Pitfalls in the publication of scientific literature: a road map to manage conflict of interest and other ethical challenges

Clinical article

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The process of publishing scientific research can be hampered by potential pitfalls for journals and researchers alike; the definition and determination of authorship, legal documentation, data accuracy, and disclosure of financial conflicts of interest are all examples. In the current article, the authors discuss the challenges related to scientific medical writing and provide updated recommendations for both the prevention and management of these issues.

Abbreviation used in this paper: COI = conflict of interest.

Article Information

Address correspondence to: Alpesh A. Patel, M.D., Department of Orthopaedic Surgery, University of Utah, 590 Wakara Way, Salt Lake City, Utah 84108. email: alpesh.patel@hsc.utah.edu.

Please include this information when citing this paper: published online September 17, 2010; DOI: 10.3171/2010.8.JNS091834.

© AANS, except where prohibited by US copyright law.

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References

  • 1

    Als-Nielsen BChen WGluud CKjaergard LL: Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events?. JAMA 290:9219282003

    • Search Google Scholar
    • Export Citation
  • 2

    Bekelman JELi YGross CP: Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 289:4544652003

    • Search Google Scholar
    • Export Citation
  • 3

    Bhandari MBusse JWJackowski DMontori VMSchünemann HSprague S: Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. CMAJ 170:4774802004

    • Search Google Scholar
    • Export Citation
  • 4

    Blumenthal DCampbell EGAnderson MSCausino NLouis KS: Withholding research results in academic life science. Evidence from a national survey of faculty. JAMA 277:122412281997

    • Search Google Scholar
    • Export Citation
  • 5

    Brown AKraft DSchmitz SMSharpless VMartin CShah R: Association of industry sponsorship to published outcomes in gastrointestinal clinical research. Clin Gastroenterol Hepatol 4:144514512006

    • Search Google Scholar
    • Export Citation
  • 6

    Cooper RJGupta MWilkes MSHoffman JR: Conflict of interest disclosure policies and practices in peer-reviewed biomedical journals. J Gen Intern Med 21:124812522006

    • Search Google Scholar
    • Export Citation
  • 7

    Davidson RA: Source of funding and outcome of clinical trials. J Gen Intern Med 1:1551581986

  • 8

    Finucane TEBoult CE: Association of funding and findings of pharmaceutical research at a meeting of a medical professional society. Am J Med 117:8428452004

    • Search Google Scholar
    • Export Citation
  • 9

    Friedberg MSaffran BStinson TJNelson WBennett CL: Evaluation of conflict of interest in economic analyses of new drugs used in oncology. JAMA 282:145314571999

    • Search Google Scholar
    • Export Citation
  • 10

    Heckman JD: Retractions. J Bone Joint Surg Am 91:9652009. (Retractions in J Bone Joint Surg Am 87: 536–542 2005; J Bone Joint Surg Am 89: 1343–1358)

    • Search Google Scholar
    • Export Citation
  • 11

    Khan SNMermer MJMyers ESandhu HS: The roles of funding source, clinical trial outcome, and quality of reporting in orthopedic surgery literature. Am J Orthop 37:E205E2122008

    • Search Google Scholar
    • Export Citation
  • 12

    Krimsky SRothenberg LS: Financial interest and its disclosure in scientific publications. JAMA 280:2252261998

  • 13

    Kuklo TRGroth ATAnderson RCFrisch HMIslinger RB: Recombinant human bone morphogenetic protein-2 for grade III open segmental tibial fractures from combat injuries in Iraq. J Bone Joint Surg Br 90:106810722008. (Retraction in J Bone Joint Surg Br 91: 285–286 2009)

    • Search Google Scholar
    • Export Citation
  • 14

    Lynch JRCunningham MRWarme WJSchaad DCWolf FMLeopold SS: Commercially funded and United States-based research is more likely to be published; good-quality studies with negative outcomes are not. J Bone Joint Surg Am 89:101010182007

    • Search Google Scholar
    • Export Citation
  • 15

    Nathan DGWeatherall DJ: Academic freedom in clinical research. N Engl J Med 347:136813712002

  • 16

    Perlis RHPerlis CSWu YHwang CJoseph MNierenberg AA: Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry. Am J Psychiatry 162:195719602005

    • Search Google Scholar
    • Export Citation
  • 17

    Reuben SSEkman EF: The effect of cyclooxygenase-2 inhibition on analgesia and spinal fusion. J Bone Joint Surg Am 87:5365422005. (Retraction in J Bone Joint Surg Am 91: 965 2009)

    • Search Google Scholar
    • Export Citation
  • 18

    Robinson RGJorge REMoser DJAcion LSolodkin ASmall SL: Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA 299:239124002008

    • Search Google Scholar
    • Export Citation
  • 19

    Rochon PAGurwitz JHSimms RWFortin PRFelson DTMinaker KL: A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis. Arch Intern Med 154:1571631994

    • Search Google Scholar
    • Export Citation
  • 20

    Rowan-Legg AWeijer CGao JFernandez C: A comparison of journal instructions regarding institutional review board approval and conflict-of-interest disclosure between 1995 and 2005. J Med Ethics 35:74782009

    • Search Google Scholar
    • Export Citation
  • 21

    Scott J: Withdrawal of a paper. J Bone Joint Surg Br 91:2852862009

  • 22

    Shah RVAlbert TJBruegel-Sanchez VVaccaro ARHilibrand ASGrauer JN: Industry support and correlation to study outcome for papers published in Spine. Spine 30:109911052005

    • Search Google Scholar
    • Export Citation
  • 23

    Singer N: Medical papers by ghostwriters pushed therapy. New York Times August42009. (http://www.nytimes.com/2009/08/05/health/research/05ghost.html?ref=wyeth) [Accessed August 24 2010]

    • Search Google Scholar
    • Export Citation
  • 24

    Vogel G: Publishing sensitive data: who calls the shots? Long-suppressed study finally sees light of day. Science 276:5255261997

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