Low-grade gliomas in adults

A review

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  • 1 Barrow Brain Tumor Research Center, Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, Arizona; and
  • 2 Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California
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In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

Abbreviations used in this paper: CBV = cerebral blood volume; DT = diffusion tensor; EORTC = European Organization for Research and Treatment of Cancer; FET = O-(2-18F-fluoroethyl)-L-tyrosine; FLT = 3′-deoxy-3′-18F-fluorothymidine; fMR imaging = functional MR imaging; GFAP = glial fibrillary acidic protein; KPS = Karonfsky Performance Status; LGG = low-grade glioma; MGMT = O6-methylguanine-methyltransferase; mTOR = mammalian target of rapamycin; PCV = procarbazine/lomustine (CCNU)/vincristine; PDGF = platelet-derived growth factor; rCBV = relative CBV; RTOG = Radiation Therapy Oncology Group; UCSF = University of California at San Francisco.

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Contributor Notes

Address correspondence to: Mitchel S. Berger, M.D., Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M779, Box 0112, San Francisco, California 94143. email: bergerm@neurosurg.ucsf.edu.

Please include this information when citing this paper: published online August 19, 2011; DOI: 10.3171/2011.7.JNS101238.

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