Posterior fossa calcifying pseudoneoplasm of the central nervous system

Case report

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Calcifying pseudoneoplasms of the neuraxis are rare, poorly understood masses that may arise throughout the CNS. Although these lesions are generally considered benign and noninfiltrative, reports exist that document growth of these masses on serial plain radiographs. The authors report a case of a posterior fossa calcifying pseudoneoplasm of the neuraxis demonstrating interval development of peritumoral edema on serial MRI. Their findings suggest that these lesions may sometimes behave in a more aggressive manner than commonly thought.

Abbreviations used in this paper:CAPNON = calcifying pseudoneoplasm of the neuraxis; EMA = epithelial membrane antigen.

Article Information

Address correspondence to: Kiarash Shahlaie, M.D., Ph.D., Department of Neurological Surgery, University of California Davis School of Medicine, 4860 Y Street, Suite 3740, Sacramento, California 95817. email: kiarash.shahlaie@ucdmc.ucdavis.edu.

Please include this information when citing this paper: published online February 8, 2013; DOI: 10.3171/2013.1.JNS121755.

© AANS, except where prohibited by US copyright law.

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Figures

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    Axial T2-weighted MR images of the posterior fossa obtained 38 months preoperatively (A and B), immediately preoperatively (C and D), and immediately postoperatively (E and F).

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    Computed tomography scans of the posterior fossa obtained preoperatively (A and B), immediately postoperatively (C and D), and at 4 months postoperatively (E and F).

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    Chondromyxoid matrix with palisade of pleomorphic epithelioid cells and chronic inflammatory infiltrates. H & E, original magnification ×40 (left) and ×200 (right).

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