Letter to the Editor. Establishing the role of prophylactic antiepileptic drugs in glioma and meningioma surgery

Michael D. Jenkinson FRCS, PhD 1 , 2 , Arousa Ali MBChB, MRes 1 , 2 , Abdurrahman I. Islim MPhil 1 , 2 , Adel Helmy FRCS, PhD 3 and Robin Grant FRCP, MD 4
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  • 1 The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom;
  • 2 Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;
  • 3 University of Cambridge, Cambridge, United Kingdom; and
  • 4 Western General Hospital, Edinburgh, United Kingdom
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Contributor Notes

Correspondence Michael D. Jenkinson: michael.jenkinson@liv.ac.uk.

INCLUDE WHEN CITING Published online June 28, 2019; DOI: 10.3171/2019.1.JNS19134.

Disclosures The authors report no conflict of interest.

  • 1

    Dewan MC, Thompson RC, Kalkanis SN, Barker FG II, Hadjipanayis CG: Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS/CNS Section on Tumors survey. J Neurosurg 126:17721778, 2017

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  • 2

    Islim AI, Ali A, Bagchi A, Ahmad MU, Mills SJ, Chavredakis E, : Postoperative seizures in meningioma patients: improving patient selection for antiepileptic drug therapy. J Neurooncol 140:123134, 2018

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  • 3

    Joiner EF, Youngerman BE, Hudson TS, Yang J, Welch MR, McKhann GM II, : Effectiveness of perioperative antiepileptic drug prophylaxis for early and late seizures following oncologic neurosurgery: a meta-analysis. J Neurosurg 130:12741282, 2019

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  • 4

    Jyonouchi HG, Geng L: Intractable epilepsy (IE) and responses to anakinra, a human recombinant IL-1 receptor antagonist (IL-1ra): case reports. J Clin Cell Immunol 7:456, 2016

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  • 1

    Franceschetti S, Binelli S, Casazza M, Lodrini S, Panzica F, Pluchino F, : Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochir (Wien) 103:4751, 1990

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  • 2

    Glantz MJ, Cole BF, Forsyth PA, Recht LD, Wen PY, Chamberlain MC, : Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 54:18861893, 2000

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  • 3

    Grant R WC, Jenkinson M, Vale L, Marson T, Hill R, McEleny T: Seizure Prophylaxis in Glioma (SPRING): A phase III randomised trial comparing prophylactic Levetiracetam versus no prophylactic antiepileptic drug in newly diagnosed presumed supratentorial glioma. National Cancer Research Institute Cancer Conference (Abstract) (http://abstracts.ncri.org.uk/abstract/seizure-prophylaxis-in-glioma-spring-a-phase-iii-randomised-trial-comparing-prophylactic-levetiracetam-versus-no-prophylactic-anti-epileptic-drug-in-newly-diagnosed-presumed-supratentori/) [Accessed May 22, 2019]

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  • 4

    Wu AS, Trinh VT, Suki D, Graham S, Forman A, Weinberg JS, : A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg 118:873883, 2013

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