Increased glycemic variability associated with a poor 30-day functional outcome in acute intracerebral hemorrhage

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The authors analyzed the association between the standard deviation or the coefficient of variation in the glucose value, strong independent indexes for determining glycemic variability, and the prognosis of intracerebral hemorrhage. They found that glycemic variability may be associated with a poor outcome in intracerebral hemorrhage.

ABBREVIATIONS AUC = area under the receiver operating characteristic curve; CV = coefficient of variation; DBP = diastolic blood pressure; DM = diabetes mellitus; FBG = fasting blood glucose; GCS = Glasgow Coma Scale; GluCV = coefficient of variation of glucose; GluSD = standard deviation of glucose; GV = glycemic variability; HbAlc = glycosylated hemoglobin; HDL-C = high-density lipoprotein cholesterol; ICH = intracerebral hemorrhage; IVH = intraventricular hematoma; LDL-C = low-density lipoprotein cholesterol; MI = myocardial infarction; mRS = modified Rankin Scale; NG = normal glucose; SBP = systolic blood pressure; SD = standard deviation; SHG = stress hyperglycemia; TC = total cholesterol; TG = triglyceride; WBC = white blood cell.

Article Information

Correspondence Qing-Ying Zhang, Department of Preventive Medicine, Shantou University Medical College, 22 Xinling Rd., Shantou, Guangdong 515041, China. email:

INCLUDE WHEN CITING Published online November 3, 2017; DOI: 10.3171/2017.4.JNS162238.

Disclosures The authors report no conflict of interest concerning the materials and methods used in this study or the finding specified in this paper.

© AANS, except where prohibited by US copyright law.



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    Dynamic changes in 7-day FBG level in 3 glucose groups of hospitalized patients with ICH. Figure is available in color online only.

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    Poor prognosis and mortality rate at 30 days in 3 glucose groups of hospitalized ICH patients.

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    Receiver operating characteristic curves for the original, GluSD (SD), and GluCV (CV) models for predicting 30-day poor outcome in ICH. Figure is available in color online only.



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