Intraventricular hemorrhage on computed tomography and corpus callosum injury on magnetic resonance imaging in patients with isolated blunt traumatic brain injury

Clinical article

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Object

Intraventricular hemorrhage (IVH) is widely regarded as one element of a complex involving severe blunt traumatic brain injury (TBI); corpus callosum injury (CCI) is recently considered to be one factor associated with poor outcome in patients with TBI. Although postmortem studies have focused on the relationship between IVH and CCI, there have been few investigations of IVH evidenced on CT scans as a predictor of CCI evidenced on MRI.

Methods

The authors retrospectively reviewed prospectively collected data from 371 patients with blunt TBI, without trauma to the face, chest, abdomen, extremities, or pelvic girdle, requiring immediate therapeutic intervention. Their aim was to investigate whether IVH found on CT predicts CCI on MRI. Clinical and radiological data were collected between June 2003 and February 2011. First, the authors classified patients into groups of those with CCI and those without CCI, and they compared clinical and radiological findings between them. Then, they investigated prognostic factors that were related to the development of disability at 6 months after injury. The outcomes at 6 months after injury were evaluated using the Extended Glasgow Outcome Scale (GOS-E). Finally, the authors evaluated the correlation between the severity of the IVH on CT and the number of CCI lesions on MRI. The severity of the IVH was defined by the number of ventricles in which IVH was seen, and the number of CCI lesions was counted on the MRI study.

Results

On multivariate logistic regression analysis, Glasgow Coma Scale score less than 9 (OR 2.70 [95% CI 1.10–6.27]), traffic accident (OR 2.59 [95% CI 1.37–4.93]), and IVH on CT (OR 3.31 [95% CI 1.25–8.49]) were significantly related to CCI. Multivariate analysis also showed that older age (p = 0.0001), male sex (OR 3.26 [95% CI 1.46–8.08], p = 0.0065), Glasgow Coma Scale score less than 9 (OR 8.27 [95% CI 3.39–21.4], p < 0.0001), evidence of IVH on CT (OR 4.09 [95% CI 1.45–11.9], p = 0.0081), and evidence of CCI on MRI (OR 8.32 [95% CI 3.89–18.8], p < 0.0001) were associated with future development of disability (GOS-E score ≤6). Furthermore, simple regression analysis revealed the existence of a strong correlation between the severity of IVH and the number of CCI lesions (r = 0.0668, p = 0.0022).

Conclusions

The authors' results suggest that evidence of IVH on CT may indicate CCI, which can lead to disability in patients with isolated blunt TBI.

Abbreviations used in this paper:AIS = Abbreviated Injury Scale; CCI = corpus callosum injury; DAI = diffuse axonal injury; GOS-E = Extended Glasgow Outcome Scale; GCS = Glasgow Coma Scale; IVH = intraventricular hemorrhage; SAH = subarachnoid hemorrhage; TBI = traumatic brain injury.

Article Information

Address correspondence to: Hidetoshi Matsukawa, M.D., Department of Neurosurgery, St. Luke's International Hospital, 9-1 Akashicho, Chuo-ku, Tokyo 104-8560, Japan. email: mahide@luke.or.jp.

Please include this information when citing this paper: published online June 15, 2012; DOI: 10.3171/2012.5.JNS112318.

© AANS, except where prohibited by US copyright law.

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    Simple regression analysis showing the correlation between the severity of IVH and the number of CCI lesions on MRI (r = 0.0668, p = 0.0022).

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