Cigarette smoking as a risk factor for recurrence of aneurysms treated by endosaccular occlusion

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  • 1 Department of Endovascular Surgery, Roosevelt Hospital, New York, New York
  • 2 Department of Epidemiology and Biostatistics, School of Public Health, Drexel University; and
  • 3 Department of Neurosurgery and Neuroendovascular Surgery, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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Object

Aneurysms treated by endovascular coil embolization have been associated with coil compaction, and the rate of recanalization has been reported to be as high as 40%. The authors report the first published evidence of a correlation between aneurysm recanalization correlated with a history of cigarette smoking.

Methods

The authors conducted a retrospective chart review of all cases involving patients admitted to their institution from January 1, 2003, to December 31, 2003, for treatment of a cerebral aneurysm. Cases in which patients were treated with coil embolization were reviewed for inclusion. Coil compaction was defined as change in the shape of the coil mass. Aneurysm recanalization was defined as an increase in inflow to the aneurysm in comparison with baseline. The incidence of coil compaction and the relationship with cigarette smoking history were compared in patients with and without recurrence.

Results

A total of 110 patients qualified for inclusion. The odds ratio (OR) for aneurysm recanalization after endosaccular occlusion with respect to history of cigarette smoking was significant for the entire cohort (OR 4.53, 95% confidence interval [CI] 1.95–10.52) and especially for the female cohort (OR 3.72, 95% CI 1.45–9.54). The male cohort demonstrated a trend toward a direct correlation, but the sample size was not large enough for statistical significance (OR 7.50, 95% CI 1.02–55.00).

Conclusions

There was an increased risk of recanalization especially in patients with low-grade subarachnoid hemorrhage who had a history of cigarette smoking. These data suggest a correlation between cigarette smoking and aneurysm recurrence.

Abbreviations used in this paper: CI = confidence interval; ISAT = International Subarachnoid Aneurysm Trial; OR = odds ratio; SAH = subarachnoid hemorrhage.

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Contributor Notes

Address correspondence to: Erol Veznedaroglu, M.D., Department of Neurosurgery, 909 Walnut Street, Philadelphia, Pennsylvania 19107. email: Erol.Veznedaroglu@Jefferson.edu.
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