An artists depiction of a proposed method to deliver endovascular care via a teleoperated robot in space. A patient located on a satellite orbiting the Earth is undergoing a telesurgical endovascular intervention via the CorPath device. Real-time angiography images are beamed back to Earth, where an operator (in this case, a humanoid robot) is controlling the robot over a long distance. Copyright Gavin W. Britz. Published with permission. See the article by Panesar et al. (pp 971–978).
Authors:Robert E. Gross, Edward K. Sung, Patrick Mulligan, Nealen G. Laxpati, Darlene A. Mayo and John D. Rolston
The authors evaluated the accuracy of a technique for inserting intracranial electrodes for epilepsy monitoring that does not rely on a traditional stereotactic frame (“frameless”). It is important because they found that the accuracy was only 5.2 mm. This may be sufficient to identify the onset region of epileptic seizures in patients with temporal lobe epilepsy, who comprised most of the patients in this study, but not necessarily for other types of epilepsy that demand greater accuracy.
Authors:Philip L. Perez, Sarah S. Wang, Susan Heath, Jennifer Henderson-Sabes, Danielle Mizuiri, Leighton B. Hinkley, Srikantan S. Nagarajan, Paul S. Larson and Steven W. Cheung
Authors of this study investigated whether there is a difference between two parts of the caudate nucleus in the brain by determining tinnitus (ringing in the ears) responses to electrical stimulation and evaluating their connections to the auditory forebrain. The body of the caudate nucleus is more likely to change tinnitus loudness and is more strongly connected to the hearing system. This information will help to target tinnitus treatment delivery more precisely.
Authors:Feng Yan, Gary Rajah, Yuchuan Ding, Yang Hua, Hongqi Zhang, Liqun Jiao, Guilin Li, Ming Ren, Ran Meng, Feng Lin and Xunming Ji
This study explored a new method (intravascular ultrasound) to guide the diagnosis and treatment of a special cerebral vascular disease, i.e., cerebral venous sinus stenosis–induced idiopathic intracranial hypertension. This method may help decrease the risk of adjacent-site stenosis following venous stenting.
The authors investigated the effectiveness of a detailed standardized surgical protocol to prevent infection in patients undergoing cerebrospinal fluid (CSF) shunt surgery. The use of this protocol could reduce infection after CSF shunt surgery in patients of all ages.
Authors:Christian Lopez Ramos, Robert C. Rennert, Michael G. Brandel, Peter Abraham, Brian R. Hirshman, Jeffrey A. Steinberg, David R. Santiago-Dieppa, Arvin R. Wali, Kevin Porras, Yazeed Almosa, Jeffrey S. Pannell and Alexander A. Khalessi
The authors examined the impact of safety-net hospitals on the treatment of patients with emergent ruptured cerebral aneurysms. Despite their financial burden, safety-net hospitals may have the capacity to provide equitable care for complex and emergent neurosurgical conditions that require highly coordinated and resource-intensive postoperative services. The impact of payment reform policies should be closely monitored to ensure that these policies support safety-net hospitals in improving quality and safety of healthcare without threatening their financial viability.
Authors:Jan-Karl Burkhardt, Omar Tanweer, Miguel Litao, Pankaj Sharma, Eytan Raz, Maksim Shapiro, Peter Kim Nelson and Howard A. Riina
The authors compared infection rates in patients with and without prophylactic antibiotics before endovascular neurointerventions. The results of this study might have an impact on antibiotic use in this setting and help to prevent the development of antibiotic resistance and decrease drug-related side effects.
Authors:Vincenzo Levi, Nicola Ernesto Di Laurenzio, Andrea Franzini, Irene Tramacere, Alessandra Erbetta, Luisa Chiapparini, Domenico D’Amico, Angelo Franzini and Giuseppe Messina
Assess the long-term efficacy of blind lumbar EPB and MRI pre-operative predictors of good outcome. To date, no clear evidences exist regarding the best administration method of blood patch (blind Vs target procedures).
Authors:Sasha Vaziri, Joseph M. Abbatematteo, Max S. Fleisher, Alexander B. Dru, Dennis T. Lockney, Paul S. Kubilis and Daniel J. Hoh
This study evaluated how risk prediction scores (based on patient risk factors before surgery) correlated to increased hospital cost—interestingly, these risk prediction scores do not correlate to actual occurrence of a complication but are able to distinguish which patients cost the hospital more. This is important because predicting patient cost may be advantageous in the current value-based healthcare environment.
