evaluate the hemorrhagic rates of cerebral dural arteriovenous fistulas (dAVFs) and the risk factors of hemorrhage following Gamma Knife radiosurgery (GKRS).

METHODS

Data from a cohort of patients undergoing GKRS for cerebral dAVFs were compiled from the International Radiosurgery Research Foundation. The annual posttreatment hemorrhage rate was calculated as the number of hemorrhages divided by the patient-years at risk. Risk factors for dAVF hemorrhage prior to GKRS and during the latency period after radiosurgery were evaluated in a multivariate analysis.

RESULTS

A total of 147 patients with dAVFs were treated with GKRS. Thirty-six patients (24.5%) presented with hemorrhage. dAVFs that had any cortical venous drainage (CVD) (OR = 3.8, p = 0.003) or convexity or torcula location (OR = 3.3, p = 0.017) were more likely to present with hemorrhage in multivariate analysis. Half of the patients had prior treatment (49.7%). Post-GRKS hemorrhage occurred in 4 patients, with an overall annual risk of 0.84% during the latency period. The annual risks of post-GKRS hemorrhage for Borden type 2–3 dAVFs and Borden type 2–3 hemorrhagic dAVFs were 1.45% and 0.93%, respectively. No hemorrhage occurred after radiological confirmation of obliteration. Independent predictors of hemorrhage following GKRS included nonhemorrhagic neural deficit presentation (HR = 21.6, p = 0.027) and increasing number of past endovascular treatments (HR = 1.81, p = 0.036).

CONCLUSIONS

Patients have similar rates of hemorrhage before and after radiosurgery until obliteration is achieved. dAVFs that have any CVD or are located in the convexity or torcula were more likely to present with hemorrhage. Patients presenting with nonhemorrhagic neural deficits and a history of endovascular treatments had higher risks of post-GKRS hemorrhage.

ABBREVIATIONS

AVM = arteriovenous malformation; CVD = cortical venous drainage; dAVF = dural arteriovenous fistula; GKRS = Gamma Knife radiosurgery; NHND = nonhemorrhagic neural deficit.

Illustration from Duan et al. (pp 1174–1181).

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