Intraoperative 5-aminolevulinic acid–induced fluorescence in primary central nervous system lymphoma

Case report

Rachel Grossman M.D., Erez Nossek M.D., Nir Shimony M.D., Michal Raz M.D., and Zvi Ram M.D.
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  • Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv University Sackler Faculty of Medicine, Tel-Aviv, Israel
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The authors report a case of primary CNS lymphoma located in the floor of the fourth ventricle that showed intense fluorescence after preoperative administration of 5-aminolevulinic acid. The authors believe that this is the first demonstration of a 5-aminolevulinic acid–induced fluorescence pattern in primary CNS lymphoma.

Abbreviations used in this paper:PCNSL = primary CNS lymphoma; UV = ultraviolet; 5-ALA = 5-aminolevulinic acid.

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Contributor Notes

Address correspondence to: Rachel Grossman, M.D., Department of Neurosurgery, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., Tel-Aviv 64239, Israel. email: rachelgr@tasmc.health.gov.il.

Please include this information when citing this paper: published online October 18, 2013; DOI: 10.3171/2013.9.JNS131076.

  • 1

    Coluccia D, , Fandino J, , Fujioka M, , Cordovi S, , Muroi C, & Landolt H: Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. Acta Neurochir (Wien) 152:17111719, 2010

    • Search Google Scholar
    • Export Citation
  • 2

    Duffner F, , Ritz R, , Freudenstein D, , Weller M, , Dietz K, & Wessels J: Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX. J Neurooncol 71:107111, 2005

    • Search Google Scholar
    • Export Citation
  • 3

    Moriuchi S, , Yamada K, , Dehara M, , Teramoto Y, , Soda T, & Imakita M, : Use of 5-aminolevulinic acid for the confirmation of deep-seated brain tumors during stereotactic biopsy. Report of 2 cases. J Neurosurg 115:278280, 2011

    • Search Google Scholar
    • Export Citation
  • 4

    Schucht P, , Beck J, , Vajtai I, & Raabe A: Paradoxical fluorescence after administration of 5-aminolevulinic acid for resection of a cerebral melanoma metastasis. Acta Neurochir (Wien) 153:14971499, 2011

    • Search Google Scholar
    • Export Citation
  • 5

    Stummer W, , Pichlmeier U, , Meinel T, , Wiestler OD, , Zanella F, & Reulen HJ: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 7:392401, 2006

    • Search Google Scholar
    • Export Citation
  • 6

    Stummer W, , Stepp H, , Möller G, , Ehrhardt A, , Leonhard M, & Reulen HJ: Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. Acta Neurochir (Wien) 140:9951000, 1998

    • Search Google Scholar
    • Export Citation
  • 7

    Stummer W, , Stocker S, , Wagner S, , Stepp H, , Fritsch C, & Goetz C, : Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery 42:518526, 1998

    • Search Google Scholar
    • Export Citation
  • 8

    Weller M, , Martus P, , Roth P, , Thiel E, & Korfel A: Surgery for primary CNS lymphoma? Challenging a paradigm. Neuro Oncol 14:14811484, 2012

    • Search Google Scholar
    • Export Citation

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