Neuritis ossificans of a cranial nerve

Case report

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The authors report the case of intracranial neuritis ossificans presenting as chronic accessory neuropathy. Neuritis ossificans is a rare reactive nerve disease that has been reported to affect systemic peripheral nerves. To the best of the authors' knowledge, this is the first documented case of neuritis ossificans observed in a cranial nerve. The lesion was revealed on imaging studies and appeared, intraoperatively, as a nonsessile intradural lesion with significant calcification of rootlets of the lower cranial nerves. Microscopically, the lesion featured zonal heterotopic calcification typical of neuritis ossificans. Although it is a rare entity, neuritis ossificans can be considered in the differential diagnosis of lower cranial nerve neuropathy.

Article Information

Address correspondence to: Craig M. Kemper, M.D., 801 35th Street, Suite 400, Austin, Texas 78705. email: cmkmd@austin.rr.com.

Please include this information when citing this paper: published online May 28, 2010; DOI: 10.3171/2010.5.091931.

© AANS, except where prohibited by US copyright law.

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Figures

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    Axial CT scan demonstrating an area of homogeneous concentric hyperdensity at the hypoglossal foramen.

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    Axial T2-weighted MR image demonstrating an area of hypointensity in colocalizing to the lesion observed on the CT scan consistent with the presence of calcification at the hypoglossal foramen.

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    Photomicrograph of the lesion showing a central area of dense calcification surrounded by an inflammatory infiltrate among nerve fibers. H & E, original magnification × 400.

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