Intracranial bifurcation aneurysms are complex lesions for which current therapy, including simple coiling, balloon- or stent-assisted coiling, coil retention, or intrasaccular devices, is inadequate. Thromboembolic complications due to a large burden of intraluminal metal, impedance of access to side branches, and a high recurrence rate, due largely to the unmitigated high-pressure flow into the aneurysm (water hammer effect), are among the limitations imposed by current therapy. The authors describe herein a novel device, eCLIPs, and its use in a preclinical laboratory study that suggests the device's design and functional features may overcome many of these limitations.
A preclinical model of wide-necked bifurcation aneurysms in rabbits was used to assess functional features and efficacy of aneurysm occlusion by the eCLIPs device.
The eCLIPs device, in bridging the aneurysm neck, allows coil retention, disrupts flow away from the aneurysm, leaves the main vessel and side branches unencumbered by intraluminal metal, and serves as a platform for endothelial growth across the neck, excluding the aneurysm from the circulation.
The eCLIPs device permits physiological remodeling of the bifurcation.
Correspondence Thomas R. Marotta, Diagnostic and Therapeutic Neuroradiology, St. Michael's Hospital, 30 Bond St., Toronto, ON M5B 1W8, Canada. email: email@example.com.
INCLUDE WHEN CITING Published online March 17, 2017; DOI: 10.3171/2016.10.JNS162024.
Drs. Marotta, Riina, and Ricci and Mr. McDougall contributed equally to this work.
Disclosures The preclinical trial was supported entirely by Evasc Medical Systems Corp., Vancouver, BC, Canada. The authors also report the following. Dr. Marotta: financial stakeholder in Evasc Neurovascular, and medical consultant and proctor for eCLIPs, part of Evasc. Dr. Riina: financial stakeholder in Evasc Neurovascular. Mr. McDougall: employee of Evasc Medical Systems Corp. Dr. Ricci: financial stakeholder in Evasc Neurovascular.
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