Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage

Case report

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  • 1 Departments of Neurological Surgery and
  • | 2 Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults. The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis. To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease). This is the second report of primary intracranial AFH. Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions. In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH. Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern. The diagnosis was confirmed using immunohistochemical and molecular studies.

Abbreviations used in this paper:

AFH = angiomatoid fibrous histiocytoma; FISH = fluorescence in situ hybridization.

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  • 1

    Antonescu CR, , Dal Cin P, , Nafa K, , Teot LA, , Surti U, & Fletcher CD, et al.: EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 46:10511060, 2007

    • Search Google Scholar
    • Export Citation
  • 2

    Antonescu CR, , Nafa K, , Segal NH, , Dal Cin P, & Ladanyi M: EWS-CREB1: a recurrent variant fusion in clear cell sarcoma–association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 12:53565362, 2006

    • Search Google Scholar
    • Export Citation
  • 3

    Costa MJ, & Weiss SW: Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol 14:11261132, 1990

    • Search Google Scholar
    • Export Citation
  • 4

    Dunham C, , Hussong J, , Seiff M, , Pfeifer J, & Perry A: Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes. Am J Surg Pathol 32:478484, 2008

    • Search Google Scholar
    • Export Citation
  • 5

    Enzinger FM: Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer 44:21472157, 1979

    • Search Google Scholar
    • Export Citation
  • 6

    Fanburg-Smith JC, & Miettinen M: Angiomatoid “malignant” fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol 30:13361343, 1999

    • Search Google Scholar
    • Export Citation
  • 7

    Hallor KH, , Micci F, , Meis-Kindblom JM, , Kindblom LG, , Bacchini P, & Mandahl N, et al.: Fusion genes in angiomatoid fibrous histiocytoma. Cancer Lett 251:158163, 2007

    • Search Google Scholar
    • Export Citation
  • 8

    Pratibha R, & Ahmed S: Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. Int J Paediatr Dent 16:363369, 2006

    • Search Google Scholar
    • Export Citation
  • 9

    Thway K: Angiomatoid fibrous histiocytoma: a review with recent genetic findings. Arch Pathol Lab Med 132:273277, 2008

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