Perineural extension of cutaneous desmoplastic melanoma mimicking an intracranial malignant peripheral nerve sheath tumor

Case report

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The authors present a case illustrating the importance of obtaining a biopsy of any facial skin lesions in a patient presenting with an intracranial tumor involving the facial or trigeminal nerve. Conventional malignant melanoma metastasizes to the brain frequently and does not usually pose diagnostic difficulties. Direct intracranial spread of cutaneous melanoma is rare. In our patient, desmoplastic melanoma with perineural spread to the Meckel cave mimicked a malignant peripheral nerve sheath tumor clinically, radiographically, and histologically.

Abbreviations used in this paper: AP = anteroposterior; EMA = epithelial membrane antigen; MPNST = malignant peripheral nerve sheath tumor.
Article Information

Contributor Notes

Address correspondence to: Samuel L. Barnett, M.D., Department of Neurological Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8855. email: Sam.Barnett@utsouthwestern.edu.Please include this information when citing this paper: published online May 6, 2011; DOI: 10.3171/2011.4.JNS10913.
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