Authors:Pepijn O. Sun, Ruud W. Selles, Miguel C. Jansen, Harm P. Slijper, Dietmar J. O. Ulrich and Erik T. Walbeehm
The authors studied the outcome and predictors of the outcome of revision surgery for recurrent and persistent carpal tunnel syndrome. The authors believe that their findings are important because they can be used to inform both patient and surgeon to manage expectations on improvement of symptoms.
In the rat model, the proximal nerve stump capping with a nerve conduit which length is more than four times the original nerve diameter could relief the pain, and it was considered to be a useful treatment of the painful stump neuroma.
Authors:Riho Nakajima, Masashi Kinoshita, Tetsutaro Yahata and Mitsutoshi Nakada
The authors analyzed data from 20 cases in which patients had undergone resection of a frontal lobe glioma involving the supplementary motor area and identified 2 factors that could predict time to recovery from paralysis due to SMA syndrome: severity of paralysis 1 week after surgery and disconnection probability of the cingulum. Being able to predict how long it will take for this paralysis to resolve can be helpful to medical professionals as well as patients and their families.
Authors:Tae Hoon Roh, Seok-Gu Kang, Ju Hyung Moon, Kyoung Su Sung, Hun Ho Park, Se Hoon Kim, Eui Hyun Kim, Chang-Ki Hong, Chang-Ok Suh and Jong Hee Chang
The authors investigated whether additional lobectomy after the complete removal of glioblastoma affected survival. They suggest a surgical strategy that can give the best survival outcome to patients with glioblastoma.
Authors:Cheng-Bei Li, Lai-Rong Song, Da Li, Jian-Cong Weng, Li-Wei Zhang, Jun-Ting Zhang and Zhen Wu
The study aims to identify the prognostic factors for primary intracranial malignant melanomas (PIMMs) and to propose an optimal and individualized treatment paradigm for patients with PIMMs. Identifying prognostic factors and optimal treatment options for these patients is important because there is currently no consensus regarding treatment of PIMMs.
Authors:Gennadiy A. Katsevman, Ryan C. Turner, Ogaga Urhie, Joseph L. Voelker and Sanjay Bhatia
The authors performed a retrospective study to assess sodium fluorescein as an adjunct in glioblastoma resection. The use of fluorescein increased rates of gross- or near-total resections (statistically significant) and improved the median survival of patients in whom it was used to guide resection compared with patients in whom it was not used (statistically insignificant).
Authors:Asif Raza Shafiq, A. Gabriella Wernicke, Charles Alex Riley, Peter F. Morgenstern, Lucy Nedialkova, Susan C. Pannullo, Bhupesh Parashar, Rajiv Magge and Theodore H. Schwartz
The authors have demonstrated and described a reproducible technique for the permanent implantation of low-dose brachytherapy seeds through an endoscopic endonasal approach, which has not previously been described in such detail.
Authors:Lonnie Schneider, Ethan Reichert, Jenna Faulkner, Brielle Reichert, Joshua Sonnen and Gregory W. J. Hawryluk
This preclinical study shows that peripheral exposure to spinal cord as occurs in spinal cord injury can induce autoimmunity, which causes delayed damage to both the brain and spinal cord. This could also be the etiology of chronic traumatic encephalopathy.
Authors:A. Scott Emmert, Shawn M. Vuong, Crystal Shula, Diana Lindquist, Weihong Yuan, Yueh-Chiang Hu, Francesco T. Mangano and June Goto
The authors created the first rat model of X-linked hydrocephalus through the CRISPR/Cas9 genome editing system. They studied periventricular white matter tracts of the hydrocephalus rats in advanced MRI and histology. This study uncovered the nature of abnormal MRI properties at the cellular level, which is not technically feasible to test in human clinical studies.
Authors:Weijun Wang, Steve Swenson, Hee-Yeon Cho, Florence M. Hofman, Axel H. Schönthal and Thomas C. Chen
This preclinical animal study demonstrates that intranasal delivery with a NEO100-based formulation enables non-invasive, therapeutically effective brain delivery of a pharmaceutical agent that otherwise does not efficiently cross the blood-brain barrier. This type of NEO100-mediated delivery of therapeutic agents into the brain could potentially be very beneficial for patients who suffer from brain malignancies or CNS disorders.