Methodology and reporting of meta-analyses in the neurosurgical literature

A review

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  • 1 Semmes-Murphey Neurologic & Spine Institute;
  • 2 Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee;
  • 3 School of Public Health and Health Services, The George Washington University, Washington, DC; and
  • 4 Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon
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Object

Neurosurgeons are inundated with vast amounts of new clinical research on a daily basis, making it difficult and time-consuming to keep up with the latest literature. Meta-analysis is an extension of a systematic review that employs statistical techniques to pool the data from the literature in order to calculate a cumulative effect size. This is done to answer a clearly defined a priori question. Despite their increasing popularity in the neurosurgery literature, meta-analyses have not been scrutinized in terms of reporting and methodology.

Methods

The authors performed a literature search using PubMed/MEDLINE to locate all meta-analyses that have been published in the JNS Publishing Group journals (Journal of Neurosurgery, Journal of Neurosurgery: Pediatrics, Journal of Neurosurgery: Spine, and Neurosurgical Focus) or Neurosurgery. Accepted checklists for reporting (PRISMA) and methodology (AMSTAR) were applied to each meta-analysis, and the number of items within each checklist that were satisfactorily fulfilled was recorded. The authors sought to answer 4 specific questions: Are meta-analyses improving 1) with time; 2) when the study met their definition of a meta-analysis; 3) when clinicians collaborated with a potential expert in meta-analysis; and 4) when the meta-analysis was the only focus of the paper?

Results

Seventy-two meta-analyses were published in the JNS Publishing Group journals and Neurosurgery between 1990 and 2012. The number of published meta-analyses has increased dramatically in the last several years. The most common topics were vascular, and most were based on observational studies. Only 11 papers were prepared using an established checklist. The average AMSTAR and PRISMA scores (proportion of items satisfactorily fulfilled divided by the total number of eligible items in the respective instrument) were 31% and 55%, respectively. Major deficiencies were identified, including the lack of a comprehensive search strategy, study selection and data extraction, assessment of heterogeneity, publication bias, and study quality. Almost one-third of the papers did not meet our basic definition of a meta-analysis. The quality of reporting and methodology was better 1) when the study met our definition of a meta-analysis; 2) when one or more of the authors had experience or expertise in conducting a meta-analysis; 3) when the meta-analysis was not conducted alongside an evaluation of the authors' own data; and 4) in more recent studies.

Conclusions

Reporting and methodology of meta-analyses in the neurosurgery literature is excessively variable and overall poor. As these papers are being published with increasing frequency, neurosurgical journals need to adopt a clear definition of a meta-analysis and insist that they be created using checklists for both reporting and methodology. Standardization will ensure high-quality publications.

Abbreviations used in this paper:AMSTAR = Assessment of Multiple Systematic Reviews; CONSORT = Consolidated Standards of Reporting Trials; JNS = Journal of Neurosurgery; MOOSE = Meta-Analysis of Observational Studies in Epidemiology; OQAQ = Overview of Quality Assesment Questionnaire; PRISMA = Preferred Reporting Items for Systematic reviews and Meta-analyses; QUORUM = Quality of Reporting of Meta-analyses.

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Contributor Notes

Address correspondence to: Paul Klimo Jr., M.D., M.P.H., 6325 Humphreys Blvd., Memphis, TN 38120. email: pklimo@semmesmurphey.com.

Please include this information when citing this paper: published online January 24, 2014; DOI: 10.3171/2013.11.JNS13195.

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