Rupture prediction of intracranial aneurysms: a nationwide matched case-control study of hemodynamics at the time of diagnosis

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The authors used computer simulation to investigate the hemodynamics in 36 unruptured aneurysms on the first day the lesions were discovered; 12 of them later ruptured. Knowledge about any differences in hemodynamics at this early stage improves predictions about which patients will get a subarachnoid hemorrhage—a dangerous bleeding in the brain—and helps decide which patients should be treated in advance to avoid the bleeding.

ABBREVIATIONS ACoA = anterior communicating artery; CFD = computational fluid dynamics; IA = intracranial aneurysm; ICA = internal carotid artery; ICI = inflow concentration index; IQR = interquartile range; LSA = low shear area; MCA = middle cerebral artery; OSI = oscillatory shear index; PCoA = posterior communicating artery; PHASES = population, hypertension, age, size of aneurysm, earlier SAH from another aneurysm, site of aneurysm; PLc = pressure loss coefficient; SAH = subarachnoid hemorrhage; VDR = viscous dissipation ratio; WSS = wall shear stress.

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Article Information

Correspondence Torbjørn Øygard Skodvin, Varden 197, Tromsø 9018, Norway. email: torbjorn.skodvin@uit.no.

INCLUDE WHEN CITING Published online November 3, 2017; DOI: 10.3171/2017.5.JNS17195.

Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

© AANS, except where prohibited by US copyright law.

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    Boxplot showing graphic representation of the distribution of selected hemodynamic parameters in cases and controls. LnWSS = averaged logarithmic WSS; MinLnWSS = minimum logarithmic WSS.

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    Visualization of WSS and LSA for all case and control aneurysms, grouped by location. The WSS is represented by a color scale ranging from blue for WSS < 1.0 Pa, to red for WSS > 10 Pa. Areas of low shear are colored gray, and represent areas of the dome where the average WSS is below 10% of the average WSS in the parent artery. ACOM = ACoA; PCOM = PCoA.

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